Hair loss or regrowth using Rapamycin or Metformin, or Melatonin?

[EduardoLeon]

Hi folks! First day on here. I wanted to discuss with any of you in regards to any potential hair loss and/or hair regrowth from using any of the two drugs, primarily rapamycin. Thank you!

Kind regards, Eduardo

[RapAdmin]

I have not heard of hair regrowth from metformin but there is research to suggest that topical rapamycin cream/serum regularly rubbed into the scalp may help with hair regrowth and color (see link below).

Also, a few people have posted in the thread below about trying it, and their results.

See this link:

Rapamycin for Hair Growth and Pigmentation: mTORC1 activity controls human scalp hair follicle pigmentation and growth

This is a research paper from earlier this year that hasn’t gotten much attention. It seems like people may want to try topical rapamycin as a way to encourage hair regrowth and repigmentation. Our preliminary data suggest that Rapamycin treatment can even partially restimulate pigmentation in some greying scalp HFs ex vivo . In contrast, TSC2 silencing ex vivo induced hyperactivation of mTORC1 and reduced human scalp HF melanogenesis. In summary, we provide the first evidence that mTOR activity is an important, previously unappreciated physiological regulator of human hair growth and pigmentation. Thus, inhibiting intrafollicular mTORC1 activity by Rapa and rapalogs may become an attractive novel intervention strategy in the future management of greying, and alopecia. Full Researc…

[RapAdmin]

Other papers on rapamycin and mTOR and hair growth:

Stimulation of Hair Growth by Small Molecules that Activate Autophagy (full paper below)
https://www.cell.com/cell-reports/pdf/S2211-1247(19)30699-0.pdf

and another:

deng2015.pdf (701.9 KB)

[JuanDaw]

Study mentioned alpha-ketoglutarate before metformin.

Hair grew from the pigmented skin area of a-KG-treated mice within 5–7 days, and by day 39 post-treatment, a-KG-treated mice exhibited robust hair growth; in contrast, control mice showed little or no hair growth overall.

Can’t find the formula for the topical AKG in the paper. Will need to poke around for other studies. Metformin looks promising though, based on your other post, with pics of two women, pre and post topical metformin. Proportions were also provided (ten percent metformin).

[JuanDaw]

Full article on AKG and hair growth.

Hair regeneration by small molecules that activate autophagy

303495.full.pdf

[JuanDaw]

Looks like fisetin also induces hair growth.

Fisetin Promotes Hair Growth by Augmenting TERT Expression

[RapAdmin]

Why is everyone talking about rosemary oil for hair when there is more research on melatonin for hair growth? Dermatologist @DrDrayzday on topical melatonin for hair growth.

THIS BEATS ROSEMARY OIL FOR HAIR GROWTH 😱

[RapAdmin]

I guess we can also try tretinoin gel (wouldn’t want the cream in my hair):

Bazzano GS, Terezakis N, Galen W. Topical tretinoin for hair growth promotion. J Am Acad Dermatol. 1986 Oct;15(4 Pt 2):880-3, 890-3. doi: 10.1016/s0190-9622(86)80024-x. PMID: 3771854.

Bergfeld WF. Retinoids and hair growth. J Am Acad Dermatol. 1998 Aug;39(2 Pt 3):S86-9. doi: 10.1016/s0190-9622(98)70452-9. PMID: 9703131.

Vestita M, Giudice G, Bonamonte D, Apruzzi D, Filoni A. Beard hair density increase. A possible role of topical tretinoin application? Dermatol Ther. 2017 May;30(3). doi: 10.1111/dth.12450. Epub 2016 Nov 25. PMID: 27886445.

CAN TRETINOIN GROW YOUR HAIR? 🤔 Dermatologist @DrDrayzday

I notice that in the Indian online Pharmacies they have tretinoin gel, which may work for scalp applications (without the residue and color of the white tretinoin / Retin A cream that is the typical formulation). 83 rupees to the US$ approximately.