This link sent me to an error page
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Well just search on Google Scholar āLithiumā AND āStrawbridgeā as author.
Jeezā¦Iām not going to spoon feed you!!
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Youāre right. Thanks for sharing. This is certainly helpful.
fixed link here Lithium: how low can you go? - PMC (nih.gov)
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I havenāt read that paper (yet), but do note that goals for bipolar disease even at the low end might be higher than what you want for longevity. See e.g. posts by john hemming on the topic on the forum and/or see how low Bryan Johnsonās dose it.
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I felt that there was a bigger impact at 5 mg vs 1 mg. Of course, it could all be the placebo effect, but when dealing with a psychological effect in the first place, it may be an important part of the supplement.
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WNT is not necessarily psychological. I did notice a buzz from starting Lithium, however.
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So I just did a lithium blood test. It is called āLithium (Eskalith R) Serumā
My result is LOW <0.1. The reference range is 0.5-1.2nmol
Was that the correct test and does that mean I should supplement with lithium orotate, and if so, how much should I take?
I would be surprised if the range is nano moles.
Actually now that I think of it, the lab range is probably for people who take lithium medication, right?
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That it what people discussed earlier on the forum
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Sorry I double checked. The lab range/result is in mmol. Not nmol
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Thanks. Generally tests I have seen cannot measure much below 50-100 microMolar. Being as I am to be something in the sub 50 micro molar range that is a bit of a nuisance, but as yet this is an inexact science anyway.
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Ok Iām ordering it. Iāve dosed 1-5mg before but only stopped a couple months ago so Iāll hop back on.
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Some tap water studies contradict others, for instance: Lowālevel lithium in drinking water and subsequent risk of dementia: Cohort study 2023
Lithium levels were positively associated with the risk of dementia in women (highest in second quartile, HR 1.17, 95%CI 1.04ā1.32), but there was no relationship in men (highest in second quartile, HR 0.95, 95% CI 0.81ā1.12). The pattern of association was explored further by decile, and in females there was an association between lithium level and increased dementia risk compared to the lowest decile (0.55ā0.68 Ī¼g/L) in all deciles except the highest, corresponding with lithium levels 0.68ā2.1 Ī¼g/L.
Lithium levels in drinking water are very low across Scotland which limited detection of potential effect. Our results do not support an association between extremely low levels of lithium and later dementia risk. We found a trend to increased risk in females at lithium levels below but not above 2.1 Ī¼g/L.
The adjusted model showed a significant inverse association of lithium levels with female, but not with male, or total prevalence of AD.
Also diverging results when it comes to longitudinal studies looking at high-dose lithium therapy in psychiatry:
The forest plot results showed that taking lithium therapy reduced the risk of AD (RR 0.59, 95% confidence interval [CI]: 0.44ā0.78) and is also protective in reducing the risk of dementia (RR 0.66, 95% CI: 0.56ā0.77). The duration of lithium therapy was able to affect dementia incidence (RR 0.70, 95% CI: 0.55ā0.88); however, it is unclear how this effect might manifest in AD.
Lithium and risk of cardiovascular disease, dementia and venous thromboembolism 2023
Regarding neurological disorders, lithium treatment was associated with higher risk for dementia (HR = 2.64, 99% CI = 2.38ā2.94) and Parkinsonās disease (HR = 3.82, 99% CI = 3.13ā4.66), seizures (HR = 2.32, 99% CI = 2.04ā2.63) and collapse (HR = 1.54, 99% CI = 1.32ā1.79)
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From your cited paper:
āWe conclude that individuals prescribed lithium have a lower risk of cardiovascular and cerebrovascular disease, but no marked effect on dementia, compared to individuals with a mood or psychotic disorder not prescribed lithium. Venous thromboembolism, Parkinsonās disease, and kidney disease were significantly more prevalent in individuals prescribed lithium.ā
Prescribed doses of lithium are generally an order of magnitudes higher than the 5 to 20 mg of lithium orotate advocated by many in the forum
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Yes, thatās what I wrote. But itās still interesting. And on the other hand, the water studies at very low doses (but over a long period of time most likely) find negative or neutral results in men.
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Higher dose lithium inhibits some citrate transporters and i think that is what can cause nephrotoxicity
Blood serum has a normal level of citrate.
Chinese paper on lithium & AD: Frontiers | Molecular mechanisms and therapeutic potential of lithium in Alzheimerās disease: repurposing an old class of drugs
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Thank you for that article. I plan to publish my blog on AD/PD and Lithium on Monday. It seems like a relatively benign therapy both preventive and escalating the dose when there is disease.
The issue with these conditions, both preventive and to treat disease is how much of the efficacy is overlapping with other agents, as many have similar proposed mechanisms.
Once someone has disease, Iām probably more keen to have 5 or 6 items that have low side effect profiles that have evidence, and I think Lithium will probably be part of those 5 or 6.
I have an ApoE3/E4 and Iām pretty much taking 6 items that I feel have minimal risk, and speculative benefit.
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