Proline restores mitochondrial function and reverses aging hallmarks in senescent cells

#61

i’ve seen you post at longecity. Why don’t you ask Turnbukle for the reference? You can also post that question/request at linkedin (Am not a member).

The article below contains the following statements:

Both mitochondrial fission and fusion seem to be required to maintain mitochondrial function. However, the mechanisms differ. Fission occurs probably to protect function by facilitating equal segregation of mitochondria into daughter cells during cell division and to improve distribution of mitochondria along microtubules tracks. In addition, fission may also help to isolate segments of damaged mitochondria, promoting their clearance by macroautophagy as discussed below [[36](Mitochondrial Fusion/Fission, Transport and Autophagy in Parkinson's Disease: When Mitochondria Get Nasty - PMC)]. Besides to maintain normal mitochondrial functions, mitochondrial fusion, as well as mitochondrial fission have also been associated with cell death/survival mechanisms [37, 38

#62

I am not that focussed on this point. You are welcome to ask yourself.

#63

Okay. I mistakenly thought you were asking me.

#64

Thank you for your reply Juan :slight_smile: Intuitively, I also feel that my crash might point to somewhat dysfunctional mitochondria. I’ll be patient, try some more and see what happens.

#65

Has John or anybody else carried out a high-dose proline trial by now? Belatedly I am thinking about using my big supply of proline.

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#66

I took 18 gtams of proline daily for 14 days.

Alas, I was not able to get any mitochondrial biopsy test. A VO2 max test is a very imperfect marker for mitochondrial health since there are other crucial factors in play and the absence of any effect is no proof whatsoever of proline not strengthening mitochondria. I did the test anyway, my VO2 max was up 3 % compared to 18 months ago.

I noticed nothing subjectively, neither positive or negative.

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