I did not know you can send crypto via PayPal… Good to hear.
J147 was developed 11 years ago, It has been around and available for at least 10 years. It’s a small molecule derivative of curcumin, designed to enhance BBB penetration, oral bioavailability, among other properties.
There is only one Phase 1 study in humans to evaluate safety and it passed that at single oral doses of 900 to 1800mg per dose for 7 days.
All the other studies are in mice. Delivered orally. Since all AD studies in mice have led to zero significant advances in the area of AD, I would not bank too much on J147 being of great benefit in humans for AD. That’s not to say I wouldn’t try it 
Based on the mouse studies a HED would be around 50 - 60 mg per day but as seen above, humans can tolerate a much bigger dose
Not many US mfg’s of peptides other than the drug companies and some research oriented mfg’s that supply Uni’s and other research organizations.
I looked into setting a small one up, but I’m about $800,000 short at the moment
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Thanks for that information. I don’t want to lose my account.
@qBx123Yk This is exactly what I ultimately did.
I had a coin base account, but it kept blocking me from trying to fund it… so then I funded PayPal and bought SOL, and then I sent SOL to Exodus.
Funding coinbase is the part that was taking me so long… said I could move up to $300 over and then it failed… then it said I coudn’t move anything over… etc etc… I gave up and tried PayPal which worked much better.
And then I sent from exodus but I shorted them .40 due to fees… so then I had to do it all over again
@Steve_Combi #gofundme ?
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That sucks. Most vendors will accept the amount stated if sent using stable coins. For example, if you’re sending 100 usdt-sol, the vendor might receive 99.9 or 100.2. Either way, the transaction is considered fully paid.
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Hmmm, maybe I used SOL and not USDT sol? Is that possible? I remember seeing options and I didn’t know what I was doing.
I will note that even after I sent the .40, and after each payment the site showed payment was received, it then showed payment failed and asked me to start over… I didn’t and opened a ticket showing a screen shot of my exodus payments… and then they processed it as paid… this might have happened eventually on their own, but I dunno ?
Basically, nothing went smoothly in this transaction !
Fyi, there was a quick mention of ss-31 in the recent huberman podcast.
It starts at 2:34 and lasts for a couple of minutes…
I’ll share a couple of screen shots of the dialogue…at 2:36, the guest says it has not lived up to the expectations.
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I think it really depends on the “expectation”, it’s not going to benefit people with a normal functioning mitochondrial system, especially younger people. The studies show zero benefit for “young” people
What it hasn’t lived up to is the influencer hype train that is purely driven by money, not fact.
For people with a disrupted mito system it does provide a benefit. As seen with Barths syndrome.
It comes down to fixing something that isn’t broken. It’s not a miracle cure for something that may not exist.
As we age 2 things (and more) are happening with mitochondria, 1) we have less of them, 2) the ones we have left are declining in functionality.
For “elderly” people who do have a degrading mito system, SS 31 may be beneficial to a degree. It helps the remaining mitos’s function better as evidenced by the significant increase of 27% in ATPmax measurements after 1x 40mg dose.
It’s not going to give you more mitochondria, which is another issue, but it appears to help support the remaining, aging (poorly functioning) mitochondria.
At what age would this be of benefit? my guess would be over 50 to notice a difference. Again it depends a lot on the condition of the individual. If fitness is optimized, diet is optimized, and there are no underlying conditions driving mitochondrial health and count down, there would be less noticeable benefit.
In other words you can’t fix what is not broken, if you are already doing the best to support your mito’s.
The real breakthrough will be adding new healthy, functional mito’s back into our system as we age.
As someone over the age of 50 and having experienced a benefit, I’ll keep taking it to provide a bit more support to an already aging mito system.
Also looking into AICAR how can you go wrong with a peptide on the WADA banned compound list
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Didn’t watch the whole of it but says the young guy that has NEVER taken any medication nor any supplements (by his own admission) for longevity. Wouldn’t expect anything different from him. Having said that I also am skeptical about SS-31 (as I am about most peptides in general).
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What about the 7,000 peptides your body makes?
Oh yes, I agree grain of salt with anything either of them say. Huberman won’t take rapa either.
