Many of us here are concerned about dementia. I think your thoughts (anabolic vs catabolic) are interesting and worth thinking about. I’m not sure rapamycin fits into one model or the other though. Many on this group take rapa primarily to prevent dementia, most commonly alzheimers. The proposed mechanism of alzheimers being inflammatory breakdown of the blood brain barrier and rapa proposed to subvert this process through various pathways. Some of this is nicely substantiated in animal models of Alzheimers though most animal models of this disease are poor approximations of the human condition. There are clinical trials underway to study the affect of rapamycin on alzheimers development in humans.
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