Yes super familiar with those diagnoses (I’m and EM and Family Physician in addition to Anti-Aging/Regen). The vast majority of folks with medial or lateral epicondylitis (the only difference between the two diagnosis is the side of the elbow affected) are not golf or tennis players. However, if Boron works for arthritis, I’d not be surprised if it works for this. I’ve however not investigated Boron in this setting - but it would make sense.
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I tried everything for tennis elbow including prp injections. This massage gun protocol worked in about 5 minutes. It was amazing:
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Results:
Impact of long-term rapamycin treatment on age-related osteoarthritis in common marmoset
Results: Rapamycin decreased P-RPS6 Ser235/36 and increased P-Akt2 Ser473 in cartilage, meniscus, and infrapatellar fat pad, suggesting inhibition of mTORC1 but not mTORC2 signaling. Rapamycin-treated marmosets had lower lateral synovium score versus control but there was no difference in the age-related increase in microCT or cartilage OA scores. Subchondral bone thickness and thickness variability were not different with age but were lower in rapamycin-treated geriatric marmosets, which was largely driven by females. Rapamycin also tended to worsen age-related meniscus calcification in female marmosets. Conclusion: Oral rapamycin attenuated mTORC1 signaling and may have caused feedback activation of mTORC2 signaling in joint tissues. Despite modifying site-specific aspects of synovitis, rapamycin did not modify the age-associated increase in OA in geriatric marmosets. Conversely, rapamycin may have had deleterious effects on meniscus calcification and lateral tibia subchondral bone, primarily in geriatric female marmosets.
Dennis M Minton, Aditya R Ailiani, Michael D.K. Focht, Mariana E Kersh, Angela J Marolf, Kelly S Santangelo, Adam B Salmon and Adam R Konopka
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I tend to think that tests of rapamycin beyond holding down the immune response should be cycled. Even in small creatures. The half life in mice has been reported to be 15h. Hence daily dosing is essentially continual.
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I’m on week 8 of Rapamycin (the past 3 weeks at 5mg/wk) and unfortunately have been noticing arthritic symptoms in several fingers and joint pain in my knees. Prior to Rapamycin, the pain in all was very mild and transient but now my fingers are swollen and stiff 24/7, especially my right index finger (in the absence of trauma).
I’ve also been noticing swollen lymph nodes in my neck, right near my trachea and thyroid.
All of these symptoms have been gradually getting worse since I started Rapamycin so I’m going to pause on it for 6-8 weeks and observe the results. I’m really hoping everything calms down/gets better.
Definitely feeling discouraged and down because I really wanted this to work for me. Perhaps down the road I can try again but at a smaller dose per week, ie 1-3mg.
Saw this article talking about a study that suggested Rapamycin made OA worse in test subjects. 
- Brian (39 y/o)
P.S. I had pre-existing conditions so perhaps this is why Rapamycin just isn’t good for me? I struggled with chronic pain (Fibromyalgia) and possibly have CAEBV (Chronic Activated EBV) but that’s yet to be diagnosed although blood tests are pointing to it. Maybe the 5mg was just too high for me and was having an unwanted immunosuppressant response on my body. I was going Rapamycin would help me with all these pre-existing conditions but, alas…
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Sorry to hear you’re having trouble. We need to read the research paper described in the press release you shared to understand the finding, if it was in fact eventually published. Please share a link if you have one.
The few experimental studies I’ve seen show some improvement in osteoarthritis (see Intra‐articular injection of rapamycin microparticles prevent senescence and effectively treat osteoarthritis and Rapamycin protects chondrocytes against IL-18-induced apoptosis and ameliorates rat osteoarthritis).
Maybe you’ll do better a low dose.
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Yes, Brian… you’re under forty years of age, that’s a huge dose.
My son’s 33 years old and he only takes 2mg every week. Benefits weight loss 25 pounds… now stable and… neurological throat issues now gone.
I think your plan… take a break… start low. A little can go far… your body is still prime.
Even for me… reduced to 4 mg… high was messing with inflammation. Sounds like you too… swelling and arthritis.
Let us know how the rest goes.
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Thank you so much for the encouragement and the background on you and your son’s experience. This was really helpful and I really appreciate it. Definitely feeling a bit of hope again. 
I’ll take a 4 to 6-week break and then start back up again but max out at 2 mg per week and see how that feels for a couple months.
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Yes here is my GlycanAge results past 3 years.
On my first test, I’d already been taking rapamycin for about a year, 6 mg. No grapefruit juice… dosing once a week. It lowered the inflammation in my body biologically to that of 37 year old person.
Some researchers (Mikhail Blagosklonny) were saying more is better. So I up my 6 mg to 8 mg with Grapefruit juice. My rapamycin blood load was 53 to 56 ng/mL i did this for a period of seven months. My inflammation rose ond I biologically aged 14 years to 51 biological age. Ouch!!
So just as much as rapamycin can decrease your inflammation (swelling and pain). All the way back to that of a thirty seven years old, it can increase your inflammation too. Mine shot up to 51 years. See chart below for the spike.
Currently, my GlyanAge is 44 - 42 biological age, which means I’m back to almost where I was several years ago. Plus a few years for chronological age.
I hope this demonstration of rapamycin in small dose decreasing inflammation, and too much increasing inflammation…shows you the importance of your dose. Too low nothing… too high poison… you are looking for the middle ground… just right.
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Interesting, my experience is the opposite of yours. My PsA has actually diminished. I try to take enough rapamycin to get over 10ng/L after 24 hour blood test. My left middle finger is completely healed and my right middle finger is nearly painless. My finger nails are completely looking better than before. I’m sure some improvements are still possible but the pitted appearance has gone. I also take a daily dose of vitamin d of 7000iu.
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