Anyone know what they used to deliver it deep in the skin, the main delivery chemical in the cream? Asking for a friend 
This article summarizes the Drexel study posted elsewhere on the forum. The snippet below from the paper says the placebo was a DMSO cream, so I’m guessing DMSO was also used as a vehicle for the Rapa.
Participants enrolled in the study were provided with a container of rapamycin cream and a container of placebo (DMSO) in identical dispensers with labels for right or left hand and were instructed to apply the creams 0.5 cc (1 pump from the dispenser) to the dorsal side of each hand every 24 to 48 h in the evening before bed.
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The present study provides for the first time characterization of a 0.1% rapamycin cream formulation presenting good rapamycin solubilisation. The first step of the formulation is solubilisation of rapamycin in Transcutol1, and the second step is the incorporation of the mixture in an oil-in-water cream.
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I understand the debate on DMSO and Transcutol with respect to being better absorbed into the blood stream with DMSO, but doesn’t it seem like they used DMSO in the Drexel study? Would they really have used Transcutol in the rapamycin formulation, and DMSO for the placebo?
From Materials and Methods section, the only place they mention DMSO
Participants enrolled in the study were provided with a container of rapamycin cream and a container of placebo (DMSO)
From the caption of Figure 1.
Topical rapamycin treatment reduces expression of the senescence regulator p16INK4A. Human skin was treated with a formulation of 10 μM rapamycin or an identical formulation containing a vehicle control for 6–8 months; 0.5 cc of formulation was applied daily.
They may have used DMSO in both the control and the cream, but there are some issues with DMSO, read this post: Rapamycin for Hair Growth and Hair Pigmentation - #320 by RapAdmin
It seems like transcutol is more often used in commercial derm formulations.
Note that the rapamycin is at least partial dissolved in a variety of oils. Mixing Transcutol, rapamycin and any of the oils will result in less rapamcyin penetrating the skin. Just say’n.
This might be acceptable to some people but we really don’t know how much the oils mixed with Transcutol affect the ability of the mixture to penetrate the dermal layers.
I am having very good results from taking rapamycin and using the mixture of Transcutol, rapamycin and water as a spray mist. I believe this allows for the Trancutol to carry rapamycin deeper into the skin.
The result of using this mixture on my head and hands has dramatically reduced appearances of actinic keratoses and a reduction of age spots on my hands. The reduction of age spots is one of the only “age reversal” properties of rapamycin that I have experienced as opposed to merely delaying aging.
I have recently added metformin to the mixture but haven’t seen any differences yet. I might have to increase the amount of metformin in the mixture.
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Does anyone know where Ultrahilo can be purchased?
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Just search on google shopping (or click on this link):
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I bought it at cosmokorea.com. Delivery was very fast - 3-4 days only ($47 by FedEx). The price was $90 after 10% discount. The payment method was through WISE (bank transfer) with a small additional fee. It took couple hours to set up an account with WISE and get verified. After that finalizing purchase was fast.
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Didn’t use it yet, but plan on using it soon. Will report after that. Unfortunately, cosmokorea doesn’t provide any recommendations on the best method to use (or at least I cannot find anything besides 1 video on YouTube).
Please don’t do it yourself 
I would really advise against it. Injecting hyaluronic acid you should be really knowledgable in skin anatomy to inject it in the right skin layer and avoid any blood vessels since you can cause occlusions and consequently tissue death.
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Maybe you are right. How do you make you spray? Do you use it daily?
From this Twitter thread https://twitter.com/adanguyenx/status/1656700890253000704?s=20
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Here - Denitsa Milanova on MRBL – Gene Therapy for Skin Rejuvenation
It’s a little strange advice for this forum. Most of us use different prescription medications without scripts 
Injections are superficial - 4 mm max depth. I do similar treatments for many years without any complications (I did have a formal training though long time ago). Doing the same procedure at a doctor’s isn’t a guarantee that all will go without complications. Every time I tried the same with a dermatologist would leave me all bruised for a long time. It was a reason why I started doing it myself - nobody knows my skin and face anatomy better than I do.
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Thank you for your concern. I truly appreciate it. Although I’m not a doctor I’ve worked in the medical field for over 25 years doing all kinds of sticks and blood draws etc so I’m either going to give it a go or take it to my nurse friend that does similar cosmetic type procedures.
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Maybe I am a little paranoid as a result of living with a plastic surgeon and all the training he has done and is doing and hearing sometimes horror stories of self injecting or going to a badly or untrained doctor (or nurse) and how they are trying to fix those things in hospital. I also work in medical field although not in the immediate sense of the word but the first thing that comes to me is always Primum non nocere (first do no harm) and I go by this even for myself. Even when trying off label medicines I have this in my mind. I also understand that some cosmetic treatments have a ridiculous “mark up” as this field of medicine is in its roots for-profit and it makes you more drawn to DIY solutions, but I just wanted to point out that it can get out of hands. Profhilo/Ultrahilo can cause vascular occlusions. Doctors usually have hyaluronidase on hand to intervene quickly. There are late occlusions possibe, when symptoms would appear later. Just be careful.
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