I tend to think of low dose as resulting in 0.05mM serum levels or lower. Sadly below the minimum threshold of my lab.
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Diet Quality and Dementia Risk in Older Adults With Alzheimer Pathology
Pop-sci article:
Anti-inflammatory diets may lower dementia risk, even in those with early signs
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Higher blood glucose levels linked to faster brain aging
Faster brain aging has been linked to various neurological and psychiatric disorders, as well as some neurodegenerative diseases. The factors that influence the speed at which the brain ages, however, have not yet been clearly and comprehensively elucidated.
Researchers at Jilin University and China Medical University recently analyzed available neuroimaging, genomic and biological data to better understand the contribution of metabolic processes (i.e., the chemical reactions that transform food into energy) to brain aging. Their findings, published in Molecular Psychiatry, suggest that higher levels of glucose in the blood are associated with accelerated brain aging.
Uncovering metabolic signatures of brain aging with AI
To explore the biological underpinnings of brain aging, the researchers analyzed data from the UK Biobank, a large biomedical database that contains health-related, genetic and imaging data collected from thousands of people living in the U.K. By analyzing these people’s brain scans, they derived measurable brain features, such as the size of specific brain regions, tissue characteristics and structural changes.
Subsequently, they trained machine learning algorithms to predict the age of people based on the brain features they identified. They found that a specific statistical method, known as a least absolute shrinkage and selection operator (LASSO) regression model, was best at predicting the age of people’s brains, with an average error rate of 3.26 years.
https://medicalxpress.com/news/2026-07-higher-blood-glucose-linked-faster.html
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Diabetes (SGLT2) drug tied to lower dementia risk
Unexpected benefit: SGLT2 inhibitors, used for diabetes, were linked to reduced dementia risk in psychiatric patients.
High-risk focus: Older adults with mood or psychotic disorders face higher dementia rates, but few prevention options.
Future implications: Researchers call for more trials to confirm benefits and explore metabolic-brain health connections.
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How dementia is being defeated
Incidence among the elderly is falling fast
Mr Stallard has been working for a decade to corroborate this revelation. His findings have, if anything, become even more striking. Last year he and some colleagues published research in the Journal of the American Medical Association showing that, whereas 40 years ago three in every ten Americans aged 85-89 had dementia, by 2024 just one in ten had it (see chart 1). What is more, America is not the only beneficiary of this trend. Between 1988 and 2015 the share of older people being diagnosed with dementia fell by 13% a decade across six countries in North America and Europe, according to a study of almost 50,000 people by Frank Wolters of the Erasmus Medical Centre in Rotterdam, and colleagues.
chart: the economist
Some smaller studies have also found big declines. Data from the Framingham Heart Study, which has tracked three generations in an American town, show an average drop in new dementia cases of 20% per decade over almost 40 years between the late 1970s and early 2010s. Those who were entering their dotage when Daft Punk’s “Get Lucky” was topping the charts (2013) were 44% less likely to have dementia than those who were doing so when Sting was urging Roxanne to switch off her red light (1978).
Whereas most earlier studies had simply pooled elderly people and then applied a statistical adjustment for age, Mr Stallard looked at narrow bands of ages to compare different cohorts of people over 50 years. By examining the changes between each successive cohort, he calculates that dementia rates have been declining by 2.5-3% for each calendar-year cohort. “In my view it was the Copernican revolution in the field,” he says, turning assumptions about dementia’s spread upside down. Similar cohort studies in various European countries and Japan have found comparable trends there, too.
Full story: How dementia is being defeated (The Economist)
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An anti-inflammatory diet may prevent dementia, even in people at higher risk, new study suggests
About the latest research
The new study, published in June in JAMA Network Open, sought to determine whether healthy eating patterns could modify dementia risk in older adults with blood biomarkers indicating Alzheimer’s-related brain changes or other signs of brain cell damage.
To do so, the researchers analyzed data from adults without dementia, ages 60 and older, who took part in the Swedish National Study on Aging and Care. A total of 1,865 participants, with an average age of 70, were followed for up to 15 years.
At the start of the study, researchers measured three blood biomarkers linked to Alzheimer’s disease and other signs of damage or stress in the brain. They also assessed participants’ diets, lifestyle habits and health status, updating this information at follow-up visits three and six years later.
Participants’ diet information was used to assess adherence to three dietary patterns: a Mediterranean-style diet, the Alternative Healthy Eating Index and the Reverse Empirical Dietary Inflammatory Index, which measures the inflammatory potential of a person’s diet (a higher score denotes a more anti-inflammatory diet). Higher adherence scores for each dietary pattern indicate a higher quality diet.
Each diet pattern highlights different aspects of diet quality, and they all emphasize vegetables, fruits, nuts and whole grains while limiting more inflammatory foods such as red and processed meats and sugary drinks.
Better diets, especially less inflammatory ones, tied to lower dementia risk
Across all participants, healthier diet patterns were associated with a lower likelihood of developing dementia.
When the researchers analyzed participants according to their levels of blood biomarkers, however, they found striking results.
Greater adherence to all three diet patterns was generally associated with a lower risk of dementia among people with lower levels of blood biomarkers.
Full article: An anti-inflammatory diet may prevent dementia, even in people at higher risk, new study suggests
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Apparently:
Inhaling high-dose CO2 clears Alzheimer’s proteins from the brain
Intermittently inhaling a high dose of carbon dioxide seems to remove the proteins amyloid and tau, which are implicated in Alzheimer’s disease, from the brain by boosting its glymphatic system.
If it doesn’t kill you first.
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For mind and body: Community gathering places may counteract cognitive disability
Effect Modification by Exercise Habit on the Association Between Participation in Community Gathering Places and Cognitive Disability
https://agsjournals.onlinelibrary.wiley.com/doi/10.1111/jgs.70499
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