The website is interesting; However, I went to the ‘experts’ page and clicked on Dr. Sandra Kauffman. I’ve read her 2 monographies on longevity supplements plus I’ve been listening to several hours of interviews with her.
She says she takes all 42 supplements listed in her books. More recently, she affirms she added various pharmaceutical drugs which in some cases she thinks are more effective than supplements (for example, I remember dasatinib).
In the website though, only five supplements are cited. I wonder what’s the criterion.
Great catch. Would you point me at some resource where she lists her updated stack? We try to update everyone’s 3-4 times / year but its somehow artisanal and far from perfect.
Also consider we restrict our list of compounds to the top 25 most used to keep it simple. But dasatanib is there so we must have just missed the update l.
Thanks!
I’ve just been listening to her being interviewed in many podcasts, the more recent one being one year ago. I don’t know if she says it in her books, but in the podcasts she’s asked by the interviewers. She basically says there are so many interesting molecules that she cannot hold herself. And lately she switched to or added some pharmaceuticals. A possibility in her case would be to list the supplements in her ‘Panacea’ scheme, which are specifically targeted for individuals > 40-50 years of age. Another example would be to list the ones which score high in more mechanisms or ‘tenets’, or simply those who score highest, seven of 'em are on top fisetin being the first one.
But I’m going to be back on this and maybe write you a PM.
Another example of perhaps necessary updating is the profile of Dr. Brad Stanfeld. He keeps repeating in his podcasts that the supplement he puts on top of the list is Creatine monohydrate. It can be argued that avoiding sarcopenia and neurodegeneration is a pro-longevity strategy.
Peter Attia, another example, is strong on lipids and blood glucose control, so he takes PCKS9 and SGLT-2 inhibitors. I’m aware that the list may become too detailed, I didn’t check all of them, besides I just don’t know all of’em…
Well with the number of supplements that some of the top longevity enthusiasts up are taking, you would expect to see some problems from taking too many supplements.
However, I look at the top longevists and I’m envious about their epigenetic ages and biomarkers. I think our bodies are adaptive enough to create synergies between the molecules we take for longevity.
Thanks Ill definitely be updating. The limitation for now is we try to keep the list short, including only the substances several people take. But Creatine, Astaxanthin and PCSK9 and SGLT2 are likely to make the list soon.
Both considerations are true for me and probably your second paragraph is the reason why there is not just one combination that works but several. We created an API that analyzes a combination of supplements and tells you things like “you are taking 3 antioxidants maybe you can simplify and pick one” or “you are not taking anything for helping your telomeres, maybe consider adding this or that”. It doesnt have a visual interface yet but will soon.
The PANACEA
The Anti Glycation Strategy
The Anti Inflammatory Strategy
Dosage
The following are recommendations for the molecular agents. Dr. Kaufmann recommends these having tried them herself, and has personally explored their quality.
JuanDaw, yes, the two volumes on supplements by Dr. Sandra Kaufmann are some of the best monographs, if not the best presently available on this topic. A large part of my stack is based on her suggestions.
She doesn’t say that taking the whole list is too many. She says she takes all of’em and more but with smaller dosages.
Meats and Full Fat Dairy are natures best Longevity Supplement and Multivitamin
Plus full carnivore/keto results in high brain utilization of ketones for fuel, and low-no carbs eliminates the need for gas producing acarbose
Omega-3 Fatty Acids (Eicosapentaenoic Acid - EPA):
Omega-3 fatty acids have been associated with anti-inflammatory effects and potential lifespan extension.
Sources in Meat: Cold-water fish such as salmon, herring, and mackerel are rich in EPA. Grass-fed meats and full-fat dairy also contain some EPA.
Astaxanthin:
Astaxanthin supplementation has shown potential in extending lifespan in NIH-funded longevity studies.
Sources in Meat: Astaxanthin is found in seafood, particularly in species like salmon, shrimp, and lobster, which accumulate it from their diet.
Coenzyme Q10 (CoQ10):
CoQ10 has been studied for its role in mitochondrial function and potential anti-aging effects.
Sources in Meat: Organ meats, such as liver and heart, are particularly rich in CoQ10.
L-Carnitine:
L-Carnitine has been investigated for its role in energy metabolism and potential to improve healthspan.
Sources in Meat: Red meats, especially beef and lamb, are high in L-Carnitine.
Creatine:
Creatine has been explored for its benefits in muscle function and potential neuroprotective effects.
Sources in Meat: Meats like beef, pork, and fish are natural sources of creatine.
Taurine:
Taurine has been studied for its antioxidant properties and potential to support cardiovascular health.
Sources in Meat: Seafood and meats, particularly dark poultry meat, contain taurine.
I believe it would be useful to include daily quantities (of meat, fish and full-fat dairy) necessary to reach the suggested daily dosages of the cited supplements.
Im just saying that if your diet is primarily meat based, the need to supplement might be lower. I take Rapa, Taurine, Creatine, TMG, finasteride (for estradiol), but since I am all meat and dairy, its probably a bit redundant in some cases.
First Inhibition of 5-alpha reductase:
-inhibiting the enzyme 5-alpha reductase, which converts testosterone into dihydrotestosterone (DHT).
-results in a decrease in DHT levels and an increase in the availability of testosterone in the body.
Then Testosterone Aromatization:
-with more circulating testosterone available, some of it is converted into estradiol via the enzyme aromatase.
