How to Reverse Skin Aging

Have you tried dutasteride? Some people report feeling no sides on dutasteride when they couldn’t take finasteride.

2 Likes

Sadly, I’m just a dud when it comes of 5ar inhibitors. Dutasteride gave me unbelievable migraines that woke me up at night. I have thought about maybe trying topical or mesotherapy dutasteride but I’ve never gotten around to it.

3 Likes

Does anyone know more about DNA repair enzymes in topical skincare products? Allegedly reduces both photoaging AND skin cancer risk - although more research is needed to confirm the last part, see Six critical questions for DNA repair enzymes in skincare products: a review in dialog - PMC

On the hunt for a product, but the Aussie dollar is weak at the moment, and everything seems to be priced in US dollars… Would be good to get the views of anyone that’s done a deep dive on this. Seems to good to be true, but over to the brains trust

1 Like

Look into AR antagonists (e.g pyrilutamide, darolutamide) and AR PROTACs (e.g bavdegalutamide). Pyrilutamide is sold openly on the grey market, but you should absolutely test for legitimacy. Darolutamide and bavdegalutamide can be purchased by companies for research, but resourceful individuals can bypass this with minimal extra effort. Of course you can always try China, but then test everything twice.

Although pyrilutamide failed phase III, it’s likely this was due to the low concentration used, as the AR antagonist RU-58841 has a plethora of anecdotal success stories. Additionally, the AR PROTAC GT-20029 has recently passed phase II trials with good tolerability. PROTAC drugs work by targeting the protein they bind to (in this case the AR) for proteolysis.

2 Likes

I had good results from just a few months on adapolene. Acne reduced from not much to near zero, shaving rash significantly reduced, blackheads reduced, fine lines reduced, forehead expression lines less deep. I will say it required me to moisturise 2-3 times a day for the first few months.

I used tretinoin off an on for a couple of years, but I don’t think I saw any benefit and I couldn’t really tolerate it. It always caused redness and I never got past the starting dose of a a tiny bit once a week.
I tolerated adapolene much better from the start. Maybe a bit of sensitivity in the eyelids at first.

4 Likes

@Beth thanks for the recommendation, I ended up going with Dermatica

2 Likes

EXCELLENT! I hope you like it. That is exactly what I have. My skin seems to like more than other forms I’ve tried.

1 Like
1 Like
1 Like