How to Reverse Skin Aging (2022 to 2024)

If you are dry skin, you can use hydrophilic moisturizer first, then differin cream, then oily moisturizer, if you are oily or acne skin, directly use differin is better.

Avoid some regions on face, because you will experience pain and dryness on these regions

  • Around eyes
  • Sulcus between Alae of nose and face
  • Around lip, especially around Oral commisures

NEVER rub your skin, ignore any flaking, if you have flaking, just put moisturizer on it, if you rub your skin, you may experience pain for many days! I did that once, that’s really a torture.

Usually I use tretinoin 0.1% on nose, tretinoin 0.05% on face, retinol 1% around eyes and neck, On winter I use less, and on summer I use more.

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The best and easiest way to reverse skin aging and maintain youthful appearance is to do mesotherapy once every 2-3 months. The effect is immediate and long lasting. Mesotherapy is a procedure of injecting small amounts of HA with vitamins superficially into skin (up to 2 mm depth) with distance of 1/4 -inch between injections with needle 32 g (very thin). There are many products available. I tried many of them. My favorite is CytoCare 532. I’m 67 and don’t have wrinkles. My skin (color, tone, absence of any blemishes, etc) is the same as it was 30 years ago.

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In the present study, although mild clinical improvement in skin texture was observed in some study participants (n = 2) after the third session, subjective, as well as objective, quantitative evaluation suggested that mesotherapy treatment utilizing the protocol established in this study has no significant beneficial effect in reversing the signs of skin aging

Just quick search, I don’t know if mesotherapy is really effective, do you have more information about it?

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There are several ways to keep our skin healthy and looking good. Mybe everyone will find the “formula” that works for them! I have been applying a homemade Rapa cream to my face daily for 20 months with good results. I know that rapa does not cross the skin and enter the bloodstream, but as I am evaluating adding Dasatinibe to the “formula”, I do not know if this drug also do not cross and enter in the bloodstream…

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It’s really effective! Don’t have information besides my own experience with it for approx 8 years. I do it regularly (myself) and have wonderful results. It’s very easy to learn how to do it yourself.

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Interesting discussion. Am not ready to self-inject yet. Will try to make DIY cream with hyaluronic powder.

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I picked the adapalene because it was effective and more gentle on the skin. We will see.

If not… thanks to Rapamycin… I will be around for a while to try others. Haha :smile:

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Lara - is this something you do yourself, or go to a dermatologist for?

Hi Eduardo, welcome to the forum.

I like the idea of adding Dasatinib to the skin cream and I think I will do that also in the future. It seems that the excipient/base you use to disolve the medication prior to mixing with the cream would be an important factor. Transcutol does help penetrate the skin, but not to an extreme level. I have read that DSMO has an even stronger effect, so I suspect that if you use DSMO it may have a higher chance of getting into the blood stream.

Interestingly, the molecular weight of Dasatinib is about half that of rapamycin, so the risk may be higher, but I’m not familiar with the pharmacokinetics:

I do it myself - I had a nursing degree 40 years ago so injections are easy for me. I buy CytoCare from a pharmacy in France and inject the product myself. This product is not available in the US unless you are a doctor. Many of my friends though do it without any formal training with great success. There are detailed YouTube videos available to learn. If one starts early and does it regularly, the skin won’t have a chance to get old.

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Just to be clear, the adapalene mentioned in Dr Stanfield’s video is the 0.3%, which is prescription-only (otc is 0.1%) and I’ve only specifically seen the 0.3% studied for skin aging, although there’s every reason to believe the 0.1% should work as well. I use adapalene personally, but I often prescribe tretinoin 0.025% to my patients if they request it. There’s no reason to go stronger unless you have acne or perhaps extensive actinic (sun) damage, IMO.

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It’s not like injecting skin fillers. It’s much safer: the depth is 1-2 mm. The effect is immediate. Skin is getting hydrated and stays hydrated for a long time. No cream application can compete with it. And btw it’s how all celebrities maintain their skin appearance. They promote creams but get real results from mesotherapy. It’s also an excellent treatment for hands, neck and décolleté area.

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I do not doubt the safety. It is more a user problem - my skill.

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This website has user reviews, before and after photos, and cost information (if getting it done professionally) of all kinds of procedures like this:

https://www.realself.com/nonsurgical/mesotherapy

More info:

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What kind of needling product do you use for this?
I’m assuming this is different from the micro needling type of products you can find on amazon, and that people here have mentioned in other threads.

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I use three types of needles (30 g): 2mm ( for vertical injection), 4mm (slight angle), and 13mm - angled injections. I buy needles on Mesoram.

Thanks! Interesting… So this site:

and these needles for the 13mm angled injections? Can’t find the other ones you mentioned. Please provide links to exactly what you buy.

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And you use this product - is that correct?

I used DMSO as a diluent but in the next formulation it will be transcutol.

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Yes, it’s the right site. I bought needles from them last year. At that time they had 2mm, 4mm, 13mm and many other lengths. If you cannot find 4mm needles there, it means they are out of stock. However, a 13 mm needle is great size for all kinds of injections. It’s perfect for meso. Just remember not to inject deeper than 2 mm.

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