I have been using Radiesse for years. The results are fantastic. It lasts 18 months for me.
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From what I’ve read and you can correct me if I’m wrong, it is a localized treatment. Either as a filler or a more diverse coverage with different dilutions depending on how deep or shallow the injection.
While it certainly appears to be effective for this purpose it’s not going to extend life span as it is not systemic and provides no benefit to the organs that keep you alive.
But I’m going to see if I can get my hands on some of the nano version that is used by the Derms as I would not mind at least looking younger LoL!
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It is localized but I’m sure there can be ways of delivering it to inner parts of the body— not currently available but feasible in principle. Still leaves organs out of the equation.
It works amazingly well. Found me cheap Chinese sources of Radiesse and with dermoelectroporation, it’s my favorite skincare modality by far.
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How is that going for you? Any new before and after pics?
Can you share the details on how you are doing this, perhaps with photos? How deep does this go, and can you control the depth? How do you know it’s “working”? Any side effects? Any pain?
How’s what going? My skincare experiments? I’ve been very busy so keeping it minimalistic. The most effective treatments for me are 1) ultraformer mpt every 4 months and that’s effective to me due to my particular face shape, needing to prevent jowls and keep the jawline snatched 2) Radiesse diluted 1:1 or 1:2 with cytocare or NCFT 135 ha. I have lots of devices that can help with various things but I end up only doing these two. The exception is laser to plump the lips but I’ve been too busy for that lately. They’re looking good enough without the extra help.
I can but probably not till next time I actually do it — hopefully next week. Zero pain, only a weird feeling. But know it’s working on the spot because the product disappears, gets absorbed — maybe not 100% but I’d say around 80%. You cannot control the depth, and that’s a shortcoming but in a sense also a superpower, unless there’s counter-indications for the product going deep, which for Radiesse there aren’t. I actually think this mode of delivery minimizes the risk of nodule formation that you incur with injection because it spreads the product so very thin.
And then the way you know it’s working is by looking in the mirror. It’s unmistakable, but takes a couple of weeks to kick in.
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Is this another device you’ve purchased (if so, which one?) or is it a professional service you get?
For the “Radiesse and with dermoelectroporation” how much do you use in your formulation, and for what areas (square inches?). And Medaura’s related post: Dermoelectroporation for Aging Skin Health
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Please document the steps you take from start to finish so others here can replicate. Tools you use during the process of mixing / diluting, how much you use in ML, for what areas, etc. Sort of like people did with the DIY rapamycin Skin Cream: DIY Rapamycin skin cream
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Can you share sources?
I don’t have the official device — it’s too bulky. But I have essentially the same technology. The important point is to have line vs mere point delivery of energy, otherwise the treatment would take too long and not be that effective. Also important to use the right depths for the right areas. On SCRIBID I found the manual that comes with the official product, specifying all the settings for every facial area, leaving nothing to guess work. I also watched a few webinars on YT by the branded manufacturer so I am very prepared and confident when I work on myself, though ot course it would be much easier to do it to someone else.
Someone else might gravitate towards a different device based on his needs but this happens to be my personal holy grail because I can tell that as I age I’m prone to heaviness in the lower face and it’s perfect for that, to contour it. If you have eye wrinkles or whatnot, something else might work even better. For me this takes care of all my needs.
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Can you share the device you got and source… I’m assuming another Alibaba purchase like the dermoelectroporation device…
There’s this dermatologist on Instagram who showed me how it’s done. All you need is a syringe and a luer lock to dilute it. I use 1.5 cc and aim for every 4 weeks but not indefinitely. Pretty sure after a few treatments spaced apart like that you need to slow down, as I have. Might end up too bulky.
Here he is:
HDR NECK TREATMENT USING DEP (DermoElectroPoration®️)
I’ve always wanted HDR (Hyperdilute Radiesse) treatment of my neck to increase Collagen Type 1 & 3 along with elastin to tighten my loose skin. I can’t really do it myself using a cannula. The DEP (DermoElectroPoration®️) System is my solution.
DEP is the new non-invasive, stand alone powered drug-delivery system.
DermoElectroPoration®️ increases the skin’s permeability by using the skin’s water based channels opened by a particular controlled current delivered to the patient, therefore allowing the substances to be absorbed by the hypodermis and muscle membranes.DermoElectroPoration®️ promotes the transdermal delivery of both micro- and macro molecules (up to 2 million Dalton weight) safely into the body without the use of needles. This is perfect for skin boosters and PRP hair restoration, which typically require upwards of 100 injections. Another popular indication is the delivery of Hyperdilute Radiesse (HDR) for skin biostimulation as seen here.
Treatment results will come to full bloom in 3-4 months. I’ll keep you posted regarding my progress.
And here’s how you dilute it. Stupid simple:
You can even use saline to dilute it but I use Cytocare or NCFT 135 HA as this derm has had better results from it that way. And it stands to reason.
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What is the name of your device that you purchased for this?
Radiesse is a proprietary product made by Merz Aesthetics, and authentic versions are typically not manufactured in China. What you’ll find on Chinese platforms are Radiesse-style fillers—often calcium-based or poly-L-lactic acid alternatives—marketed for similar aesthetic uses. Quality, sterility, and safety standards may vary widely.
About diluting Radiesse - it’s simple only in videos. If done incorrectly the mixture will start foaming (and has to be discarted). Also it’s easy to make a mistake with injection depth. In other words, it’s not for amateurs for sure. It’s a difficult filler to work with.
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I am discussing the DermoElectroPoration here - yes, self injecting is something I would be extremely leery about.
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Ah - that is true for all of Annis Dang’s products… they are all knock-offs.
