Why take Lithium at bedtime?
I take all my supplements with a glass of milk and crash⌠letting them slowly abdorb while I sleep.
They donât cause any issues in sleep quality. Last thing I do at night.
Nothing really actionable in this video. Largely an ad to hype paying $19.99 / mo. to join his âPsysionic Insidersâ channel to even find out what type of lithium to use. He also points out that studies used 300-400ug of lithium. Nick Norwitz piece is better; he says heâs taking 5mg or lithium orotate daily (but doesnât address the 5mg elemental lithium v. ~130mg lithium orotate discussion which has been addressed here).
I thought the images of brain plaques in the mice were interesting. You always need to ignore the request to become a physionic insider in his videos.
I also take it at bedtime as Iâm taking dapagliflozin in the morning (SGLT2is lower lithium levels) and telmisartan in the evening (increases lithium levels). If lithium acts by clearing amyloid then it might be better to do that at night which is when a lot of clearing is done? In Defense Of The Amyloid Hypothesis
However, lithium orotate has a long half-life so it shouldnât matter that much.
Lithium itself does not get metabolised. Hence it is entirely an excretion issue.
Yes, SGLT2 inhibitors enhance the renal excretion of lithium: âFractional lithium excretion increased by 19.6% (from 6.7 to 34.2; p < 0.01), suggesting inhibition of sodium reabsorption in the proximal tubule.â (Effects of Dapagliflozin on Volume Status When Added to Renin-Angiotensin System Inhibitors 2019)
Telmisartan lowers lithium renal excretion, but itâs unclear by how much (about -26% for ACEIs: Lithium and angiotensin-converting enzyme inhibitors: evaluation of a potential interaction - PubMed )
I donât think the body has a target for lithium levels unlike sodium. Hence the excretion will be heavily linked to the serum levels.
How much Lithium did you say you were taking personally in case I missed it?
Lithium orotate 1 mg: Lithium, 1000 mcg, 100 capsules - - Life Extension
I might try 5 mg. For now, 1 mg does the job for me (I notice it when I donât take it).
Before that, I tried lithium gluconate and lithium citrate, the only forms available OTC in France (also 1 mg). Orotate felt more potent, and I kept using it. The recent paper confirms my subjective feeling.
Please elaborate âyou notice when you donât take itâ.
Seems like a wide range of dosing from 1 mg to 10 mg.
I already mentioned it here: when I donât take lithium Iâm more sensitive to day-to-day stress. Letâs say you have an appointment for something and youâre stuck in traffic and you know youâll arrive late, maybe by a few minutes, maybe so much that youâll miss the appointment. Without lithium I would be worried, try to look at alternatives, with lithium Iâm a bit in a âthatâs life and I canât do anythingâ mode. Thatâs the best analogy I can find. It makes my life smoother. On days with actual stress I tried 2 mg and it seems that the effect are dose dependent. Others here mentioned a similar feeling.
In terms of cognition I havenât seen benefits but itâs hard to measure and in any case Iâm sure that stress negatively affects cognition in the long run.
Puts up glucose. Increases ROS.
Are you saying stress increases glucose and ROS, or lithium does? Just to clarify.
Stress which tends to involve cortisol increases glucose.
Where do Ergothionienes (e.g., Maitake and other mushrooms) fit with Lithium in the cognition paradigm.
Any synergies or antagonism? Or, ergo alone is sufficient?