Do ARBs increase cancer risk?

#22

Alright, I also want to apologize — if anything I said came across as offensive, please forgive me. That was not my intention.

#23

Thanks. No worries at all. I also apologize if anything I said came as offensive: it wasn’t my goal either. Anyway the evidence we have so far:

Anything else to add to the above @Cole? We should then be able to conclude on the topic based on the available evidence.

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#24

MR analyses demonstrated causal protective effects of genetically proxied ACEI/ARB use on gastric [odds ratio (OR) =0.834, P<0.001], colorectal (OR =0.900, P=0.006), lung (OR =0.928, P=0.02), breast (OR =0.942, P=0.03), and endometrial cancer (OR =0.900, P=0.006). These causal associations remained consistent in validation and sensitivity analyses. Mediation analyses indicated the causal, protective effects were partially mediated by vascular endothelial growth factor A (VEGF-A), total cholesterol, triglycerides, low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C).

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#25

Losartan has been specifically marketed as an ARB that “Treats hypertension and protects kidneys in diabetes” and does so “without inducing the cough that ACEs typically cause in heart failure patients.”

Am I correct to conclude that my grandmother, 89 1/2, with heart failure and otherwise healthy, no diabetes, should consider switching from Losartan to an ACE?

Years of Coreg landed her in rehab after a fall the morning after an outpatient angioplasty procedure in her right leg. After stopping, 6.25mg of Coreg 3X daily, her leg swelling in both legs has diminished but her leg strength hasn’t yet returned. She has no dementia nor Alzheimer’s and longs to return home! She has lived alone since 2018 with zero issues.
On a side note- beware of Coreg- it turned her legs to tree trunks and made her too weak to function independently. It took 8 years- but it finally won. Within 2 days of stopping Corey her legs returned to normal color, no more oozing which had begun several months ago, and each leg had lost over 2” in diameter at the ankles. She was not taking furosemide, so even though the reduction in fluid volume was the reason for the decrease in swelling- simply stopping the Coreg is what allowed her body to naturally rid itself of the fluid- and at a rapid rate!
The sad thing is she has always had a Cardiologist- and any other “specialist” where traditional medicine lead. She is of the generation that believes the healthiest thing to do is whatever the doctor says to do and she does. But the doctors decided when she made it to 80 that healthy for her was “alive” and quality of life irrelevant.
Does anyone know whether Losartan (ARB) can cause weakness in elderly heart failure patients? That is the immediate hurdle to her return home. That, and the weight she gained while on Coreg, which made her increasingly unable to exercise.
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