I do have a preferred Nattokinase vendor 
I’ve been purchasing from Belle Chemical for 4 years, great product.
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Steve,how do you manage taking the powder on an empty stomach?
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This powder is pretty innocuous, no bad flavour. I have this in my super shake every morning. But when I skip my shake I just put it in water and stir it up and drink it down.
I have a cast iron constitution (as they say), not much bothers my gut but this stuff is not difficult to consume anyway.
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I was under the impression that proteolytic enzymes need to be taken on an empty stomach, otherwise they just get wasted on digesting proteins in the stomach contents(?).
I’d hate for you to be wasting it in the smoothies, but I guess if you’re buying it in bulk you’ve got plenty to spare.
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I have not done that since I started taking Nattokinase 4 years ago. I think you do bring up a valid point but I have not seen definitive clinical info on either side of this. Mostly speculative commentary based on the “proteolytic” aspect. It does appear to be sensitive to high gastric acid so an empty stomach first thing in the morning has the highest levels of gastric acid…
When people eat Natto as part of their diet, I doubt it’s on an empty stomach and probably part of a meal with more to it than just the natto.?? where benefits have been evaluated in population studies,
This is the study I referenced previously and I can’t see if they used it with or without food. It’s benefits do seem to be very dose dependent which may reflect the consumption protocol.
This one is related to Osteo
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Is that independent of any effect on weight loss? Source or graph if you mind? Just curious.
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This is likely impossible to distinguish given that there’s always dramatic weight loss in the published studies. Since incretins don’t have any direct effect on lipids it has to be the loss of liver fat that does it (thus no effect on lipids if visceral fat is already low).
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It may be indeed due to dramatic decreases in liver fat, here are several graphs detailing it:
- average liver fqat reduction of 50% after 48 weeks on those on 1mg and up
- liver fat reduction of 30% were achieved by at least 71% of patients, reduction of >50% was achieved by at least 43%, liver fat reduction of >70% by at least 22% of patients. 80% of patients on the highest dose achieved liver fat reduction of >70%
- by week 24, at least 27% had a liver fat content of <5%
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Interesting, I’ve heard that the body protects the liver with increases in saturated fat intake by dumping LDL-C into the blood stream, which is why serum LDL-C increases with saturated fats. I don’t know how true this is. But SFA intake is related to liver fat, and LDL-C.
Here are the numbers for apob changes. It’s actually a 24% decrease of apob, not 40% (I was thinking of triglicerides)
This is from a talk at EASD 2024: e-Science
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UDCA might help for osteoarthritis: UDCA (ursodiol) / TUDCA for healthspan and lifespan? - #55 by adssx
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