do you think I could mix the liquid Rapa in to a carrier lotion and that would work? As mentioned the Rapa I use is a liquid- so Im wondering if I just use drops of the liquid Rapa. in some basic neutral face lotion …
or maybe I could just literally use the liquid Rapa. on my face as it is- and my reasons are wrinkles / creepy skin
Here is a little short vid about the rapa lotion. You can also go on Youtube and search rapamycin or sirolimus and get LOTS of good info about what it does for the skin. Have fun!
Hey Lisa, i just went up to your original post when you explained that your dr.prescribed the liquid rapa because you dont take pills well. It just dawned on me! Is the stuff your dr. prescibed supposed to be taken orally? Someone else should really step in here ( @RapAdmin ?) as i dont know enough to tell you correctly but i dont know if you can mix an oral liquid rapa prescription with a lotion to put on your skin. I am wondering if those are two different animals.
That’s a good question. @Lisa can you post a link to the type of rapamycin liquid you are using. I’ve not looked into liquid rapamycin formulations because they are not often used, but they must have some sort of mechanism to “protect” the rapamycin as it goes through the stomach acid, and that could prevent absorption though the skin also. Its something you would need to research a bit.
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Transcutol, otherwise known as diethylene glycol monoethyl ether, is commonly used in the skin care and pharmaceutical industry to both dissolve molecules (so it acts as a solvent for the rapa) and is also a penetration enhancer (helps the rapa penetrate the skin).
DMSO would also do the trick but isn’t as “friendly”…feels very oily and the sulfur in it often results in a garlicky taste in one’s mouth (and even garlic breath) after using it.
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SURE here it is : Sirolimus (oral route) - Mayo Clinic.
I now take 2 ml a week - I bumped it down due to drowsiness but also good point about putting it on the skin since it may have some buffering agent in there- or some thing. The liquid itself is DISGUSTING thick and rather oily like the insides of an omega 3 capsule
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Oh my gosh guys! I made up some rapa lotion and began using it on my hands, lower arms and face on 3/10/25. Today is 3/20/25 and so far the biggest noticeable change is on a barnacle (ya, I know, what an awful name for something growing on you, lol) I have on my face right up in the hairline. It is still there but used to be rough and kinda bumpy feeling. Now it is smooth and is about 1/3 smaller than it was! I took pictures on the first day i started and will take more pictures at the end of one month and share them here. I am very surprised to see any changes at all this soon! Has anyone else experienced anything like this? I am loving life today!!!
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RECIPE PLEASE!!! I want to try this asap
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Could someone, off the top of their head, tell me how many mg of Rapamycin, I should mix into 3oz (88.7ml) of base lotion?
Thank You.
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Treatment described here:
Used 150mg Rapamycin in 150g of cream. Or, 0.1%.
please post this information if any one can explain the basic recipe
Quick update-
Oh who i am kidding? I talk way too much for this to be a QUICK update, but an update none the less.
First thing i wanted to share-When i first began I was crushing up my pills I used the butt of a screwdriver handle (I promise I washed it first, lol) as i didnt have a mortar and pestle. That was when I was getting all those weird papery pill covers in my cup. Apparently, a screwdriver handle doesnt make so good of a crusher. After i broke down and bought a little m&p on Amazon for less than 10.00 I got no more papery pill covers. So that problem solved 
Second thing was that I did notice some difference in the barnacle i had in my hairline after only a few weeks. It isnt gone, but has been reduced and is now smooth feeling, not bumpily. I think it is a touch darker in color but i will know for sure when i do my second set of pictures. As i was thinking on that I thought i would go back and re-read the article above that @Phillipe posted about the good results they were having treating childrens faces that had facial angiofibromas. I noticed this time in the article that they tried mixing rapa in both creams and gels. They had better success with the gels and surmised that the gel was ale to penetrate more deeply than the cream but still didnt get into the bloodstream. How did I miss that the first time? So i am going to order some Aquaphor and give that a try. I am only almost one month is in and plan to stay the course with this for at least 6 months so it will be awhile before i know for sure.
