I found the website where they sell it. See here:
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Iāve been using their face cream, eye cream, and body lotion for several months now. I love them! I receive positive comments on my skin. I use to use rapamycin cream, but it made me break out with acne. Iād love to try it again at some point, but OneSkin has been a great alternative. I think their products work. Iām going to continue to use them.
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Iāve been using OneSkin on my hands and face (the eye cream, face cream and body lotion) for perhaps three months now. I like the products, and Iām going to continue with them, but I must mention that so far, I havenāt noticed any dramatic changes. I actually went so far as to do a couple ābeforeā photos in my bathroom (which none of you will ever see, since I took them without a speck of makeup on, in a very bright, harsh lightānot flattering!), and I compared them to new photos, taken in the same conditions, about a week ago. Wellā¦Iām not looking any worse (haha), but I canāt say that Iām seeing any improvement, either. I believe the company says itāll take several months to see noteworthy changes, so Iāll let you know what I think in another month or two.
I do want to say that Iāve been reading up on them for quite some time, and I was also in attendance at the longevity summit that our beloved RapAdmin so thoroughly reported on (Thanks, RapAdmin!), and I believe their research is legit.
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Several days ago, I also took some before pictures around my eyes. Iāll apply only OneSkin around one eye and my usual rapamycin cream around the other. I hope to see a difference in a few months.
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Canagliflozin is getting all of the headlines. Maybe because Ivokana Canagliflozin is not available as a generic in the U.S.
Empagliflozin is a generic and might be the better choice for both efficacy and cost.
Empaglifozin is available from India at about a 33% cheaper price than Canaglifozin.
"We found similar reductions in worsening HF with empagliflozin, canagliflozin and dapagliflozin. However, empagliflozin was associated with a greater reduction in all-cause and cardiovascular mortality.
āComparative efficacy of sodium-glucose cotransporter-2 inhibitors (SGLT2i) for cardiovascular outcomes in type 2 diabetes: a systematic review and network meta-analysis of randomised controlled trialsā
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I havenāt tried rapamycin cream, although I know that many of our members are using it. Where are you getting it? Iām down for joining you in your experiment!
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My current recipe for rapamycin skin cream, based on Dr. Greenās recipe, uses any skin cream plus 16mg rapamycin (ground, then the āskinā of the tablet thoroughly removed via a tea strainer) mixed with 100g skin cream +2% transcutol (2g) to increase absorption.
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The most common source I hear of for purchasing rapamycin topical cream is the Healthspan product:
I suspect a protocol that may be beneficial is alternating the rapamycin cream with the OS1 cream - so that you get the collagen growth that the OS1 seems to provide (which rapamycin will not).
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Thanks for sharing this site, RapAdmin! I saw your suggestion for alternating rapa cream with OS1 in your report on the longevity summit (outstanding report, by the way!), and I thought it was a good one. I hadnāt investigated a rapa cream source yet, so thanks again for your assistance.
Thanks for the recipe! Have you been using it for a while? Any pro/con results so far? And I assume youāre simply using āregularā rapamycin pills and grinding them up? RapAdmin just provided a commercial source for rapa cream, as well, which I will also investigate. As soon as Iāve obtained some cream, Iāll join you in an experiment. I think Iāll use the top of my hand for mine, and we can compare notes.
Yes, regular rapa pills ground up. Iāve been using it for about 18 months irregularly until now, so I canāt say I have noticed a difference. Now Iāve started using the two creams around the eyes twice a day.
An article discussing some of these issues:
Meanwhile, other research groups showed last year just how far these embryo models made from stem cells can develop toward whole organisms. Teams led by Magdalena Zernicka-Goetz at the University of Cambridge and by Jacob Hanna at the Weizmann Institute of Science in Rehovot, Israel, both made them from mouse stem cells and grew them in rotating glass bottles filled with nutrients, which acted like a kind of crude artificial uterus. After about eight days, it was possible to make out the central axis that would, in a normal embryo, become a spinal column, along with the bulbous blob of the nascent head and even a primitive beating heart. Youād need to be an expert to distinguish these living entities from real mouse embryos at a comparable developmental stage.
No one is entirely sure what embryo models are ā biologically, ethically or legally ā or what they could ultimately become. They could be immensely useful for research, revealing aspects of our developmental processes previously beyond the reach of experiments. They might someday even be used to provide tissues and miniature organs for surgical transplantation. But they also raise profound ethical and philosophical questions.
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Good news on Fauna Bio, teaming up with Lilly:
Dec. 21, 2023 /PRNewswire/ ā Fauna Bio, a biotechnology company improving human health by leveraging animal genomics, today announced a multi-year agreement with Eli Lilly and Company to apply Faunaās Convergenceā¢ artificial intelligence (AI) platform to support preclinical drug discovery efforts in obesity. The two teams will collaborate to identify multiple drug targets.
Under the terms of the collaboration, Fauna Bio will receive an upfront payment, including an equity investment, and is eligible to receive up to an aggregate $494 million in pre-clinical, clinical and commercial milestone payments, as well as royalties on product sales.
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A short new video from Omri Dory (Founder of Renewal Bio, mentioned above ), and Nathan Cheng and Mark Hamalainenās Longevity Biotech Fellowship, an organization helping entrepreneurs in the longevity biotech market. https://www.longbiofellowship.org
From: omri_drory on twitter: https://twitter.com/omri_drory
Our NFX documentary on longevity goes live today. Excited to share our vision on this major transition from sick care to healthcare, as well as the work of so many great founders, scientists and investors in the space.
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As long as Renewal Bio is talking about regenerating organsā¦ might as well include testicles on the list 
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At least he has the balls to try it. 
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A podcast on the synthetic embryo biology that is the basis for the startup āRenewal Bioā:
NFXBio: The Promise of Synthetic Embryos with Dr. Jacob Hanna of Renewal Bio
Weāre highlighting a breakthrough moment - this summer, Dr. Jacob Hanna, a professor at the Weizmann Institute of Science published a paper demonstrating that synthetic mouse embryos could be grown outside the womb, without an egg or sperm. This is a major advance that was covered by Nature, The Washington Post, The New York Times, and others.
Today, the head of NFXBio Omri Amirav-Drory is sitting down with Dr. Hanna to discuss how we reached this milestone, what it means for science, and how entrepreneurship can help bring this technology out of the lab.
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