Finasteride delays atherosclerosis progression in mice and is associated with a reduction in plasma cholesterol in men

#45

I am pumped to try rapamycin. I’m very cautious about finasteride. I feel like there are benefits to DHT, and from what I’ve heard the 5AR enzyme doesn’t just work on testosterone but works on other hormones.

I’m lucky that testosterone doesn’t affect my hair in a negative way.

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#46

DHT is only marginally used in the body and at least finasteride doesn’t impact the kind of 5ar enzyme that may actually have a role in humans.
ITP male mice also seem to be living longer when given mega-doses of 17a-estradiol despite there definitely being siginficant 5ar inhibition going on at such concentrations.

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#47

It seems 17a-estradiol should be put head to head with finasteride and dutasteride in some studies.

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#48

For BPH is the prescribed 5mg necessary or would a lower dose still work?

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#49

Honestly I don’t know but if you look at the hair retention studies, it’s seems like you can get away with lower dosing of 0.25 mg of finasteride.

Personally and anecdotally I can tell you that dutasteride 0.5 QD works way better for me than finasteride 1 mg with significant reduction in hesitation and increased stream flow. In fact over the years I seemed to forgot what it was like to take a piss as a young man until after few weeks of dutasteride.

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#50

Definitely increase hair growth and thickness. It won’t cure genetic male pattern baldness, but it will definitely allow you to keep your hair longer.

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#51

Any effect on mood or libido? It has such a long half-life that it seems like quite a gamble…

#52

I can tell you that my mood on dutasteride is a lot better than my mood on finasteride. Finasteride gave me mild depression! Dutasteride does nothing to my mood that I can tell. Maybe it blunts a little of my normal joie de vivre, but I’m guessing here. At least it doesn’t cause depression!

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#53

No apparent effects as far as I can tell.

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#54

I have taken 1 mg of finasteride for the last 15 years. If your live in the US and have a Sam’s Plus membership it is $3 per month. 5mg is less expensive.

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#55

I have taken for 34 years at 5mg daily

.Despite higher Cholesterol numbers. In blood tests… … zero Coronary Calcium Scans scores… 3 times… and CT scan of entire chest. Nothing.

Maybe all that finasteride for decades. :laughing:

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#56

90 1mg tablets for $7.47 at Mark Cuban Cost Plus Drugs

https://www.costplusdrugs.com/medications/finasteride-1mg-tablet/

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#57

You should definitely get a CT angiogram with CLEERLY. If only for a peace of mind.

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#58

I’m really on the fence with this one. My DHT level is a bit elevated from testosterone.

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#59

You ever tried Dutasteride or Finasteride?

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#60

If you’re asking me, the answer is no. I am considering one of them though…not sure which one yet. It would be the lowest dose possible probably

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#61

Thanks. Yeah, I was asking you. A bit surprised you have never tried any of them before.
Could always try a cycle (30-60 days) of each (finasteride and dutasteride) to see which one you like more.

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#62

To be honest, the post finasteride syndrome “boogeyman” kind of gave me pause. I have also never had any hair problems, fortunately. It might be useful for me to lower my DHT levels a little bit though.

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#63

Can’t TRT by itself cause ED and prolonged fertility issues?

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#64

Fertility issues yes (though mostly reversible). I would say no the ED though.

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