Since MR which is basically genetic studies are one of the best tools in medicine for predicting disease and finding drugs (drugs which have genetic support have higher likelihood of succeeding), could slow progress in Alzheimer’s Disease and dementia be because of genetic research underpinning cognitive decline with age being controversial?
Recently, claims of improved prediction of cognitive ability: predictor correlation of ~ 0.4 or 0.5 with actual IQ scores. I wrote ~15 years ago that we would surpass this level of prediction, given enough data. I have maintained for a long time that complex trait prediction is largely data-limited. Progress has been slow as there is almost zero funding to accumulate cognitive scores in large biobanks. This is because of persistent ideological attacks against this area of research.
Almost all researchers in genomics recognize human cognitive ability as an important phenotype. For example, cognitive decline with age should be studied carefully at a genetic level, which requires creation of these datasets. However most researchers are AFRAID to voice this in public because they will be attacked by leftists.
I note that as the Overton window opens some cowardly researchers who were critical of GP [genomic prediction] in its early days (even for disease risk reduction!) are now supporting companies that openly advertise embryo IQ selection.
https://x.com/hsu_steve/status/1951263974747488601#m
I don’t personally care that much about IQ/intelligence, health seem like most important especially in the age of AI, I don’t think anyone believes their kids or grandkids will be smarter than AI. But controversy surrounding genetic research for cognitive abilities might slow down some forms of research that can help with cognitive aging.
Genetics is the most important area of medicine for sure, except randomized trials of course.
