As a principle i aim for the same arm. Normally it has completely repaired during the week.
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I thought i would provide a photo. I last had blood drawn on wednesday. I think one reason injuries repair more slowly in older people is a shortage of cytosolic acetyl-coa. As people know i supplement to increase acetyl-coa levels.
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I think it might depend on the nurse’s skill or luck as well. One time my arm was a mess at the blood drawn spot and it kind of hurt a little bit IIRC, was pretty dark.
That’s true. There are some dreadful phlebotomists. However, I have had blood taken from this spot on these dates (as well as earlier ones): 13/07/2023 19/07/2023 28/07/2023 03/08/2023 10/08/2023 16/08/2023 06/09/2023 12/09/2023 12/09/2023 21/09/2023 27/09/2023
If people wish to experiment with speeding up repair to injury I am happy to talk about that. It is the same citrate protocol as I use for improving differentiation.
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What exactly is your supplementation protocol in this area?
There are two routes towards increasing acetyl-CoA (outside the mitochondria). One involves increasing citrate and the ACLY enzyme them converts that to acetyl-CoA. The other involves increasing acetate and the ACCS2 enzyme converts that to acetyl-CoA. The latter has an element of self-inhibition which is a nuisance.
You can increase citrate in a number of ways. In my view the best thing to do is to eat it, but there are complications that I go into on this thread:
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Another point people may find interesting is that you can increase acetate by either drinking vinegar (I don’t think that is good myself because of the acid) or in fact by drinking alcohol and waiting for the liver to turn the acetaldehyde into acetate. You actually end up with a reasonably high concentration of serum acetate.
However, I think citrate is a better target. It is not necessarily as much fun, however.
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The researchers used data gathered for the Singapore Chinese Health Study, in which 63,257 Chinese people aged 45-74 were followed from 1993 to 2010.
When there were only low amounts of ALA in their blood, EPA and DHA reduced the chance of a heart attack by 18 percent, according to the figure above. At a high ALA concentration, the reduction was as high as 49 percent.
Source publication.
https://www.sciencedirect.com/science/article/pii/S0022316622089969?via%3Dihub
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I am tracking the repair process from venepuncture over the first day and subsequent days for the blood test I did at 1pm today. Would you like me to post results?
Did you ever directly answer this question?
This thread answers the question.
I would also add, that it is quite common for omega-3 supplements to be rancid (over 45% of omega 3 supplements).
That’s of course, not considering that many omega-3 supplements are also not IFOS-certified for toxins and overall purity.
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Paper on omega-3 consumption decreasing epigenetic age as gauged by second-generation epigenetic clocks.
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John, does apple cider vinegar increase acetyl coa? And do you know the dose response curve given the self-inhibition?
Great study, thank you for posting. 49% reduction is enormous.
Worth noting that ezetimibe lowers ala absorption (and maybe dha and EPA too). So worth people upping intake in diet.
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I would think vinegar (whether from apples or malt) has the ability to increase acetyl-CoA. However, I would be concerned about the fact that it is acidic and there is a question as to how much acid the body can tolerate.
Thanks John, This looks interesting: 29ml of vinegar to boost total time to exhaustion in cyclists.
They found an increase but failed to achieve significance given the limitations of the study.
Given my “smorgasbord approach” to things what else could i add to my acetyl coa foods:
apple cider vinegar, * Oranges
- Lemons
- Limes
- Pomegranates
- Grapefruit
- Tangerine
- Passion fruit
- Magnesium citrate supplement (low dose)
Is there anything else i could do without resorting to supplements?
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The increase seems minimal, between water and vinegar. Sugar reduces performance, and nullifies the effect of vinegar.
| Variable | Water | Sugar | Vinegar | SUG + VIN Combination (CBO) | p-Value |
|---|---|---|---|---|---|
| (H2O) | (SUG) | (VIN) | |||
| Total Time to Exhaustion (secs) | 147 ± 8 | 136 ± 7 | 152 ± 7 | 144 ± 7 | 0.25 |
| Heart Rate (bpm) | 169 ± 2 | 170 ± 2 | 168 ± 2 | 171 ± 2 | 0.11 |
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Yes true, but even a small boost to mitochondrial function (if that’s what this is) would be good if it comes at zero risk. We lose about 8% function per decade. So this would equate to about 4.5 years!
I enjoy cider vinegar already as part my normal food and drink, so if upping it slightly can improve my mitochondria it seems worth it. Especially if i can combine with other acetyl coa boosters
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I would be careful with too much acid. Supplements IMO are better as you can control more variables.
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