And the third thing, The Brexel test on the hands only used I believe 0.01% rapa for their test but for treatment of the kids with the facial angiofibroma they use 0.1% rapa, big (and more expensive) difference… Using @Steve_Combi 's math I tried to get as close to 0.1% as I could. But I only had 20 rapa pills left so I crushed them, soaked them in transcutol and then mixed them with only one ounce (28350 mg.) of lotion. That made a lotion with 0.07% rapa. One ounce isnt much but again I read in the article that they gave each patient one ounce of 0.1% rapa lotion and that lasted them 90 days! What!!! I have been slathering this stuff on my face, neck hands and lower arms so you can imagine how much I have been using, and I was trying to be judicious. 
And dont even get me started on my rapa toothpaste! (A post for another day, for sure!)
So my new plan is to apply the 0.1%rapa lotion on my barnacle and maybe half that strength on the rest of me. I want to give this test every opportunity to be successful because if this works and my barnacle completely disappears I might be taking a night job as i will be swimming in this stuff. J/K
Lastly i wanted to share all my numbers in hopes of saving others some time. i sat down and figured out how many rapa mg. and ounces of lotion I would need for different strengths of product. Here they are below-
2 oz. lotion or gel /.20 mg. rapa… .03%
2 oz. lotion or gel /.30 mg. rapa… .05%
2 oz. lotion or gel /40 mg. rapa… .07%
2 oz. lotion or gel /.50 mg. rapa… .08%
2 oz. lotion or gel /.60 mg. rapa… .1%
Luckily I have more rapa coming in very soon!
Have a great night everyone!
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I wonder how Rapa combined with hyaluronic acid and used with micro-needling would work? This should greatly enhance absorption. But maybe too much leading side effects?
Maybe I will make a batch of this and then try it out on a spot in my body. Has anyone tried this before?
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Can we use Propylene Glycol instead?
As I learned here, Mosley is selling a serum that contains 0.0125% rapa that I’m now using. Incase it’s helpful, I thought I’d share it requires refrigeration. I have no idea if that would help the diy version? Also, @Steve_Combi
It’s not a particularly elegant formulation (feels a touch grainy) which makes all of your diy experimentation intriguing. Once you all figure the perfect formula, I’m on board!!!
On the thought of @Alex, I wonder if there is a simple affordable product that exists that would be a good medium to mix it in… for instance, a serum from The Ordinary ? I ask this because I would not want my hair sticking to my Aquaphor face 
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A mortar and pestle is your friend
Also starting with a pure powder as opposed to a pill with excipients and a coating should make it much “smoother”
I’ve been putting this off for a while now and next week I’m going to make some 1.0% rapa lotion with the powder I have on hand.
As an FYI, I make my own base lotion from scratch and it only has 6 ingredients, this is from Humblebee and Me.
Heated Water Phase (temp to disolve)
Sodium Lactate (humectant)
Distilled water
Hyalauronic Acid - ULMW
Heated Oil Phase (temp to disolve)
Emulsifying wax NF
Argan Oil
Cool Down Phase
Germal Plus
For anyone interested in learning how to make skin care and other DIY products like that, I highly recommend this site;
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Found this on an internet search…
Excerpt: In an exemplary embodiment, a topical rapamycin composition is prepared by mixing 1 gm of rapamycin powder with 2 ml propylene glycol to make a paste. About 10 gm of a suitable carrier (such as Vanicream™) is added to the paste and mixed well.
Comment: Presumably this would be about a 10% concentration, which is WAY higher than what we are contemplating. Though somewhere in the document the author claims that concentrations as high as 5% do not seem to enter the blood stream in a meaningful way.
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That’s a bizarre patent. Using 2 off the shelf, commonly available and already commercial items to make a simple skin care product seems like it would not pass the “prior art” thing.
Talk about being lazy that they don’t even make their own base tells me a lot about the patent holder.
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For those in the know, is there any benefit to dissolving a rapa pill in vodka and then adding to a cream? I want to know if this would be enough for the rapa to be useful or topically absorbable.
Otherwise, if a serum/cream already has an ingredient like propylene glycol or dmso, or transcutol, would I need to buy more transition (etc) to make the rapa work topically?
If I must go buy a special ingredient, I will. But if there is an easier way with vodka, olive oil or any other household product, that would be much easier since I seem to be dragging my feet on this.