I did take my first baby dose last night… less than 1mg. My skin was red and itchy for an hour… hoping I’m not allergic… I’ll try again today.
Also… on not listening to the entire episode… I think most of it was a waste of time… but I had a long car ride, so…
The guest did say the evidence on Urolithin A was looking pretty good.
Huberman mentioned taking coq10
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Well, I’m sure they are all important but the thing with me is I might make enough on my own because I have literally tried over 25 of them and ONLY a select few (3-4) had a noticeable effect, even that a very small one. I think the placebo effect is real especially for people who are healthy and live an active lifestyle. For someone that goes to the gym daily for an hour or so (as an example), and then they say oh I feel more energy because of a peptide, it is subjective and hard to quantify IMO. Clearly if you spend an hour daily at the gym you must have a lot of energy to start with.
Or same person saying oh I heal faster on a certain peptide, really? how can you tell? If you had a problem healing fast you would not be able to go to gym daily to start with. So, anything with I feel more energy, or I heal faster etc. can’t be taken as real effects, it is so subjective that they should be ignored as placebo IMO. If someone had something more specific such as you lift daily 200lbs (as an example) and all of the sudden you can do 250lbs then that is quantifiable. Actually, that is exactly the case with me doing HGH and HCG regularly. My strength increased by at least 30% and that is very easy to quantify so I know it’s having an effect as an example. Just my opinion based on my personal experience.
Actually, I’d love for peptides to have real effects because I have HUGE stashes of them in a medical freezer, but I was so disappointed by most (mott’c, BPC, TB500 etc., the most common ones that are supposed to make one fly LOL had absolutely ZERO noticeable effect) so I stopped using them all. The only one that I thought I felt something (small but noticeable) was Oxytocin and might continue using it again. The other one was Pt-141 clearly had an effect, but that is only for sexual activity and NOT a good idea to even use if you’re not anticipating some game in next hour or so lol. Melonatan 2 does tan your skin, but the tanning looks ugly/unnatural in my opinion.
Obviously, other people experiences might be different.
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Keep us posted especially after you’ve done the bigger dose for a week or so. While I have my doubts about peptides, SS-31 is FDA approved and that should count for something.
How did you “take” it? oral/sublinqual or other?
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It’s interesting… the devil is in the details. The company had a tough time getting it through the FDA, taking three efforts before it passed. That said, the treatment was for Barth Syndrome, of which there are something like 200 people diagnosed in the USA with the disease, and its frequency extremely debilitating, many dying before age 40 etc. So in talking with Hazel Szeto she suggested that because you have such a small pool or potential clinical trial participants you have to take what you get, many are very ill, very different ages (young children to “old” 40 year olds, etc. So it’s a very difficult population to do a clinical trial in. And, not exactly a very representative population from the broader indication of “aging” and age-related mitochondrial disfunction.
Like with many drugs and therapeutics in the longevity field… you really need to dig into the details to understand the clinical trial, or results, and not at all easy to understand even for experts not familiar with clinical trial design, and implementation.
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I took it sub q injection
I just gave myself my second shot with an ever so slightly larger dose, and same thing… red and itchy. The itchiness subsided in about 10 minutes but it’s still a little red.
So - its red and itchy arround the injection site? Does this typically happen with peptide injections, or is this something new?
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No, it is not common with peptide injections. There is however a few of them that have such effect. Of the ones I’ve tried (about 30) only one had such effect. I think it was GHK-CU or something…and one of them burnt a bit (no itch or redness) and if I’m not mistaken that one was MOTc. Sorry don’t recall them that easy cause I was surprised for the worst (by peptides) so I didn’t even pay much attention and stopped them all (after three months trying them and having no effect), except a couple I felt were having positive effects.
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It’s pretty common to have a mild ISR (injection site reaction), especially for some peptides vs others. SS-31, tesamorelin, mots-C for instance are fairly routine offenders. It’s not a bad idea to have a couple of epi-pens in the house just in the rare event that anaphylaxis occurs. Of course, anaphylaxis can also occur from any number of other medications, allergies, bee stings, etc so IMO it might not be a bad idea for anyone/everyone to have an epi-pen if there were enough to go around and affordability weren’t an issue.
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