Insulin resistance explained

There is at least person on this site who is getting younger by some measures.

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Maybe you have to have used Sci-hub before:

You can click any of the sci-hub links to get a page with a box on it. Put the DOI number for the study in the box. You can find the DOI usually under the title of the study. They all have one. If you have the title of the study or authors, then using google scholar will get you the DOI. Paste it into the box and hit go. Sci hub will try to steal the paper for you.

The papers are paid for by the public and maybe you remember when Aaron Swartz figured out how to steal them and make them public? He was a hacker and activist that helped get Reddit started. Anyway they caught him and threw him in jail and he hung himself. Later a woman from I think Kasakhstan actually figured out how to do it and has managed to stay a step ahead for years now. Sci Hub is great but doesn’t always work. If it’s on Science Direct it almost always does.

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Actually, Red Mill wheat germ is raw. It should be cooked to inactivate the lectins, I’d assume. But cooking would change the nutrients including spermadine, I’d bet. What a conundrum…

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Wheat is also the leading cause of discomfort when taking acarbose. Really, for me, the difference is between night and day. When I avoid any wheat products the acarbose produces little or no gas.


I’ve paused my use of wheat germ until I can get to the bottom of this question. I’ll use chlorella for spermadine for now.

Lustgarten’s latest video:

Talks about his book. He was asked directly if there was any food that would cause the gut barrier to get worse and he didn’t come up with anything. He didn’t say “WHEAT” or “Oats” or “corn” or anything for that matter. So maybe I’m crazy, but he’s not really the lectin guy.

Good video though.

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Here’s the next video on Insulin Resistance by Mario Kratz PhD. This guy is very good. In this video he provides more detail on what is happening to each person over time as they become more insulin resistant for various reasons (body fat, sedentary, stress, sleep, etc.), until they eventually bump into their personal insulin production limit, which is different for each person. He also speaks to an emerging area of research on brain-controlled reaction to higher glucose.


I can’t imagine that an obese person would be metabolically healthy. Glucose and insulin is just a part of metabolic health.

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I’ve read his book and found it interesting. What I wonder about is whether a potential modest increase in microbial burden resulting from things like leaky gut, or poor skin barrier, is sufficient to have any significant effects on insulin resistance. Injecting people with LPS potentially gives them a huge dose of LPS which they probably won’t experience unless they are sick with a bacterial infection. LPS probably changes a lot less in response merely to changes in barrier function so I consider the link between LPS and insulin resistance highly theoretical unless I see more proof.

I strongly suspect I had IR for a long time before my heart attack, even though I was probably at around 15% BF. Stress was probably part of it but also eating poorly, which I thought I didn’t have to worry about because I was getting a lot of exercise. Attention to diet - especially elimination of carbs and fast food - has kept my HOMA-IR and CRP well under the “normal” range indicated above.

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I think it’s a common mistake to think that burning calories means they didn’t count. I’ve made that mistake in my past as well. I’m particularly interested in AGEs directly and indirectly from the diet contributing to “aging” via damage to systems which no longer work properly.

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I know. I keep thinking my doctor is going to offer to check my LPS and see how my microbial burden is going. Lol, not happening. Next time I see my doctor I’ll ask to test my LPS and report what he says. It’ll be January. Just for giggles.

If it was easy to test, then I’d think it would be happening. You’d see the correlation with practice.

It makes so much sense because oral bacteria are found at the base of the plaque which indicates that they have started the ball rolling toward heart disease. I learned that elsewhere, I think from Malcolm Kendrick. But it fits so well with this.

So this is a rare book that actually opens my eyes to something I had really no knowledge. Avoid deficiency in vitamin and mineral and polyphenol, also hygiene. Cultivate a microbiome in oral and gut that keeps the bad guys at bay.

The problems are similar to farming in that we have tools that can really move you in the wrong direction (tillage kills weeds, also important mycorrhizal fungus). Using mouthwash can kill the bacteria that convert nitrate to nitrite. It screws things up. Also the gut microbiome is easy to move in the wrong direction with antibiotics or lectins or just bad diet. We have little to tell us if a problem is coming, and no guidance on how to fix it. This is an important area that is a work in progress.