According to a review on hesperidin, the gut microbial rhamnosidases in the small intestine and mainly in the colon hydrolyze hesperidin into aglycone form (hesperetin), which is then converted to glucuronides in the large intestine ². The study also suggests that the composition of gut microbiota affects the bioavailability of hesperidin ¹.
Finasteride can still have a significant impact at doses as low as 0.2 mg. I would also consider red light therapy, topical rapamycin, topical treintoin, topical spironolactone, topical ketoconazole and topical tacrolimus. Combo therapy may have a multiplier effect, but not a lot of studies to confirm that.
Topical tacrolimus is a medication that is used to treat moderate to severe eczema, a chronic inflammatory skin condition¹². It works by suppressing the immune system and reducing the inflammation in the affected skin³. It is usually prescribed as an alternative to steroid creams or ointments, which can cause skin thinning or other side effects with long-term use¹⁴.
Topical tacrolimus can be effective for improving the symptoms of eczema, such as redness, itching, and scaling⁵. However, it is not a cure for eczema and it is not for long-term use. It should only be used on skin that is affected by eczema and under the guidance of a doctor¹³.
Topical tacrolimus may also have some risks and side effects, such as burning, stinging, or infection of the treated skin, increased sensitivity to sunlight, or increased risk of skin cancer or lymphoma¹³. Therefore, it is important to follow the instructions for using this medication carefully and to report any unusual or severe symptoms to your doctor. You should also avoid eating grapefruit or drinking grapefruit juice while using this medication, as it may affect how it works in your body¹³.
I hope this information is helpful. If you have any questions or concerns, please consult your doctor or pharmacist before using topical tacrolimus.
For most people this is bad advice. Even if you get a hair transplant, you’ll continue to lose ground unless you take finasteride. Donor hair is not an infinite resource.
Just start with a small amount (0.25mg/day) if you’re worried about side effects. Work your way up to 1mg/day and if you do notice side effects, you can scale back the dose.
This is my bald patch today. I wonder if I have now finally got most of the follicles (in this area) to re-engage with hair production. Its a slow process, but it does not involve fin, dut or hair transplants.
Most importantly it fits in with the two key aging mechanisms so is a more visual representation of other somatic changes.
I see some darker hairs but not new regrowth. Clearly what you’re doing is not powerful enough to combat the negative effects of DHT or your hair follicles have already died off.
The hair follicles get miniaturised and what is happening is that this process is reversing. I do have better comparative photos for the same location.
The single starting hair on the middle leftish of this image from May 2023, is the long out of focus hair in the front of the image above.
The depth of focus of the macro camera is quite limited.
In essence what DHT does is to damage the mitochondria so that the cells cannot produce the right proteins. Also senescence comes in and different types of hair cell do not differentiate properly.
Senescence is caused by a shortage of acetyl-CoA at the key stage and I am dealing with that by improving transcription. Separately I am working on improving mitochondrial efficiency. This affects all cells, but on the scalp it causes the reversal of miniaturisation.
Firstly I get fine weak hairs called vellus hairs, those then change into fine pigmented hairs. As the mitochondria get stronger the hairs get thicker. Sometimes new hairs start up either very strong (that is rare, but does happen), but often as not particulaly thick, not not fine either.
It is a slow process that is in a sense similar to hair receding save that it advances. Very slowly though. However, I am not sure I would wish to try to speed it up as improving mitochondria means mainly autophagy.
If you look carefully at the photo you will see a small number of hairs have fallen out as well. That may be from strong brushing, but it may be simply the normal hair cycle.
Dutasteride mesotherapy works because it targets the root cause of AGA without going systemic although studies suggests it is somewhat less effective than using finasteride. PRP is more of a growth simulant on top of that.
Do you think oral finasteride is viable for lifelong prevention or does it has time limit when its effectiveness expires? I have a friend who was using finasteride for years and years (he started soon after it was approved for hair loss) for his diffuse hair loss and it was very effective for long time but lately his hair loss is gaining momentum again.
There are at least 3 separate 10 year follow up studies proving finasteride’s continued efficiacy in ~90% of subjects, with a sizable portion of those men having regrowth even at the 10 year mark. Extrapolating from that data, I would say that finasteride will likely keep your hair for decades at the very least. Even in the worst case, you will never bald completely.
I have used tacrolimus for eczema in my practice for decades It’s safe in spite of the PI warnings (remember the PI warnings for topical is taken from oral medication warnings). My patients seemed to do well with it and didn’t suffer the skin thinning and pigmentation issues that you would get from chronic topical steroid use. It never occurred to me that it could actually increase collagen synthesis… most eczema patients are children, they have plenty of well organized collagen.
It seems that anti-inflammatory agents in general have anti-aging effects, especially in older adults although you have to be careful with broad spectrum agents like topical corticosteroids.
Hey @Sylwia_CC , how did you get on with these injectables for collagen? Did you work out which ones worked best in the end? I was looking forward to your update but can’t see it on here. Thanks!
In case it helps, Oneskin is now shipping to the UK, duty paid:
Do you offer international shipping?
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For shipments outside of the United States, we ship DDP (with duties paid). Shipping duties and taxes are all included in the final price you see at checkout.
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