Prostatitis, Antibiotics, and Rapamycin

Thank you both Neo and Dr. Fraser. I will hold the Farxiga for now.


My experience from decades of painful prostate pain is that prostatitis is a symptomatic, complex condition that, in quite a few cases, is not very well understood. I like to share some of my experiences. The best way for me has been to manage my painful prostate through a trial-and-error approach.

  • If you have a bacterial infection, then you might be treated with the proper antibiotics. But then again, you might be prone to reoccurring bacterial infections or non-bacterial prostatitis.

Even if there is no sign of a bacterial infection, you might try antibiotics anyway. In my special case, I always got a short time of complete relate from doxycycline. Then, after a week or so, the discomfort grew back again. This is not a strange observation, not now that I have learned that doxycycline has other effects than just being an antibacterial agent. It comes with anti-inflammatory actions, and together with azithromycin and vitamin C, it might act on stem cells.

Since my symptoms have gotten much less irritating, I don’t treat them with antibiotics anymore. But when I did, I got the best effect from Sulfametoxazol 400mg + 80 mg trimetoprim mornings and evenings for three weeks and then once a day for another 4–5 weeks.

I have also had relief from pumpkin seed oil and Viagra.

Another intriguing personal observation is that, when I do a senolytic protocol with fisetin 30 mg/kg body weight, mixed with oil and black pepper, I get restored prostate function and short period of complete relief from any symptoms that I still might have.

In my case, a non-bacterial, painful prostate is still a mysterious condition that requires a lot of patience and a trial-and-error approach.


One last thing on this - with any bacterial infection – it is critical to tightly manage blood glucose into as close to a normal range as possible. Letting it run high makes it very difficult to the antibiotics to overwhelm the bacteria who enjoy feasting on glucose. I find treatment failures go way up when patients have hyperglycemia - or worse yet obesity (without weight adjust antibiotic dosing - which few physicians and pharmacists seem to address) and hyperglycemia.


Interesting insights – and yes, just like women with interstitial cystitis - often times it isn’t infection - sometimes antibiotics help, but other treatments often are the key. The anti-inflammatory effects of macrolide or tetracycline antibiotics may be the active ingredient, not the antibiotic effect. There is a lot we don’t know and patient’s individual experiences on what works for them is an area for learning.


I think we want to be sure the other direction though, and until we are we should be careful - and @lsutiger might want to especially be so right now

Btw, here is one of the threads where it had been discussed elsewhere

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This case clearly illustrates why medical providers typically don’t make “curbside consultations”. You need to have patient’s whole medication information - HPI, past medical history, med lists, physical exam, potential tests before make any recommendations.


@lsutiger I would advise you to discuss all of this with your Urologist, rather than assuming a group of strangers on the internet are correct. And I don’t mean that as an insult to anyone trying to help here.

Unfortunately, even on this forum, there are some individuals at the far extremes of the bell curve.


KarlT, indeed, I will be discussing all of this with my urologist. The info shared on my post, however, has helped provide me with the information to have a better conversation with my urologist. Thank you all for your input.