I just took the skinny pic a few minutes ago in my office so it would be as current as possible.
My 20 minute x 3 day workouts are going well, weights are going up at a moderate pace and my time on the Proform HIIT machine is increasing with additional resistance. Yesterday I breezed through my setting and will be adding some time and resistance to that. I’ve always hated “aerobic” but yesterday it was like nothing. I’ve never experienced that in my life.
Through my 20’s and 30’ and into my 40’s I worked out as heavy as I could, did some aerobics and am pretty strong. My DNA test indicates I have the strength gene but not the size gene and that explained a lot about why i could out lift most of the bigger guys at the gym but never got “big” no matter what I did.
And yes, I’ve done more reading on this topic over the years than I can remember. And tried pretty much anything to get big other than PEDs.
There is a peptide/bio thread with most of it. I can outline my peptide adventures a bit later and may put that in my introduction thread with my other interventions.
Is it recommended to fast while on GLP-1’s or is that a big no. Asking because it seems easy because of appetite suppression, so might as well stay couple days without food also (unless not recommended for medical reasons)?
That is a good question. I think any answer to that one would be a bit speculative. So I’ll speculate
As GLP1’s stabilizes blood sugar levels (blood glucose homeostasis) it may make fasting more “comfortable” and with the appetite suppression, more “endurable”.
I personally would not fast for longer than 24 hr without water but if one were to fast with adequate water/hydration, I’d speculate that would be OK.
If the fast is intended to be for weight loss, I would not bother with fasting. With GLP1’s weight loss can be very steady and predictable once settled into the routine. With that process leading to the goal of ideal weight maintenance and potentially a lower maintenance dose.
If the fast was for other reasons, fasting occasionally could be a reasonable addition to a healthy routine that includes GLP1’s. But I do not have any clinical info regarding this and have not done any searching to see.
This issue has been raised in the thread on Longo’s fast-mimicking -diet. It’s a 5-days very low-calories, low protein, vegan stint. Conceptually, it may be harmful. Pra tically it may be not. There are no studies on it apparently.
Edit: While re-reading my question, it appears that a low-carb version of the FMD might avoid to overstimulate insulin secretion, especially if simple carbs/sudden peaks are avoided.
In Water only, short fasts, there would be no glucose input hence no stimulus to insulin secretion hence no amplification of a glucose signal which is not there.
Anyone notice an increased heart rate on these medications? How significant is the increase? I know there was a little discussion earlier in the thread but not much.
Yes, they have a direct effect on the SA node of the heart. For some it’s just a few extra BPM, but for me it’s like 10. My Oura Ring thinks I’m constantly overtraining/under-rested because of it.
For me not enough to notice. I’m usually 54-60 rested, and last 10 days in RT my rested rate has not gone over 60, though it hasn’t been under 58 either, so maybe 2–3-point difference. I did however notice a change based on monophases for some reason, about 5 rate difference. I have no clue how that can be, or if there is something else that might affect it but haven’t been able to pinpoint. As weird as it sounds, I tend to have better and deeper sleep when a full moon also. Go figure, welcome to our universe. LOL
I don’t really have much fat to lose, but I think I’m going to microdose Retatrutide soon to suppress my appetite a bit and maybe get other benefits. I’m thinking I’ll start at 0.5mg per week and try not to go above 1mg per week.
I’m going to go slow and base it off how I feel, so I’m not sure what dose I will eventually land on. I don’t want to kill my appetite but if I can lose the desire to snack, that would be nice.
I started Retatrutide about 10 days ago at 2.5 mg per week and first week the suppression of appetite was pretty significant. I just ate for sake of eating but wasn’t hungry much. On second week then the appetite returned but maybe at 70% of normal. What I find helpful is the fact that I don’t have any cravings for certain foods which I used to. I lost first week about 2lbs, but second week is almost over, and I haven’t lost much could end up being 0.75lb. After few weeks at 2.5mg I plan to go 1mg for a while and perhaps continue 0.50-0.75mg for a long time. BTW, I haven’t noticed any side effects at all.
If you don’t need to lose much, I would do 1mg and then adjust based on how you feel and what you are trying to achieve. Seems pretty potent as 2,5mg I’m doing is definitely suppressing my appetite. I decided to start with 2.5 as I need to shed at least 20, but I’d be happier with 30. It will be a slow journey, but I feel I’ll get there.
Ditto for me, presently I’m finding that 1000 mg of berberine does have this effect, some days pretty pronounced, other days milder. I love the feeling of rising above the desire for food. Letting discrimination govern, not some neurological signal coming from the GI or the hypothalamus.
My biggest health concern is my overweight status. I need to lose 20 lbs to get to my ideal weight. I’ve been losing weight slowly, but I think I need to add Retatrutide to get down to the level I want. Then I’ll cut back to maintain. Thank goodness for GLP-1s. They really make losing weight quite easy.
Just took my first 0.5mg dose of Retatrutide this morning. Hoping for appetite suppression and a bit of a body recomposition effect. I think I will dose 0.5mg every two or three days depending on how I feel. I’m kind of excited about this.
I can just increase the dose until I get a little bit of the appetite suppression then. I don’t want to completely eliminate it, so I’m gonna wing it and see how it goes.