Does Rapamycin lower eGFR?

[Jonas]

@Tim

I’ve had CKD for five years, with a GFR of 16 at its lowest point. I was advised to prepare for dialysis, which I refused to even consider. I went vegetarian and avoided alcohol, and my GFR jumped to 24 and then to 29. Since then, I’ve taken Rapa, AKG, and Spermidine, and my GFR is now 43. With a study of n=1, I can’t prove cause and effect, but the regimen certainly isn’t hurting. The key is to take low doses of Rapa, not immunosuppressant levels.

Congrats for your kidney success, what dose of rapamycin were you using when you said “low doses”?

[Tim]

@Jonas, I take five mg per week, all in a single dose.

[desertshores]

“Does Rapamycin lower eGFR?”*
N=1 of course, but rapamycin over a 22-month span seems to have either had no effect or increased my eGFR. The reason I can’t say for sure is because as a member of this forum I, of course, have been inspired to add other probable life-extending supplements.
My latest blood tests are all now in the normal range and most are improving including eGFR.

[John_Hemming]

eGFR is calculated from either Creatinine or Cystatin-C or a mixture of the two. Creatinine is really vulnerable to things like exercise and time between sample and test. Cystatin-C also has issues according to a nephrologist friend of mine.

However, getting Kidneys to work better has to be a key healthspan target.

[Tim]

@Paul, How did your GFR go from 40 to 80? Any special diet or medication? Thanks.

[Tim]

Not casting shade here, @desertshores, but it’s easier to go from 70 to 90 than from 30 to 50, say, or even 30 to 40, which is roughly equivalent to the size of your improvement. Still, your numbers are impressive. They mean you are doing many things right, augmented by the supplements.

[John_Hemming]

CKD is about kidney cells not functioning. Quite a bit of that is about senescence and scarring.

Cellular Senescence in the Kidney

Hence reversing that (which is part of age relating diseases) would help.

[Paul]

Clearly was directly related to starting rapamycin. Had been low for over 5 years prior to starting it and has staying high since

[desertshores]

Not bragging about it. Merely publishing an n=1 result of using rapamycin.