Glad I am not the only one. There are those who can walk a narrow beam and those who cannot. In spite of my reasonable athletic abilities, I was never good at balance exercises at any age. I am very poor at balancing with my eye closed. If this is a longevity test, I am long dead.
But, still, I am ticking along pretty well for an 82year old.
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Adopted, my familyās genetics are unknown
Me too. I have wracked my brain on this question. I wonder about all the ascending and descending tracts from Neuroanatomy in Med School. I also had a nasty 30-minute sneezing attack last year, and wonder if I broke something in the process.
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Desertshores: The poor balance has nothing to do with longevity, to my knowledge! It does, however, have to do with a fear of heights-- people with poor proprioception rely more on eyesight for balance, and being way up high throws off the proportions of things, visually. Thatās what 23&me said, anyway. I never had cause to look into it in any depthā¦ but it is interesting!
Great to hear that rapamycin has helped with your joint pain. (And that youāre 82 and going strong!) Thatās a key feature of Ehlers-Danlos (because the joints are so bendy), so I am hoping I might improve as you have.
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DrM: When you have a spare $99, do a 23&me! Itās quite interesting and sometimes can yield relevant information for health.
If you find anything (at whatever point in the future) having to do with the ear, please do post it. Iām thinking I (and you) may have a genetic type that is more sensitive to ototoxic effects. Iām not going to stop, but I will lower my dose and see how it goes.
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I was referring to previous posts by RapAdmin and rivasp12: In any case blind or eyes wide open, I would never have done well on these tests.
Unfortunately, I donāt know whether or not rapamycin at lower dosages reverses or helps arthritis pain. I became pain-free after several weeks of high dosages. The pain has stayed away for well over a year now. Maybe lower doses will also work.
āIn vivo, the rapamycin particles decreased the symptoms of RA in mice, and the production of inflammatory cytokines was associated with the occurrence of RA. The present study partially revealed the interactions between rapamycin and two types of immune cell in RA disease, and may potentially offer a solution to improve the treatment of RA.ā
There are many studies indicating that it should help. Also, metformin is mentioned in some as being synergistic. So, best wishes.
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I just wanted to update the group on my tinnitus and how colchicine has reduced its severity. Within two days of taking colchicine my tinnitus went from a raging pitch to a very slight pitch. It really is amazing. This has lasted for a month now since taking colchicine daily. I read elsewhere on this forum however that there is an interaction between rapamycin and colchicine and now wondering if I should stop taking colchicine on the day before and day of when I take my daily rapamycin. Thoughts?
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Has anyone else had this experience with colchicine? Please post if youāve noticed anything like this. n=1 is a start, but lets see if we can get it higher.
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Just some more info. I did not start the Colchicine for Tinnitus purposesā¦more to reduce inflammation and hence longevity purposesā¦but the indirect tinnitus benefit has been a game changer in terms of my quality of life.
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What was the dose you were taking when you noticed a reduction in tinnitus?
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AWTTW:
While colchicine is an interesting drug, it is not one of the particularly safe ones, especially for the elderly. Colchicine has a low threshold for toxicity and must be used with extreme care. One I think I will skip out an abundance of caution. I can find zero information that it does anything for tinnitus. Maybe the ant-inflammatory effects? Though I canāt believe that is so since I take several anti-inflammatories already.
āColchicine is only indicated for intermittent use and patients will often initiate treatment themselves; therefore the potential exists for a severe drug interaction to occur.ā
āColchicine has a low threshold for toxicity and must be used with extreme care. Colchicine is only indicated for intermittent use and patients will often initiate treatment themselves; therefore the potential exists for a severe drug interaction to occur.ā
āThe lowest effective dose of colchicine should be used and must not exceed 6 mg over four days.
Elderly patients and patients with hepatic or renal impairment are at higher risk of colchicine toxicity.
Colchicine should not be used in patients with hepatic or renal impairment who are also taking CYP3A4 and P-glycoprotein inhibitors.ā
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0.6 mg is the dose I take.