starspawn0, For me tadalafil (5 mg daily) creates a small improvement in urine flow without bad side effects and finasteride (1.25 mg daily) over many months also improves flow, but may have unwanted side effects. Both of these interventions are better than surgery, though, if they work. Finasteride will also likely reduce prostate fluid production quite a bit which may or may not be a problem for you at the young age of 53.
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It might sound impossible, but if you want to keep your prostate fluid full… a simple supplement… Sunflower Lechithin 2 capsules nightly. Buy it on Amazon. Give it 2 weeks.
Noticeable difference when I am off it.
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Does anyone know of a compounding pharmacy that will make finasteride in tiny amounts (perhaps .0625mg or .125mg)?
Cutting 1mg pills into amounts that small is difficult and grinding them into a powder is a lot of work. I have no hair concerns. I just want to help with prostate size.
Already taking 5mg cialis every other day. I haven’t found a vendor that will sell 2.5mg cialis pills either.
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Have you tried splitting an 1mg pill into 0.25mg quarters? The lowest dose finasteride works at afaik is 0.05mg per day and 0.2mg has like 80% the effect on serum DHT as 1mg.
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I haven’t started yet but may consider that.
According to my recent full bod MRI my prostate is now slightly enlarged but I am otherwise asymptomatic.
The idea for micro-dosing to minimize side effects came in part from here:
Ideally I would like to start much smaller than .25mg. Maybe I will just crush the 1mg pills and encapsulate them like the author of the above article @desmolysium
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Alternatively you can take 0.25mg every other day. DHT takes about a week after a single dose of finasteride to go back to baseline so an every other day protocol should sufficiently suppress DHT while minimizing side effects.
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Do those supplements actually reduce DHT in the blood. When i was self treating by own BPH I found them to be a waste of money. I wish I had been on Finasteride 30 years ago.
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If you take really high doses then you can expect a serum DHT reduction of about 10-20% which translates to like 5% in the prostate and hair follicles - not even remotely enough to do anything.
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ULO is very good. They are backed by the person who runs Perfecthairhealth which is a paid service looking at the science behind hair loss.
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I’d advise simply dosing less frequently. Finasteride can knock down blood levels of DHT for several days and it can knock down DHT in tissues even longer.
How about 0.5mg twice per week if you want to go low dose? Only 15%ish more than 0.125mg every day. With a good pill cutter halving a pill is far less work than quartering it or grinding etc.
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@ReppinMycin It says in your intro you take Selegeline 1.25mg 4 days a week, any reason why not everyday?
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The Hair-Loss Drug Rewriting the Rules of Masculinity. New York Times - April 7. 2026
A pill to cure baldness is changing the way men age — and how they see themselves.
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Hi there, the reason is that currently I want to limit weekly dosage to 5mg and cutting the pill into 8 is infeasible, nothing against daily dosing. I plan to up the dose to 1.25mg per day at 40-50 years old. Given the half life of the drug the EOD should be nearly as effective as every day (assuming total dosage is the same). Joseph Knoll’s recommendation of 1mg per day would work out at 7mg per week so I am only taking a 30% lower dose than the “standard”.
My general longevity strategy is to lean lightly on the levers at a younger age and then more heavily as I get older and more data emerges. Especially with drugs which are more speculative (eg. selegiline and sirolimus). I may not get the full benefit but will get some and keep the risks lower.
All of my drugs/supplements are pretty lightly dosed with finasteride 3mg per week, creatine 3g per day, lithium 1mg per day etc. Tadalafil is probably closest to a standard dose at 5mg daily. I actually need to update my bio as I have dropped sirolimus to 9mg once per fortnight and have added in telmisartan at 20mg per day.
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Surgeons can now extract individual healthy follicles from abundant areas of their patients’ heads and implant them, one by one, into the scalps’ hair deserts. Called FUE hair relocation.
If you are going to do this… expect your hair surgeon to tell you to go on daily oral finasteride and minoxidil for life. Not for the transplanted hair, those are DHT resistant (coming from back of head). It’s the hair still there that will fall out giving a weird hair pattern.
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Finasteride every other day is probably a viable strategy for men with moderately aggressive hairloss.
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I would agree based on metabolism and half life.
5 mg generally stays in one’s system 3 to 5 days. With a plasma half life of 5 to 6 hours.
Biological effects of suppressed DHT levels 14 to 30 days.
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