This was the only post of Ronald Evans when I searched the forum. He’s a wonderful lecturer.
Another quote from him from a video “Nuclear receptors and AMPK” (I’ll link a few vids) is:
“one of the holy grails in medicine is a pill that can offer the benefits of fitness, especially for those that can’t workout.”
People posting in this thread bring up concerning points on cancer related issues with some of the medications.
Hey, someone posted this video here this past week by Joseph Takahashi:
It was a very good discussion. I wanted to expand on this topic as it’s powerful stuff.
IIRC there are no products that directly target CLOCK or BMAL at this time.
However, has anyone tried those various products mentioned in the picture posted?
If so, how was your experience?
I’ve heard various products listed might help things like inflammation, energy, immune system etc.
Seems some of them are banned by wada under - metabolic modulators.
So they are considered very powerful products in performance(sporting) events.
Perhaps powerful for longevity as well.
I’ve heard a lot of good things about metformin, and other biguanides such as phenformin.
Ursolic acid has been talked about here in a more positive light.
Various flavones are well liked.
Heard good things about SR9009.
There could be some bad things also depending on various things as they are powerful molecules.
Listed:
KL001, KS15, Go compound
aicar, metformin
ckI-7, longdaysin, pf-670642, pf-48000567, compounds 1-3
sr1078, sr1001, nobiletin, neoruscogenin, digoxin, ursolic acid, sr3335
gsk4112, gsk2945, sr9009/9011, sr8278, arn5187
Resveratrol, SRT compounds
Well has anyone tried any of these?
I’ve tried metformin and resveratrol. Nobiletin is an interesting citrus nutrient.
I’ve done a deep dive on the research on both of these compounds using ChatGPT5 Deep Research:
SR9009 study summaries.pdf (49.8 KB)
Summarize SR9011 studies.pdf (34.5 KB)
GLP1 agonists activate PPARδ? So far only exenatide has data on this, I want to see more for semaglutide, tirzaepatide and retatrutide.
Short layman’s summary
This study looked at how GLP-1 drugs like exenatide protect pancreatic beta cells when they are stressed by too much fat. Beta cells are the cells that make insulin. When they are exposed to high levels of fat, especially palmitic acid, they start to struggle and their ability to release insulin gets worse.
The researchers found that GLP-1 drugs help the cells keep working properly by activating a molecule called PPAR delta. This molecule supports healthy mitochondria. Mitochondria are the parts of the cell that make energy. When the mitochondria are healthier, the beta cells can respond to sugar and release insulin normally.
They also found that a protein called UCP2 rises during fat stress and harms mitochondrial efficiency. GLP-1 drugs reduce UCP2 levels through their effect on PPAR delta. When UCP2 is reduced, the mitochondria work better.
Key observations:
Simple conclusion
GLP-1 drugs protect insulin producing cells from fat induced damage by turning on PPAR delta, which then lowers UCP2 and keeps the mitochondria healthy. Healthy mitochondria allow the cells to keep releasing insulin the way they should.
It appears that neither Tirz nor Reta turn on PPAR delta directly
GLP1-ra, specifically Tirzepatide and Retatrutide,.pdf (392.4 KB)
To be fair, the original paper itself did not claim direct activation of PPARd, just upregulation under certain conditions.
And that seems to be a possibility with Tirz and Reta as well.
Lack of evidence doesn’t mean it doesn’t happen, it’s just not something that has been looked into.
