Risk mitigation begins at birth (or before birth with preimplantation genetic testing). We can model healthy diet and exercise for our children and encourage them to participate in sports that are relatively safer such as swimming or golf rather than more dangerous ones such as boxing or base jumping.
Eventually gene editing may provide one of the best ways to dramatically reduce the risk of Alzheimer’s. Until then, maintaining a healthy lifestyle and intermittent rapamycin use (in adults) seems like a great start.
I don’t want to argue about CR. My point was just that we don’t know anything that works in “metabolically, weight and exercised optimized individuals”. So it’s not only GLP1: it’s the same for every single intervention.
The funny thing is that one and so far only reason I personally (while I’m still “optimized”) would consider a GLP med for longevity is to help me achieve a bit more calorie deficit/restriction in an easier way
A new study, published in the journal GeroScience , highlights a promising link between nut consumption and a reduced risk of dementia. The findings suggest that middle-aged and older adults who regularly consume nuts have a 12% lower chance of developing dementia compared to non-consumers. This protective effect was particularly strong for those who consumed up to a handful of unsalted nuts daily, which appeared to yield the most significant cognitive benefits.
A new international study led by a team of scientists from Ben-Gurion University of the Negev showed controlling blood sugar levels is a significant key mechanism linking diet to slower brain aging.
“By tracking the volumes of dozens of different brain regions with MRI technology, we quantified the participants’ brain volumes before and after dietary intervention,” Shai added.
The original experiment, published about two years ago, demonstrated a 50% reduction in brain atrophy while consuming a green Mediterranean diet, which included the consumption of Mankai and green tea.
Now, the current study’s findings highlight blood sugar control as the primary link between diet and the brain regions vital for cognitive function (like the hippocampus, lateral ventricles, thalamus and cerebellum), motor control and sensory processing.
“These findings are crucial not only for people with high blood sugar but for everyone’s health at any age,” Shai explained. “We know that diabetics have a significantly higher risk of dementia, which isn’t a new finding. High blood sugar levels place strain on brain cells and lead to long-term damage, impairing brain function.”
“In this process, advanced glycation end-products (AGEs) form as sugars bind to cellular proteins like collagen and blood vessels, which reduces vascular elasticity and weakens blood supply to the brain.”