Of course, you should be cautious, but that is common. Often the only party interested in funding the studies is the company with something to sell. He is a reputable scientist, however. He also has patents on these products, including the ones you are suggesting we should make it home!
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It is “patent pending” 
I am just an end user. We have one famous physician that posts here. She prescribes this scam supplement to her patients when warranted. Perhaps you should give her the benefit of your “research”, lol.
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Here’s a good synopsis I found on Profhilo, nucleofill, and Rejuran. I didn’t do a deep search on availability, but I saw that Ultrahilo is available on Indiamart for $50 per box.
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You know, I am European, and heath and medicine in most part is not yet business and for profit and whenever a doctor suggest a very expensive supplement I am wary. I am not disputing that there might be something in nitric oxide supplementation I was just saying that taking a really cheap ingredients like vitamin C and sodium nitrite if indeed is beneficial in so many ways should be made available for a reasonable price not priced to make someone rich. But since the one researching and getting rich from this same research which hasn’t really been confirmed by other independent researchers makes me even more cautious.
But it wouldn’t be the only case in this world where money and profit is above ethics and common good. And let’s leave at that. I did not say that you should not use/take this product at the end it is your money and people use it for far useless purposes than trying a supplement that may or may not work and I wish you best results with it but I wanted to point out that all that glitters is not gold.
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It requires 5 (stinging) injections on each side of your face. I go to the practitioner. But ppl who are comfortable with giving injections, like nurse, can do it by themselves i guess.
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The one I know is called Seventy Hyal. And my Korean friends recommend it. I will tell you what I think in a few months. Also I plan having Rejuran healer done on my décolleté.
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Bryan Johnson is now using Fontana Laser, he says:
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Darn, I’m sure there’s no home version of that one for us commoners!
Laser Face Lifting: Fotona 4D is the most effective non-invasive facelift, which is a combination of 4 methods of laser exposure to tissues outside and in the oral cavity. These technologies enhance each other’s action, allowing you to get an impressive result of rejuvenation and lifting without a long recovery period. Laser 4D rejuvenation is:
-multilevel laser lifting skin rejuvenation to the deep layers of the dermis
-correction of problems of the “nasolabial triangle”
-smoothing of the skin
Price: $1200 (including home care products)
Liplase: The Fotona laser is performed not only externally from the surface of the skin, but also from the side of the oral cavity – the mucous membrane of the cheeks and lips without damaging its surface. As a result, the laser affects the entire thickness of tissues: the surface of the skin of the face, subcutaneous fat, muscles, and most importantly, the ligamentous apparatus of the face, which provides a powerful tightening (lifting) effect.
Price $299
SmoothEye®: is a new and exciting non-ablative treatment for tightening of the area around the eyes and reducing the appearance of wrinkles, eye bags, and dark circles. SmoothEye® significantly tightens loose and aging skin of the eyelids and peri ocular region with little-to-no downtime and maximum patient comfort, making this a very sought after non-invasive cosmetic procedure. After a few treatment sessions, the result is improved skin elasticity, overall structure, and volume with significant wrinkle reduction.
Price $399 for one session / $960 for pack of three sessions
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I feel like Bryan Johnson is overdoing IPL and now he’s adding Fotona…
Nowadays more and more companies are making at-home devices. So just wait a few years and there will be some at-home version of these expensive in-office treatments.
There is an at-home laser device called Nira. Reviews have been good - there are plenty of videos on YouTube. It’s currently sold out. I may get it at Black Friday.
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How is that different than NIR LED’s. Light is light, right?
There are issues about frequency, intensity and total energy. If the intensity is too low nothing happens, if it is too high damage is caused if the energy is too high damage is caused, The effect varies by frequency.
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From Nira’s website:
How does Nira compare to professional fractional laser treatments at med-spa?
