I have been using tretinoin since the late sixties (!) when I was a student at the University of Pennsylvania and participated in a trial of tretinoin for controlling acne – which it does. Just kept on using it, off and on, throughout the acne years and into the aging years. Now 75 and still using tretinoin --not every day, but consistently. It is on my fairly short list of things that really deliver, with no adverse effects.
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I agree, tretinoin works. Everything else is second best.
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