I didn’t notice anything in the book about Acarbose or Canagliflozin
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No - its interesting, he doesn’t cover those two molecules at all.
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People are jumping on the “Outlive” bandwagon… a new cookbook that riff’s on Peter’s new book:
Outlive Diet Recipes: Over 60 Delicious and Healthy Recipes To Help You Live 10 Decades Younger in The Outlive Plan
https://www.amazon.com/Outlive-Diet-Recipes-Delicious-Healthy/dp/1959581139/
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Grifters gotta grift.
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I’m listening to the book now and am enjoying it a lot. While not much new info for the very well informed folks here, I think it will be very useful to the general public both as a good source of education and a call to action. I definitely learned more about Peter himself - see a recent episode with him on Rich Roll’s podcast for a discussion of the mental health chapter (which humanizes him a lot).
Also, I get a kick out of his speaking style, and frequent allusions to physical combat and combatants like Muhammed Ali, George Forman, and Bruce Lee while nerding out on the details of cholesterol and the like. Period. Full Stop.
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Attia does cover framework and strategy in the book. I wanted there to be a great deal more about specific tactics particularly in the areas of nutrition and “exogenous chemicals”. I think that given the very nature of this site, most people here wanted more of that information in the book. The book is very far from the complete treatment of the subject of longevity that I had hoped for.
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That’s disappointing …
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Peter Attia has recently done the podcast rounds to promote the book:
People I (Mostly) Admire
Adding Ten Healthy Years to Your Life
The Joe Rogan Experience
#1960 - Peter Attia
Rich Roll Podcast
TOOLS TO OPTIMIZE YOUR HEALTH, PREVENT DISEASE & LIVE LONGER w/ PETER ATTIA
Huberman Lab Podcast
Dr. Peter Attia: Improve Vitality, Emotional & Physical Health & Lifespan
The Tim Ferriss Show
Dr. Peter Attia — The Science and Art of Longevity (#661)
I haven’t listened to any of these yet, but the consensus of JRE Redditors is that the JRE interview is a total waste of time, with the blame being Rogan’s rather than Attia’s.
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You can apply to be his patient.
Then he will provide you with all the answers to your questions.
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There is not a single thing that Matt Kaeberlein says that I haven’t heard before, but every time I listen to one of his podcasts, I learn something new. I have Peter‘s book. I can’t wait to read it.
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The topics of anti-aging or age reversal are moving so fast, Writing a manuscript then going through the steps to publication takes a long time, maybe a couple of years. Very hard to be current with that lag time. I skipped Sinclair’s book and don’t think I missed out on anything major. Just my opinion.
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I agree, we listening and he is revealing and his use of analogies are quite interesting. About to listen to chapter 5 on rapa.
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I have reread the sections on nutrition and I believe he is actually saying a great deal. He advocating for following a few simple guidelines; (generally unprocessed food, foods that do not cause large insulin spikes, “healthy “fats, and a fairly high intake of quality proteins). He seems to be saying that if you do these things and eat only enough to not be "overnourished, you will be consuming a diet that will do all a diet can do for the promotion of longevity. Of course, we can’t know if he is correct.
It is interesting though. If Attia is correct, Bryan Johnson and Mike Lustgarten follow incredibly restrictive dietary routines for very little or no benefit. Similarly, if Attia is correct, Valter Longo’s “Longevity Diet” is vastly more restrictive for no benefit.
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I don’t think PA has ever adequately addressed the contradiction between his advocacy for methionine rich proteins (e.g. meat and whey) and literature around methionine restriction:
I do eat methionine rich foods in my ‘normal’ omnivore diet but have recently shifted more towards collagen peptides as a supplementary protein source. Not only is collagen very low in methionine, it has almost 30% glycine which, as we know offers it’s own longevity benefits:
Sure, I might be sacrificing ‘optimum’ muscle anabolism but, based on the literature above, it would seem the superior option for longevity?
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but collagen is not complete protein source and lacks L-tryptophan… as much as I know it is advisable to use it as supplement but not main protein source. I never put much thought into it as I supplement just 6g per day of collagen peptides.
edit:
Found this. Seems you can include more collagen really…
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PA makes a compelling case for lowering (minimising) both ApoB and A1C so I have seriously begun to question the prophylactic use of a drug (Rapamycin) that increases both those markers. For me Acarbose looks like a superior intervention with substantially less risk.
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That argues all the more strongly for Attia’s strategy-over-tactics approach in this book.
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That can be mitigated with a statin though, I didn’t know about A1C increasing, do you have personal experience with that?
I would rather take rapamycin+statin than no rapamycin at all, IMO. As my view is statins are very safe for the vast majority of people, they are longevity/healthspan drugs.
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Yes, I can understand the decision to take statins but I’d just rather avoid polypharmacy.
Yes A1C has been trending upwards at ~2mmol per quarter.
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