Parkinson's disease

@RapAdmin Do you have the exact minute when he mentioned PD by any chance? It’s 1h47 long, I couldn’t find by quickly skimming through it and the transcript feature doesn’t seem to work. Thanks for your help.

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At 1 hour 30 minutes.
Almost the end.

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Catching the flu increases your risk of Parkinson’s disease by 90% 14 years later. “The risk was specific for influenza, not any other infectious disease, and this increased risk showed up only a decade or more after the viral infection. Might getting vaccinated for seasonal influenza help stave off Parkinson’s? That’s an open question” Quite simply, if we can avoid infection, will we avoid neurodegeneration? This is a huge downstream benefit of @Centivax’s universal flu vaccine program — one shot to end them all.

Shingles too: “Vaccination had a pronounced protective effect on the incidence of dementia. 1 in 5 new dementia diagnoses among unvaccinated people could have been averted by vaccination. If these are truly causal effects, then getting vaccinated for shingles is far more effective, far less risky and much less expensive than anything else out there now for dementia.” — From the current issue of https://stanmed.stanford.edu/infections-link-later-life-neurodegeneration/ P.S. pregnant women who get influenza in their second trimester give birth to children who are 7x more likely to have schizophrenia in adulthood.

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Thanks a lot. So at 1:30 (rough manual transcript):

  • Matt K: “It’s an interesting concept, right? That maybe a single acute dose or a single week of dosing would have a beneficial effect on egg quality.”
  • Jon Berner: “I had a gal that came to me and we did CSF metabolomics and she had a marker for early Parkinson’s disease that was like 7 z-scores up and I think family member had Parkinson’s disease and so she got on rapa and after 3 months she said ‘Oh I don’t have anymore endometriosis it’s gone’ and she stopped rapa and never came back. Can we do a single pulse of rapa and do adverse clonal selection? It’s somewhat curative for quite a while in terms of stem cells quality. How we do that in a safe way? That’s the real challenge.”
  • Matt K: “Why is that a challenge? Are you more concerned about safety from a single acute dose than from chronic dosing?”
  • Jon B: “Do you need a pulse of 20 mg? 40 mg?”

So is there another part of the podcast where he says the PD biomarker went away @RapAdmin @Agetron?

@John_Hemming: the above seems aligned with your strategy. Have you contacted Matt K to share your experience?

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I think I have told him. He does at times respond to comments on this forum.

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No, that’s the only spot I noticed it. Reading the transcript now, it’s a little harder to understand. Do you see it as him saying that this womans’ marker for Parkinsons went away, or just the endometriosis?

I understand just the endometriosis, but then his whole point makes no sense “she had PD biomarkers [which doesn’t mean much], took rapa and then didn’t have endometriosis [which is totally unrelated]”. So :man_shrugging:

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I agree. You might try emailing him for clarification: https://www.woodinvillepsychiatric.com

Email address on this contacts page: https://www.woodinvillepsychiatric.com

Screenshot 2025-11-07 at 7.42.29 AM

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Thanks. Done. Will keep you posted.

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He’s very modern :laughing:

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Conclusion: Dr. Jon Berner is an asshole.

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I was expecting a couple of links to some literature or studies or case reports or something, it wouldn’t take much time, but maybe none exist and it’s all personal anecdote (which would make it nearly useless). Too bad.

He is pretty terrible.

He goes on a podcast and says lithium can cure dementia.
How much? He just can’t say.
How would you determine how much? He can’t say.
What testing would you do? Can’t say.

He describes his approach as if he’s an artist and there is no way to write down the method. There is no branching decision tree.

Which is a fancy, complicated way of saying he has no methods. Every patient gets whatever feels good to him that day. If they get side effects, he adjusts based on how he feels that day.

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Yes Dr. Jon Berner is at best incompetent, at worst a total scammer. It’s a disgrace for Matt Kaeberlein to have him on his podcast. It’s also not reassuring regarding Matt’s own competence.

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Matt often has odd guests, who are borderline if not total scammers: guys like de Lauer, Muntzel and several others, some gut lady, a cold plunge guy. Marginal characters or influencers with no real medical competence. He may be friends with some of them or maybe he’s looking to grow the channel so he features these influencers. I have long since complained about the quality of most of his guests, though he does have on solid guys like Brian Kennedy. Then he has guys on like Dr. Kevin White - complete puzzle, that guy never says anything, just repeats some sentence Matt says, mostly hems and haws and shifts around making faces - it’s like performance art, how long can you sit in an interview and say absolutely nothing of consequence. Then his co-host Nick - a nice guy but with zero medical knowledge, just really “guy on the street” level of understanding - maybe that’s the point, I don’t know. Oh well. There’s a distinction to be made between being a scientist and running a yt channel. Matt is not very good at the latter, but I have faith in him as a scientist.

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I noticed, reading the comments after watching one of MKs videos on YouTube, that some people were complaining that they were playing ads every 5 minutes. Makes me wonder if Optispan is making it as a health care entity, or if it’s just becoming a front for a YouTube channel… or maybe it’s the world we live in; everything gets monetized. That would at least partially explain the guest selection as a mechanism to boost subscribers and clicks. But maybe I’m being a cynic, but I’ll suspend judgement until which time as he starts promoting meat bars or some such.

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