If I were going for this sort of therapy I would really try to find a way of getting artificial plasma where you know what is in it.
Even if the issue is not IL-10 there is so much evidence that the problem is something in older blood rather than there being something in younger blood that is rejuvenating. Hence you need to start with water as add in various substances until you get usable quality plasma.
It remains I think there are better ways of dealing with senescence, but I can see this has some merit.
The problem with this is that people may not agree as to exactly what to do. Personally I think there are better approaches than acting on the plasma although I can see the arguments for so doing.
Thinking again what I am doing is changing the plasma, but through the digestive system rather than using needles.
Absolutely… it seems like the low hanging fruit might be regular, home-based TPE / plasmapheresis with 5% Albumin and a used equipment. I know you are concerned about blood products Joseph, does that include even 5% albumin? My understanding is that its highly processed and tested by Grifols and others in the industry.
Ok, an action plan might look something like this I suppose.
Purchases to be made/arranged:
Aphoresis equipment (cheap, from auction , used equipment vendor). Perhaps the cost could be split between a few people / friends in a given geographic area, and the equipment shared).
Validation process to make sure equipment is operating within spec. (perhaps identify local experts in the equipment to have them test and evaluate equipment purchased, prior to use)
Identify a complete and detailed “bill of materials” for all the specific consumables (specific to the apheresis device being used) needed for each plasmapheresis session (tubes, needles, filters, etc.).
Get prescription for albumin 5%, and other necessary add-ins to plasmapheresis (e.g. intravenous replacement of calcium and magnesium, etc.).
Identify and de-risk (plan activities to mitigate or obviate known risks and contraindications, and complications).
Learn venepuncture processes and procedures (are there classes/courses we can take at local medical schools for something like this?)
Identify local experts that can be hired for initial home processes.
Perhaps one of our community members who speaks russian can contact this group of similarly-minded Russian biohackers who have done all this before, and get their protocols and suggestions for home applications…
The easiest way, imho, to do it is donate plasma in a lab, then come home and inject yourself with the same amount of saline + 5% albumin using just a 4-leg IV stand to hold saline bags. Medline 4 Leg IV Poles Stand, 2 Hook, 4 Caster, Chrome, 47 to 85" Adjustable Height https://a.co/d/3aDjsZ6
It’s an easy way to do it at home. The only thing to learn is how to use catheter on your vein (and the basics of asepsis/antisepsis).
When you donate plasma request/insisted a catheter be used and leave in place{or do not donate, your negotiation stance] flush with heparin flush. When you get home re-infuse/infuse your solution, connect to the catheter.
You can remove cather, or leave in a few days{as long as you flush once per 24 hours with heparin flush.
You can infuse other supplements for a few days and not have to be re-stuck.
Do you mean saline vs plasma? It’s more neutral and the point is to dilute, not to receive more plasma. I would use Ringer’s saline. Plasma will restore naturally after donation in couple days.
Appreciate the math. In my case, as a 175 pound male, they took about 890ml of plasma per donation, which I estimated to be 29% of my total plasma. I even tried donating Monday evening and Wednesday morning to shorten the window between donations. One way around the 5 day window is to try to do it at 2 different companies without telling them. However, they do visual arm checks for bruising and if discovered you will be permanently banned. You would also need to live in an urban area that had 2 providers.
( bring your own albumin)