Absolutely, NRF2 activation is a good thing: Does Nrf2 Play a Role of a Master Regulator of Mammalian Aging?
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And part of two things with the ITP now I think
- First Protandim, and a month ago the study with
- Astaxanthin
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I understand melatonin is an nrf2 activator.
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Did you stop taking that? What do you think about it? It is the one “medicine” that I’m considering adding to optimize my sleep
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At this time I only take it if I wake up in the middle of the night fully awake…not sleepy still. Lately I haven’t needed it for sleep. But maybe there is more to melatonin. I’m wondering about how to take it to get the longevity benefits without messing with my sleep.
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Got it. For me it would be the longevity benefits and also (a) can it extend my sleep from ~ 7-7.5 hrs of sleep to 8 hrs and (b) increase my deep sleep (from a sleep “quality” perspective at least according to wearables this seems to be my issue.
Any sense of how taking a slow release version of melantonin could help with (a) snd (b)?
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What you have to watch with melatonin is that depending upon when you take it in the sleep cycle (HPA cycle about 90 mins long) it can either help you sleep or wake you up. If it is going down (half life 30 mins) at the end of the cycle it will wake you up.
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So there is no way of doing an extended release just before going to bed?
(I don’t really wake up (in an aware state that I’m aware of) during the night so it would be difficult to take pills during the actual night)
Renue sells Liposomal melatonin (see below), which is effectively extended release, since any liposomal supplement will circulate in your blood for 4-8 hours. However at $29.95 for 90 capsules of 1mg, it may be hard to get enough for the life extension and anti-cancer benefits, so maybe combine Liposomal melatonin for deep sleep with 25+ mg regular melatonin just before bed ?
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I’ve been taking 500mg of the CocoaVia but it’s $1 per day on top of everything else I take. I am wondering if I really need it when I am also taking Rapamycin, Acarbose, Empagliflozin, Rosuvastatin, Ezetimibe, Taurine, Astaxanthin, Nattokinase, Telmisartan, and Nebivolol (among other things for heart health).
What are we thinking? Is it overkill?
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The answer is: How big is your budget?
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Thankfully it’s pretty big but I still don’t know if I want to spend $365 a year on this particular supplement if I won’t get much out of it since I take all those other things
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I use it but not everyday - for some effect, even if perhaps not full effect
If you have the money, I would rather invest in PCSK9i to further drive down apoB. But even with your current stack alone I don’t see how you could possibly develop ASCVD. Your focus should be on avoiding cancer, dementia, sarcopenia and infectious diseases.
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I think you’re right. My ApoB is 41 and my Lp(a) is good so I don’t want to spend a fortune on a PCSK9. I’m not going to reorder the CocoaVia when I run out. Also, I just read on examine that there are a surprisingly high amount of flavonols in dark chocolate
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Dark chocolate is also good for copper.
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overkill might be an understatement.
What are you looking for? 0? (jk) ApoB 41 is damn good! I think people here get pretty extreme when they’re saying uh, oh, my ApoB is 41…I really got to work on that.
And what do you think got it that low? I assume the rosuvastin and ezetimibe? I can’t imagine the CocoaVia doing much on top of everything else.
Uh, sorry, I forgot that I was in the nest of fanatics…Yes, definitely, add PCSK9i and don’t stop til your ApoB is 20. Why take a chance…
Keep beating that dead horse skeleton !
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It’s hard to offer advice when there’s so much we don’t know about you. Did you get a bad CAC? I don’t know your age. I found out heavy metals are a BIG deal, particularly lead. And it’s not that hard to treat.
Exactly, do you have any other problems that might be more worthwhile to work on?
Whazzat? Your pen just ran out of ink?
May i ask what is a preferred range for ApoB? Many of the papers i see have baseline numbers such as 1.35-1.49 so clearly im list in the units. My “estimated ApoB” was calculated to be 76. The guidelines I’ve seen is for ApoB below 130 (need statin), and better below 100, but i have no idea where this is in the overall range. You mention 41 is damn good. Is there a preferred range you are working from? Thanks.