Cardiovascular Health

The MRI is done with no contrast.

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Agreed, a bummer. And to think I should have a score of 3 by now and have zero - checked twice.

I have mentioned before on here that I have been on finasteride since I was about 32 years old (that is 33 to 34 years with no negative effects - all positive) - again like with rapamycin an early adopter. Finasteride is cheap and can be taken every day - or every 2-3 days.

Thanks to finasteride – I still have my hair. My urologist goes on an annual hunt to locate my prostate - the size of a person in their mid-20’s. He thinks it is funny to tell me - I know it is in here - somewhere. Another great benefit is your prostate doesn’t grow or act up.

Recently a possible 3rd benefit. NIH Report Link: Commonly prescribed hair loss drug might lower risk of heart disease | NHLBI, NIH.
Analyzing data from the National Health and Nutrition Examination Survey between 2009 and 2016, researchers found a significant link between men who had taken finasteride and lower cholesterol levels – on average, 30 points less than men who were not on the medication.

In a follow up study, the researchers dosed finasteride to mice that were genetically predisposed to develop atherosclerosis along with a high-fat, high-cholesterol Western diet. They found that the highest dose led to reduced cholesterol, delayed development of atherosclerosis, and reduced liver inflammation.

According to the study authors, “our data unveil finasteride as a potential treatment to delay cardiovascular disease in people by improving the plasma lipid profile.”

Cheap medication - you might consider for cholesterol. There are those that say it can dampen their libido (but reports say that is bunk). Concerned … go ahead and do tadalafil with it. My urologist says its great for urinary health.

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I just had 2 MRI scans on the same day, for chest and abdomen. They explained that if it’s done without contrast iit is insensitive to malignancies if they exist. To cover potential malignancies it has to be with contrast. The contrast they use is called Vieway.

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It depends on a number of factors - including resolution of the machine and the familiarity of the Radiologists with reading high volume of such scans for this purpose. So we have 2 major groups Prenuvo and SimonMed doing these scans for this reason. Neither of them feel the need to use contrast.
I’m happy leaving it to the experts - as panels of Radiologists determined what they feel is sensible.

You can see Prenuvo’s answer to this issue under their FAQs … They feel pretty good about not using contrast and feel it has sensitivity and specificity for detecting tumors as part of general population screening.

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This is what was in the findings they sent to me after the MRI scans: The lack of IV contrast renders this examination insensitive for evaluating for malignancy. So I want to understand why my scans required contrast for the complete picture and yours did not. Does it depend on the equipment used?

So Radiologists love to basically shield themselves from making any definitive statement. It is classic on all our abdominal CT’s we do without contrast - they’ll say it decreases their likelihood of finding inflammatory or infectious issues (which it does a tiny bit). However, there are some radiologist very happy reading for those things without contrast.
The MRI done in a standard facility with standard techniques is probably not exactly geared to do what these ones are, where they know in advance, all scans non-contrast, everything optimized for screening for things, including cancer. Radiologists who are focused on this, and doing high volume of scans on this same machine, same protocol and same reason.
I’d guess it is a combination of all those factors that has groups like Prenuvo and SimoneMed comfortable with their approach. No test is 100%.
I’m just looking at this as screening, and happy with the limitations.

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The co-founder of Prenuvo explains their technology in this Peter Attia episode: #61 - Rajpaul Attariwala, M.D., Ph.D.: Cancer screening with full-body MRI scans and a seminar on the field of radiology - Peter Attia

In a nutshell, he says it’s a custom MRI machine using custom processing software.

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