While for some things the knock-offs might be fine, it’s really hard to tell, or discern “good” from “less good” or “bad” products. Here is a CGPT5 summary of this issue:
AI Summary of Issues with Knockoffs:
This is an excellent, nuanced question — and it touches on pharmaceutical manufacturing quality, biomaterial chemistry, and regulatory oversight.
Let’s unpack it carefully.
1. What Radiesse (by Merz Pharma) Actually Is
Radiesse is a class III medical device made by Merz Aesthetics (Merz Pharma, Germany).
It is composed of:
- 30% calcium hydroxylapatite (CaHA) microspheres — smooth, spherical particles ~25–45 μm in diameter
- 70% aqueous carboxymethylcellulose (CMC) gel carrier
It is non-animal, biocompatible, and biodegradable — the CaHA microspheres provide scaffolding for fibroblast-mediated neocollagenesis, while the gel provides temporary volume.
The product has:
- Stringent particle size control (narrow distribution)
- Surface charge optimization
- Low endotoxin and impurity load
- Sterility assurance via validated gamma sterilization
- Extensive ISO 13485 / EU-MDR / FDA 510(k) quality validation
So although the chemical formula (Ca₁₀(PO₄)₆(OH)₂) looks simple, how it is processed and stabilized in the CMC matrix is highly engineered.
2. Is CaHA “Easy to Replicate”?
Chemically — yes.
Biologically and medically — not remotely.
Basic synthesis
Producing CaHA powder (for lab ceramics or dental bone grafts) is straightforward: mix calcium and phosphate salts under controlled pH, precipitate, dry, and sinter. Many labs in China, India, or Europe can do this cheaply.
But for dermal filler use
You must precisely control:
- Particle size (25–45 μm) and distribution width
- Surface morphology (smooth, non-porous)
- Zeta potential (electrostatic charge affects aggregation and inflammation)
- Purity / residual salts
- Endotoxin levels (<0.5 EU/mL)
- Sterility and pyrogenicity
- Uniform suspension in the CMC gel carrier
These factors require pharmaceutical-grade synthesis, ultrafiltration, cleanroom processing, validated sterilization, and multi-lot biocompatibility testing (ISO 10993).
Those quality controls are the difficult — and expensive — parts. The chemical recipe is public; the reproducible, safe biomaterial is not.
3. Likely Differences with “Knockoffs” or Unapproved Imports
| Parameter | Merz Radiesse | Typical Unregulated Copy (China / gray market) | Clinical Implication |
|---|---|---|---|
| Particle size control | Tight (25–45 μm) | Broad (5–80 μm) | Irregular particles → uneven injection, lumping, granulomas |
| Surface finish | Smooth, uniform | Often rough / porous | Higher macrophage activation, nodules |
| Purity / endotoxin | Pharmaceutical-grade, batch tested | Often unknown | Inflammatory reactions, sterile abscesses |
| CMC carrier stability | Optimized viscosity, resorption profile | May separate or clump | Uneven results, injection resistance |
| Sterility validation | Gamma sterilization, ISO 11137 | Variable / unverified | Infection risk |
| Regulatory oversight | CE mark, FDA 510(k), post-market surveillance | None / fake certificates | No recourse for adverse events |
| Shelf stability | ≥2 years validated | Often untested | Loss of performance, microbial growth |
So while the CaHA chemical formula is simple, replicating the biomaterial quality and sterility of Merz’s product is complex and capital-intensive.
4. Safety and Clinical Consequences of Using Knockoffs
Real-world reports (from dermatology and plastic surgery societies, esp. in Asia and South America) have documented:
- Nodules / granulomas
- Inflammatory reactions
- Skin necrosis from vessel embolization
- Inconsistent degradation
- Poor or short-lived results
This happens because the knockoff products may:
- Have non-uniform microsphere sizes, which can clog microvessels
- Contain residual ionic contaminants
- Use improper gel carriers
- Or be non-sterile (contaminated during manufacturing or repackaging)
Even if some counterfeit CaHA products appear similar visually, their in vivo rheology, tissue response, and resorption can differ drastically.
5. China’s Role in CaHA Production
China has a strong biomaterials industry (for bone grafts, dental ceramics, etc.), so technical capability exists.
However:
- Many domestic CaHA-based “fillers” are approved only under local NMPA (formerly CFDA), not FDA/EMA.
- Some are legitimate Chinese brands (e.g., Biohyalux’s CaHA-based fillers) with real local clinical data.
- But many gray-market “Radiesse-like” products (sold on non-medical websites) are counterfeit, relabeled, or illegally exported.
Even if the manufacturer can technically make CaHA microspheres, replicating the precise Radiesse microstructure and carrier performance requires proprietary process controls and expensive equipment.
6. Expert Summary
Chemically easy, biologically hard, clinically dangerous if unregulated.
- The CaHA molecule itself is not unique, but the particle engineering, purification, and sterile suspension technology in Merz’s product are difficult to duplicate safely.
- Counterfeit or low-cost CaHA fillers may cause serious inflammatory or vascular complications.
- Authentic Radiesse remains the benchmark CaHA filler, backed by >200 clinical publications and 15+ years of safety data.
Bottom Line
- Radiesse (Merz) is a precision-engineered biomaterial, not just “calcium powder in gel.”
- While CaHA synthesis is simple, achieving the same purity, uniformity, and tissue biocompatibility requires Merz-level GMP infrastructure.
- “Knockoffs” are therefore high risk, even if they appear chemically identical.
- For any CaHA-based filler, regulatory approval + traceable supply chain are non-negotiable markers of safety.
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I just can’t imagine buying knockoff anything from China and injecting it into myself, lol. They have every incentive in the world to cut corners and pretty much no incentive to make a good product. If you want Radiesse, why not just use Radiesse?
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I agree, for me the risk/reward trade-off is not worth it. I’d pay the extra money for the real FDA-approved product.
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