What PEARL concluded was that if you don’t take much Rapamycin not much happens.
I quite like Physionic and have listened to this. He has noticed the absence of enteric coating. He said the researchers “Nerfed the trial”. That is an accurate statement.
Hence his title is pure clickbait.
My own experiment I am doing at the moment is costing me about GBP 300 per week in terms of testing, but is actually getting some clear results (on an n=1 no placebo basis).
The high testing cost will last about 4-5 weeks and then my testing costs will go back to normal.
I agree with you about Nicolas using clickbait. I am following him and his YT channel (thinking of becoming an Insider soon) since the begining but lately, IMHO, he is abusing this kind of headlines for a well reputed site like his. In the video on sodium chloride (salt) - Heart attack risk - he admitted “social media rewards engagement and supresses work where people leave early which disincentivizes creators”. Well, we all know its a tight rope to walk for youtubers.
We will not see much until very long-term studies are done.
Do we really know what to measure in the short term? Such things as CRP are all over the place. Only long-term studies that show absolute survival rates are meaningful. Short-term studies, and yes, 48 weeks is a short-term study unless the participants are followed for many years to come.
FWIW: You can buy enteric-coated capsules from Amazon and put your rapamycin pills in them before taking them with GFJ. This is what I do. I do not use olive oil, fatty meals, etc. because I, from the interpretation of my current reading, want a spike and do not want to increase the AUC.
Based on all his research, what are the top 3 longevity interventions outside of the core common sense ones - exercise, diet, sleep, not smoking, right weight, etc…
What does he do personally? (On or off the record).
Attia speaks a lot about Zone 2 exercise to improving mitochondrial function, does this happen systematically or is it just in the muscles exercised? Which areas of the body has an improvement in function or density of mitochondria because of Zone 2? Might organs have these improvements? Is there any way for the body to transport mitochondria elsewhere? Might Zone 2 improve density/function of mitochondria in i.e the brain directly from exercise or even transport?
