At last the first results of the much anticipated Lean Mass Hyper Responder (LMHR) plaque study are out.
For those who don’t know an LMHR is a phenotype defined has an LDL > 200mg/dl, HDL>80 and TG < 70.
These are generally lean athletic people on a Low Carbs diet. (Like me! )
TLDR: No issues due to very high LDL
It is an actual study. LMHR people with LDL 272mg/dl on average don’t have more plaque than those with normal LDL.
The second study will be at the end to compare the plaque progression rate in 1 year.
The studies on the linked website have a very weak methology. And where is the study looking at high levels of LDL-C and plaque mentioned in the videos?
Hypothesis-naive analyses were conducted on web survey data from 548 adults consuming a CRD. Univariate and multivariate regression models and regression trees were built to evaluate the interaction between body mass index (BMI) and baseline lipid markers.
We present the case of one subject, LM, who adopted a ketogenic diet for management of ulcerative colitis. He subsequently experienced an increase in LDL-C from 95 to 545 mg/dl, at peak, in association with HDL-C >100 mg/dl and triglycerides ~40 mg/dl, typical of the emergent LMHR phenotype. Assessments of LM’s dietary intake, lipid panels, and BMI are consistent with prior data and suggest that the LMHR phenomenon is not dependent on saturated fat intake but inversely associates with BMI changes. Finally, computed tomography angiography conducted on LM after over 2 years of hypercholesterolemia revealed no evidence of calcified or non-calcified plaque.
This study reports data from an n = 1 experiment, performed in duplicate, in which the subject consumed three ketogenic diets for 5 days that varied in caloric content: weight-maintenance (2278 kcal/day), hypo-caloric (1135 kcal/day), and hyper-caloric (4116 kcal/day). Consistent with the LEM, LDL-C and apolipoprotein B increased following caloric restriction and decreased following overfeeding, despite increased saturated fat consumption. Data from a case series of 24 individuals who underwent similar protocols similarly found that overfeeding on a ketogenic diet decreased LDL-C.
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