Most dermatologists use fractional lasers at wavelengths up to 1550 nm. NIRA uses the same semiconductor laser diodes tuned at 1450 nm which allows peak absorption in the dermis layers. NIRA uses a lower power per unit area and a non-fractional approach to avoid pain and redness and spreads the energy over daily treatments over time, whereas the dermatologist typically treats with all the energy in one visit per month. Over time, the NIRA device puts in more energy than most professional treatments do in a single visit and NIRA generates equal or more skin rejuvenation.
The NIRA Precision Laser reverses the impact of aging by transmitting a non-fractional laser fluence to gently heat the dermis above the point of heat-shock protein (HSP) formation and just below the pain threshold.
This stimulates natural collagen production to plump skin and smooth wrinkles without any pain or downtime for firmer, youthful looking skin.
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Kandice - you seem to be right, there are a number of devices like this that are new to the market… and the entire “light therapy” market seems to be exploding with products (red light therapy, etc.).
The NIRA skin product seems to list around $399
and here is another product in this category it seems:
Price seems to be $2700
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Good results are being reported for stem cell therapies for skin and frailty:
Skin Trials:
3.2 SC preparations for facial skin aging and photoaging
Skin aging is due to natural causes, as well as extrinsic factors (especially Sun exposure: Photoaging) (Zhang and Duan, 2018; Wong and Chew, 2021). Several SC preparations are investigated for facial skin aging and photoaging (Table 2).
Long-term natural aging is a slow process of dermal atrophy due to elastin and elastic fiber degradation, lower collagen production and lower hydration levels, leading to loss of elasticity and wrinkles (Zhang and Duan, 2018; Wong and Chew, 2021). Clinical trials with MSCs preparations for facial skin aging are evaluating their efficacy in regenerating normal, youthful skin (facial rejuvenation) (Figure 2).
Exposure to ultraviolet (UV) radiation facilitates skin aging (photoaging), characterized by the degradation of collagen and elastin, with deposition of collagen breakdown products and abnormal elastin fibers in the dermis (solar elastosis) (Huang and Chien, 2020). Clinical trials with MSCs preparations are evaluating their efficacy in restoring a normal skin.
3.2.1 Stromal vascular fraction (SVF) for facial skin aging
The “stromal vascular fraction” (SVF) is a preparation of autologous hAD-MSCs obtained by liposuction, followed by collagenase digestion, filtration, centrifugation and separation of the SVF (Coleman, 1994; Varghese and Mosahebi, 2017; Alexander, 2019; Khazaei et al., 2021; Surowiecka and Struzyna, 2022). The SVF represents about 10% of the adipose tissue volume, and is composed of hAD-MSCs, adipocyte progenitors, fibroblasts, endothelial cells, vascular smooth muscle cells, lymphocytes, and a variety of immune cells (T-cells and M2 macrophages). The efficacy and tolerability of SVF-enriched autologous fat grafting is currently being investigated in facial skin aging.
3.2.2.1 NCT02923219
NCT02923219 was an RCT comparing the efficacy of SVF-assisted autologous fat grafting (intervention) versus fat transfer alone (control) for facial volume restoration and improvement of skin quality (Table 2) (Yin et al., 2020). Fifty women (mean age: 35.4 years) participated in the study. At 6 months: 1) Whole face volumes (assessed by 3D scanner and Geomagic software) were significantly higher in the intervention group (77.6%) compared to the control group (56.2%, p < 0.001), 2) wrinkles and texture (assessed by VISIA detector) improved significantly more in the intervention group than in the control group, and 3) graft survival rate was significantly higher in the intervention group than in the control group.
3.2.2.2 NCT03928444
NCT03928444 is an RCT comparing intradermal autologous SVF injection on one side of the face versus saline injection on the other side (Table 2). Fifteen female participants with facial aging (35 years or older) are included in the study and will be followed for 6 months. The primary outcome is the degree of aesthetic improvement using the global aesthetic improvement GAIS 5-point scale (Savoia et al., 2014). The trial was completed, but the results were not posted to ClinicalTrials.gov.
