I tend to think of low dose as resulting in 0.05mM serum levels or lower. Sadly below the minimum threshold of my lab.
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Diet Quality and Dementia Risk in Older Adults With Alzheimer Pathology
Pop-sci article:
Anti-inflammatory diets may lower dementia risk, even in those with early signs
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Higher blood glucose levels linked to faster brain aging
Faster brain aging has been linked to various neurological and psychiatric disorders, as well as some neurodegenerative diseases. The factors that influence the speed at which the brain ages, however, have not yet been clearly and comprehensively elucidated.
Researchers at Jilin University and China Medical University recently analyzed available neuroimaging, genomic and biological data to better understand the contribution of metabolic processes (i.e., the chemical reactions that transform food into energy) to brain aging. Their findings, published in Molecular Psychiatry, suggest that higher levels of glucose in the blood are associated with accelerated brain aging.
Uncovering metabolic signatures of brain aging with AI
To explore the biological underpinnings of brain aging, the researchers analyzed data from the UK Biobank, a large biomedical database that contains health-related, genetic and imaging data collected from thousands of people living in the U.K. By analyzing these people’s brain scans, they derived measurable brain features, such as the size of specific brain regions, tissue characteristics and structural changes.
Subsequently, they trained machine learning algorithms to predict the age of people based on the brain features they identified. They found that a specific statistical method, known as a least absolute shrinkage and selection operator (LASSO) regression model, was best at predicting the age of people’s brains, with an average error rate of 3.26 years.
https://medicalxpress.com/news/2026-07-higher-blood-glucose-linked-faster.html
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Diabetes (SGLT2) drug tied to lower dementia risk
Unexpected benefit: SGLT2 inhibitors, used for diabetes, were linked to reduced dementia risk in psychiatric patients.
High-risk focus: Older adults with mood or psychotic disorders face higher dementia rates, but few prevention options.
Future implications: Researchers call for more trials to confirm benefits and explore metabolic-brain health connections.
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