Ideas and Participation in ITP Longevity Drug Applications for 2026?

#22

February 27th. I’m working on a couple.

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#23

Do you have any tips for writing a submission? I’ve never done one before.

#24

I’ve not done one either. I’m just going to start with the prompt and then edit from there to clean it up and make sure it makes sense: Ideas and Participation in ITP Longevity Drug Applications for 2026? - #2 by RapAdmin

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#25

I get a feeling that a submission for ITP can easily be translated to a submission to CITP and vice versa.

I will post my CIPT submission here when it is done for input.

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#26

Glucosamine SO4 (Gsa), Taurine (Tau), Urolithin A (Uro) are tested in the 2025

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#27

orforglipron CITP proposal.pdf (120.9 KB)

#28

These are big ones because I’m always on the fence about taking them. I’m only taking taurine now but was taking glucosamine for a while.

#29

I totally agree that the focus should be on things that are easily available and I don’t think it’s selfish, even though, yes I certainly do want that information for myself. I think it’s simply rational to first look at treatments that are available so we can identify low hanging fruit to use now that will then give us more time alive to identify other treatments that won’t be available until later anyways. This is especially true since the end goal is to make use of whatever we find to extend the lifespan of humans, not just lab animals.

My first question when considering any candidate intervention is: If it actually ends up extending lifespan of mice in the ITP, is that going to help us right now, or is that information only indirectly beneficial or beneficial much later.

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#30

If it’s available now we can use it now. If it is successful it will also encourage further studies being done on larger creatures and humans.

I also encourage anyone who wants a molecule tested to do their own submission to the ITP.

I’m doing Orforglipron. Anyone else who is doing a submission should state what molecule they are doing one for here.

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#31

How are we deciding what supplier for the chemicals to choose? I can’t tell which ones are good and which ones are bad and prices vary. I hope that if the rest of the proposal I make is good but they don’t like the supplier they can find another one more suitable.

#32

Intra nasal insulin

#33

Sigma Aldrich / Millapore Sigma is the largest supplier in the US - just use them as a benchmark price: https://www.sigmaaldrich.com/US/

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#34

Orforglipron application has been sent off!

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#35

Please post a PDF of your application (with personal details redacted), if you can. I’ll do the same for mine once I finish them.

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#36

Here is the application minus personal data. I removed the first page, the biosketch and my signature.
anonymized orforglipron ITP application.pdf (685.5 KB)
I’d be interested in feedback. I spent about a week on it so hopefully it is professional enough that it conveys the point.

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#37

A reminder that the deadline for our ITP applications is quickly approaching.

#38

Using that prompt I made makes this really easy… about 40 minutes per ITP application (or less, it gets easier and faster each time). If other people have ideas, I recommend you put a little time in and make the submission. Here are my three submissions (I may do more):

Imeglimin ITP Application Proposal.pdf (85.9 KB)
MA-5 ITP Application Discussion.pdf (79.6 KB)
Dapansutrile ITP Study Proposal.pdf (102.0 KB)

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#39

And one last submission… (note, the above were all earlier drafts). So, a total of 4 drug submissions to the ITP for me. Anyone else send any in?

Maraviroc ITP Application Draft.pdf (122.0 KB)

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#40

Well done. I’ve never done this before, any idea on approximately how long until we find out if our submissions were accepted/rejected?

#41

ferulic_acid_ITP_anonymous.pdf (151.1 KB)
This is my application.

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