DrugAge: The Database of Ageing-related Drugs

#1

I’m only discovering DrugAge today even though it’s been around for a while, it’s a fantastic website: DrugAge: Database of Ageing-Related Drugs

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#2
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#3

This is where I found Indolepropionamide.

I made a list of other promising compounds I saw at the top of DrugAge. I noted which ones are available immediately for testing on Ora Biomedical C Elegans lifespan studies, and which ones have already been done. All of the rest would need to be purchased at an additional cost before running a lifespan test.

–MEDIAN LIFSPAN–

  • Lithocholic acid - in Ora Biomedical
  • Thioflavin T
  • Bacitracin
  • Acetaminophen - in Ora Biomedical
  • Minocycline - sponsored
  • Selenomethionine - in Ora Biomedical
  • Sorbitol - in Ora Biomedical
  • Trimethadione
  • 2-deoxy-D-glucose - in Ora Biomedical
  • Dimethyl formamide
  • Baicalein - in Ora Biomedical, already tested. Not impressive.
  • Ciclopirox olamine - in Ora Biomedical

–MAX LIFESPAN–

  • L-Carnitine
  • Spermidine - in Ora Biomedical. (Spermadine Trichoride tested, not impressive. Spermadine Tetrachloride form and just “Spermadine” are also available to test)
  • Bis(1-hydroxy-2,2,6,6-tetramethyl-4-piperidinyl)-decandioate
#4

Thanks - this is a great resource. It should probably be pinned.

I’ve just finished a 6 month stint on rapa, and I’m breaking for the winter flu season (southern hemisphere). Looking at the the DrugAge database makes me think that maybe I’m being too cautious; given how consistently rapa has produce statistically significant increases in average and maximum lifespan.

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#5

You need to track your biomarkers while on rapa (or any drug/ntervention). If you see things moving in the right direction, great, if not, course correct. That which is measured, can be affected. Look for optimal values in blood work and see how rapa affects them. It’s an imperfect proxy, but it’s the best we have atm.

#6

Yeah, Im waiting on a blood test. I’d always planned a 6 month stint, test, then re-evaluate. I have plenty of blood test prior to starting to compare to.

#7

Most compounds in the DrugAge db surprisingly increase lifespan. High selection bias. And studies are rarely replicated. So take it with a pinch of salt…

#8

Have a lot at the top of the DrugAge database lifespan extension results. Very interesting!

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