The observations here as well as my own experience of omega 3A supplements makes me think that there is a subpopulation that respond with mood changes when supplementing with omega 3. In this paper there is a signal in that direction.
This NHANES analysis has shown that DHA is associated with depression in American adults (OR = 0.996, 95% CI 0.993–0.999, P = 0.014). Bidirectional MR analysis demonstrated a significant causal relationship between DHA and depression in the European population (OR = 0.9, 95% CI 0.84–0.97, P = 0.006).
They say that “Three multivariate regression models were constructed: crude, unadjusted; model 1, adjusted for age, gender, and race/ethnicity; model 2, adjusted for age, gender, race/ethnicity, education, RIP, BMI, smoking, and alcohol consumption.” So obviously we want the results of model 2, but in the abstract, they only give the result of model 1 (“OR = 0.996”), whereas in the text they note “It is important to note, though, that the association between the two was not statistically significant in Model 2, but the trend remained. For this result, similar to the study by Wang et al. [22], they also observed that the association between plasma DHA and depression did not persist after controlling for all potential confounding factors.” The model 2 found OR = 0.998, 95% CI 0.995–1.001, P= 0.11) That’s not professional. It makes me doubt the rest of the paper…
They don’t cite the VITAL-DEP trial that showed increased depression with EPA + DHA but cite other small trials that align with their conclusion that DPA is protective: shows a lack of intellectual honesty
