one current hypothesis is that solutes and interstitial fluid leave the brain through intramural peri-arterial drainage (IPAD) pathways.
The study Dr. Carare describes provides evidence for this theory and even a potential explanation and process for the build up of amyloid beta in Alzheimer’s disease. The results suggest that therapies that involve transferring medicine via cerebrospinal fluid may be a suitable option in treating some neurological disorders.