I meant to post this earlier, regarding ivabradine and afib risk. Sounds like diltiazem might be the better option for HR reduction from a GLP, but I’d like to see some data (even anecdotal) that it actually works.
Question: What is the absolute risk of atrial fibrillation from ivabradine?
Absolute Risk of Atrial Fibrillation from Oral Ivabradine
FDA Drug Label Information
According to the official FDA Drug Label, ivabradine increases the risk of atrial fibrillation. The following data is provided:
Study
Ivabradine Group
Placebo Group
SHIFT
5.0% per patient-year
3.9% per patient-year
Key Points from FDA Label:
Regular cardiac rhythm monitoring is recommended
Discontinue ivabradine if atrial fibrillation develops
Additional Research Findings
Meta-analysis Results
A meta-analysis of randomized controlled trials involving over 40,000 patients found:
Number needed to harm: 208 (95% CI: 122 to 667) per year of treatment (24951486)
Risk Factors and Considerations
Bradycardia, which occurs more frequently with ivabradine, may increase the risk of QT prolongation
This could potentially lead to severe ventricular arrhythmias, including torsade de pointes
Patients with risk factors such as use of QTc prolonging drugs may be at higher risk
Conclusion
The absolute risk of atrial fibrillation from oral ivabradine is approximately 5% per patient-year, which is about 1.1% higher than the risk in patients not taking the medication. While this increase is statistically significant, the absolute risk difference is relatively small. Healthcare providers should weigh the potential benefits of ivabradine against this increased risk of atrial fibrillation, particularly in patients with existing risk factors for arrhythmias.
[Answer generated by www.DrOracle.ai]
I definitely have not experienced this from Retatrutide. I swear people on Reddit read someone else’s experience and then convince themselves they have it too.
FWIW, there is apparently evidence that GLP-1 inhibitors cause people to lose muscle mass as well as fat. It is probably a good idea to combine it with resistance training.
Can’t access Twitter, but I’m guessing he wants to lose more weight? Twitter not allowing people that are not logged in to see content is just hostile, BTW.
FWIW: N=1
I am very impressed with Tirzepatide.
I am using it to eliminate a small amount of remaining external and visceral belly fat.
After only 1 week, I noticed a decrease in appetite. After 2 weeks, I had a noticeable decrease in appetite, and when I am hungry, I am satiated quickly. I rarely clean my plate.
My goal is to maintain a BMI of ~22 +/- .5 while increasing muscle mass. At the same time, I am reducing fat. Presently, I have a BMI of ~22, and I weigh myself every few days and adjust my calorie intake up or down depending on my scale reading.
I inject Tirzepatide directly into the belly fat I am trying to get rid of. After only 2 weeks, there is a noticeable reduction.
There have been zero side effects, and I plan on taking Tirzepatide indefinitely.
So, many peptides, so little time.
I chose Tirzepatide based on a bit of research:
“Tirzepatide is a dual agonist that targets both the glucose-dependent insulinotropic polypeptide (GIP) and GLP-1 receptors. This dual action is unique compared to traditional GLP-1 RAs, which only target the GLP-1 receptor. The GIP receptor activation by tirzepatide enhances insulin secretion and has additional effects on reducing food intake and body weight, although the exact mechanisms in humans are still being studied.[1-3]
Efficacy: Tirzepatide has shown superior efficacy in glycemic control and weight loss compared to traditional GLP-1 RAs. In the SURPASS clinical trials, tirzepatide reduced HbA1c by 1.24% to 2.58% and body weight by 5.4 to 11.7 kg, which are unprecedented results for a single agent. A significant proportion of patients achieved normoglycemia and substantial weight loss.[1][4-5] Tirzepatide was more effective than semaglutide, a leading GLP-1 RA, in reducing both HbA1c and body weight.[1][5]”
“A thorough review of the studies that led to tirzepatide’s approval allows for comparisons between tirzepatide and GLP-1 RAs; it also allows for predictions of tirzepatide’s eventual place in therapy - an agent used preferentially over GLP-1 RAs in patients with or without diabetes desiring to lose weight.”
Been on the Retatrutide for almost five weeks. I keep modifying the dose but have used about an average of 2.5mg per week. I love this stuff. I wasn’t even trying to burn fat and it still fell off. I bloat less from cheat meals and still wake up lean the next day. Strength is as high as ever. My face even looks thinner. I’m a believer
I got mine from Steve Combi. He was offering a special price for Rapamycin News forum members. I don’t know if he is still offering this. DM steve combi @Steve_Combi
you can also get it from peptide suppliers like:
Rt is my personal go to… I have found it to have fewer side effects and I feel “normal” compared to Tz. Now Tz is also ver effective and over time people do acclimate to it and find their normal with it as well.
After 17 months (8m Tz, 9m Rt) I could not be happier with my weight and the peace of mind that brings.
Quite so. I do feel normal on both 21 months into using these. I think I’ve landed on using reta for cuts and tirz for maintenance, one reason being that I get hyperesthesia on reta so I don’t like being on it for too long. The other is that tirz is cheaper per mg and I need less of it to get appetite suppression. Even on 12 mg of reta it’s hard to maintain a deficit of more than 15% while doing daily cardio and weights, but I know I’m an outlier.
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