@amuser Really great research summary on bisphosphenates! Did you take help of a GPT for this?
@John_Hemming Interesting, do you remember which paper it was?
@Steve_Combi Big thanks for sharing this! How much weight did you loss thanks to the GLP-1 Rās?
@Joseph_Lavelle: This reminds of this big human study on aspirin.
āHigher all-cause mortality was observed among apparently healthy older adults who received daily (low dose of) aspirin than among those who received placebo and was attributed primarily to cancer-related death.ā
Source: Effect of Aspirin on All-Cause Mortality in the Healthy Elderly - PubMed
55 lbās down from 195 to 140 - I varying from 140 to 143 depending on dietary choices
But Iām not concerned about weight anymore. Huge emotional weight lifted that I have endured for over 40 years. I consider GLP1-Rās to be a significant health span increasing intervention for other wise āhealthyā people who are over weight and about to become truly unhealthy as they age.
GLP1-Rās provide both emotional and physical benefits.
I donāt remember the paper, but I think it is was one of the key ones. In any event I think I have a full understanding of the mechanisms behind aging and metformin wonāt make that much difference.
Hereās my list if I had to make an educated guess
Rapamycin (overall)
SGLT2 (T2D, cardiovascular, and kidney protection)
ARB/ACE (mostly due to BP lowering effect)
Statins/PCSK2 or whatever else lowers ApoB
GLP1 (at low doses IMO for longevity)
Acarbose
PDE-5
A well dosed multivitamin. Most arenāt good.
Taurine
Astaxanthin or Creatine
If I could rank bio identical hormones as a whole to prevent age related decline, that might be first though. There are just so many of them and not all are equally important.
Also tempting to put naproxen somewhere based on the UK Biobank study that got attention last year but we need way more data.
Am I crazy here, I am starting to think the peptides are moving forward and nothing else is. They might go in there too, if we figure out how to manage them.
Ah kind of. I just want a little more evidence. I used to take sulforaphane but havenāt for a few years. Itās criminally understudied if you ask me.
Sulforaphane evidence in food is good though. Just not sure if itās translates to supplements. I think about how spermidine has good evidence in food but the supplements pretty much did nothing.
The bottom line per Nir: SGLT2 Inhibitors (12) and Metformin (11*) score highest, suggesting strong longevity potential. Rapamycin (11(9)) shows promise in lab studies but lacks human mortality data.
How could SGLT2 have the strongest data, given that it is relatively new (10 yrs or so)?
Thatās pretty good! SGLT2IS have more impact on various diseases and longevity than Grok mentions. Taurine also prevent formation of senescent cells. These are finer points, but Groks summary is better than mine.
I wouldnāt ponder this simplistic scoring too deeply. Itās just intended to quickly identify the high potential items. Itās almost entirely subjective.
Our personal experience with sulphoraphane supplementation is quite amazing. I had read that it may help with Autism so I purchased some for our, at that time 4y/o autistic grandson. He is now 5.
He was non-verbal, no eye contact but was comfortable with a hug and a cuddle some are not.
Within a week of taking 400mcg of Swanson Sulphoraphane in his morning juice, he changed dramatically. Eye contact, all the time, saying one or two words.
A year later, full sentences, says his alphabets, knows all his dinos, fully engaged and looks you straight in the eye. He is a very kind little boy and treats his little 3 y/o sister very well, even when she causes him trouble, he does not retaliate. She is on the spectrum as well but not as bad at her age as he was.
He is still autistic as this is not a ācureā but it sure makes a difference. When he misses a dose you can see it the next day. If he takes too much, he becomes overly emotional (sad scenes really bother him) when he is watching his fav TV show.
Dose makes a difference for him. Itās quite amazing.
As far as I understand, a sulforaphane supplement must contain both glucoraphanin and myrosinase. I looked up the label for the Swanson brand and itās unclear if it contains both.
Last I checked, BROQ/protaphane and Avmacol (and perhaps Broccomax which is suspiciously cheap) are the only sulforaphane supplements that have both.
Since Broq is considered the gold standard but costs more than $1 per day to get a serving, I havenāt been taking it.
Agree. On the other hand, hip fractures result in significant morbidity and mortality in the elderly. As a dentist, my advice is to only use these if you either have no teeth or super healthy teeth. If youāre on a bisphosphonate, thereās a risk of non-healing. If you really need bone density support, Iād recommend either Forteo (not used much as itās pricey and a daily injection) or Prolia, which only lasts about 6 months, so any oral surgery is safe if timed properly with the infusions. Floss!!
Deborah_Hall, Osteoporosis is one of the things Iām concerned about. I always thought an adequate diet and exercise would resolve any problems for me until I got an osteopenia report years ago. Iāve avoided the bisphosphenates for the reasons you cite and Iāve found no solutions other than continuing my diet + exercise routine. Have you done any research on HGH or peptides that increase HGH in connection with bone heatlh? I speak from ignorance, but I do wonder if low-dose HGH (or HGH promoting peptides) would improve bone density the way it would naturally take place.