3.2.2.3 RPCEC00000362
RPCEC00000362 is an RCT (single-blind) comparing the efficacy of SVF-enriched fat transfer versus conventional fat transfer (Table 2). Participants with facial aging (30–59 years of age) are included in the study and will be followed for 12 months. Outcomes include clinical evaluation and evolution of furrows and wrinkles. Trial completion date was expected for December 2022.
3.2.2.4 IRCT20141007019432N2
IRCT20141007019432N2 is a single-arm clinical trial, designed to investigate the efficacy of autologous SVF transplantation in reducing facial wrinkles (Table 2). Forty-six (46) participants with facial aging (35–65 years of age and with grade 2 to 4 wrinkle type) were included in the study and will be followed for 6 months. The primary outcome is biometric evaluation (with visioface and skin ultrasound) of the amount and extent of facial wrinkles. The trial completion date was not reported.
3.2.2 Soluble paracrine SC factors (secretome) for facial skin aging
3.2.2.1 NCT05508191
NCT05508191 is a single-blind RCT comparing two methods of AD-MSCs “secretome” administration for facial aging (fractional CO₂ laser treatment on one side of the face and microneedle treatment on the other half) (Table 2; Figure 1). The term “secretome” designates the soluble paracrine factors produced by SCs (Xia et al., 2019). Thirty female participants with facial aging (35–59 years) are included in the study and will be followed for 6 weeks. Primary outcomes are: 1) Skin aging changes evaluated by dermoscopy photoaging scale and by Janus-3Ⓡ skin analyzer, 2) skin capacitance evaluated by the CorneometerⓇ and 3) total water content in the stratum corneum of the skin. Primary completion date was expected for October 2022.
3.2.3 Facial photoaging
3.2.3.1 hBM-MSCs
NCT01771679 is a phase I/II safety trial to evaluate the safety and efficacy of a single intravenous injection of allogeneic (non-hematopoietic) hBM-MSCs for the treatment of facial photoaging in men and women 40–70 years of age (Table 2). Recruitment was suspended.
3.2.3.2 Exosomes
SCs secrete exosomes (40–120 nm extracellular vesicles), which contain cytokines, growth factors, messenger RNAs, and different non-coding RNAs, especially micro-RNAs (mi-RNAs) (Hamdan et al., 2021) (Figure 1).
3.2.3.2.1 ChiCTR2200061216. ChiCTR2200061216 investigates if hAD-MSC derived exosomes loaded with circcol elns (a circular RNA, circRNA) can promote collagen and elastin synthesis in skin samples from 6 to 10 photoaged patients (55–75 years). The study compares samples of facial skin tissue (part exposed to light), with skin tissue of the hip or upper arm (part protected from light) (Table 2). The study is open for recruitment. Completion is expected for December 2024.
3.3 Other SC therapies for aging
3.3.1 NT-020
NT-020 (NutraStem®) is a patented nutraceutical formulation containing green tea extract, blueberry extract, carnosine, and vitamin D3 (EurekAlert, 2008). In 2006, Bickford et al. (2006) reported that these agents (as well as catechin) synergistically stimulated the in vitro proliferation of human bone marrow and human CD34+ and CD133+ cells. CD34+ are often used clinically to quantify H-SC numbers in H-SC transplantation (Remberger et al., 2020). CD133 is a well-characterized biomarker of normal and cancer SCs (Barzegar Behrooz et al., 2019).
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Came across this article recently. It appears that in mouse models, blood donation increases skin thickness, collagen synthesis, and reduces the number of senescent cells:
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There have been a number of members who have touted the benefits of blood donantion (for longevity). Question: is there something about the donation process, or can you remove a proper amount of blood by alternate means — bloodletting at a Rennesaince faire, blood brothers pact, leeches, etc. — and still receive these benefits?
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One of the biggest reasons that I have heard for blood donation is that it helps you purge toxic ‘forever’ chemicals circulating in your blood. Of course you are just giving them to someone else though
I would think replacing your plasma would be more effective. However this is a fringe practice and it is hard to quantify any benefits. I’d stick with the ITP treatments as they have proven bang for the buck.
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