I don’t know. The IC50 is 90 microMolar which is weaker than berberine/quercetin etc.
There are quite a lot of HDAC inhibitors around and I take a mixture. In fact I am running some experiments cycling HDAC inibition as well as acetyl-CoA levels. Hence I have a day on relatively low levels then a day with higher levels.
I am a little concerned about the side effects of high levels of an HDAC (not on the histone, but other side effects) hence I think cycling might be best.
The ones I am using have relatively short half lives (around 4-10 hours). Pterostilbene is quite long at 105 even longer than Rapamycin, however.
Ironically it appears that Resveratrol’s main effect might be as an HDAC inhibitor in that it actually inhibits the sirtuins.
In the end the question with HDAC inibitors is quite complex because you have the IC50, the bioavailability, the half life and the dose. In the end it is probably really something which can only be worked out finally through experimentation.
You can see it in this photograph where the timing of the start of hair growth is indicated by the length of the hair. Two phases of high HDAC usage (and the rest of my stack which is quite complicated) have caused additional facial hair to start up.