Thank you Deborah! Your personal experience is very helpful, so thank you for sharing.
I want to be on semaglutide for non weight related health benefits but didn’t know if low doses would blunt the health effects. It’s excellent to learn you are seeing results below a ‘theraputic’ dose.
I have since learned that for my brain (and bonus of glucose) goals, semaglutide is most likely the best option.
Thx again!
It is early days, still too early to say for certain that there is a trend. We shall see.
I wonder if the dosages prescribed are sometimes, often, higher than what is needed. 5 mg of Rosuvastatin does much of what a higher dose will do. Similarly, 5 mg of Exitimibe will do almost as much as 10mg. Also, prescribed dosing does not necessarily take into account individual make-ups and responsiveness. And we are still gathering data on how GLP1 drugs work. You can try starting with a super low dose and add more if you need to.
Took my first jab of Mounjaro yesterday. Low dose (2.5mg) as I’m ramping up as per guidelines. Going to take my 6mg Rapa tomorrow. Haven’t really felt massive hunger suppression yet, but it might take a while.
My question is: how have people anecdotally felt on both Rapa and Tirzepatide?
@Walter_Brown We did Rapa every 2 weeks at 6mg (EVOO + GFJ). Was doing that about 1 year before starting Tz. A couple months ago we increased our dose frequency to every week W1 6mg, W2 3mg, W3 6mg, and W4 3mg.
I don’t “feel” anything from Rapa.
But with Tz, yes there are some things that did change 
If you are doing this for weight management, take it slow and continue to follow the starter dose as developed over years of research by the people who spend hundreds of millions doing the clinical trials and are continuing to collect data from millions of patients.
I do agree that you may consider deviating from the clinically validated increases. We went from the 2.5mg starter dose to 3.5mg (instead of the 5mg step) because we both responded very well and lost about 5lb the first month. We then lost about 4lb a month consistently until we both plateaued at very acceptable weights.
I do recommend that people weigh themselves very day, first thing in the morning. But don’t worry about the small variations, they will happen, it’s the trend over time that matters and the more data points the better, IMHO.
Once you reach your goal weigh, consider tapering off to a maintenance dose if you start to go too low in weight.
We started Tirzepatide July 2023, lost about 35lbs in 9 months with a 3.5mg dose. Plateaued at 155 for 3 months and was super happy. Technically, that would have been our “maintenance” dose for that weight.
When we switched to Retatrutide in Feb 2024 at a lower 2.5mg dose, the weigh loss continued and I dropped another 15lbs, now at my HS grad weight, amazing! And have reduced to a maintenance dose of 2.0 mg. With Rt we find less appetite suppression and enjoy snacking again all while maintaining our youthful weigh profiles. Also more regular BM’s and the ability to enjoy a bigger meal every now and again and not feel uncomfortable.
I’ve posted a bit about the 3 more common GLP1-r’s and their different effects on appetite and the difference in how they enable weight loss.
Rt is the only one so far that actually burns fat through thermogenisis, the others work basically through caloric restriction, glucose and appetite control, which is obviously effective. But not like Rt
So we (my wife and I) don’t seem to have any issues personally with Rapa and at least 2 of the top GLP1-R’s for weight loss.
I have used compounded terzepatide. I felt nausea after a few days and after a week or 2 is when the satiety effects kicked in. I started at 2.5 mg weekly and worked up to 2.5 mg twice weekly. I take 4 mg of rapa every 3 weeks. I didn’t notice anything subjective from the mix.