Of course it is, but it’s going to take time and people aren’t prepared to wait. We’re a good example of that aren’t we? We’re all tinkering around the edges to see what we can do to slow things down. I still think at the core Bryan’s idea is sound, it’s just technology needs to catch up with him.
Interesting to see latanoprost being used. Years ago, when latisse entered the scene, I expected to see it take over and nudge minoxidil out of the spotlight. Because it never happened, I assumed the studies never panned out .
I use minoxidil aprox 3x per week just as a preventative, and even at that dose, it does minimize shedding.
Do we know how latanooprost stacks up?
If you have nothing to hide, you have nothing to fear.
Tfw you at blueprint after a signing “non-standard” confidentiality agreement
Bryan has as far as I remember always said the biological age tests aren’t accurate, that’s why he uses pace of aging.
Some examples off the top of my head that’s new or haven’t tested
- Measuring sodium storage in the body with e.g sodium MRI, correlated with diseases
- ATTR accumulation
- Drugs for above
- Testing new ITP drugs, replacing with other ones, e.g Estriol instead of 17-A-E, or trying SGLT2i
- Maybe Higher CR with GLP-1 agonist to prevent hunger (will look like elf or skeleton), (more dangerous?)
- Decreasing apoB further
- Mental tech, relating to meditation, maybe much better mental space, e.g jhana at https://www.jhourney.io/
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- Mechanism:
Latanoprost, a prostaglandin F2α analogue, is known to stimulate melanogenesis, the process of producing pigment, which is why it can cause increased pigmentation of the iris and eyelashes. In some cases, this stimulation extends to hair follicles, leading to repigmentation of gray hair.
Latanoprost is a prostaglandin analog that works by stimulating hair follicles. It prolongs the anagen (growth) phase of the hair cycle, leading to increased hair density and thickness.
Efficacy:
Studies have shown that topical latanoprost can promote hair growth in individuals with androgenetic alopecia (male-pattern baldness). In one study, 0.005% latanoprost solution significantly increased hair density and reduced hair loss compared to placebo.
Dosage and Administration:
Latanoprost is typically applied as an eye drop once daily. However, some studies have used higher concentrations or more frequent application for hair growth purposes. It is important to consult with a healthcare professional before using latanoprost for hair growth.
Side Effects:
The most common side effects of latanoprost eye drops include redness, irritation, and increased eyelash growth. In rare cases, it can also cause allergic reactions.
Conclusion:
Latanoprost has shown promise as a potential treatment for hair loss. It works by stimulating hair follicles and prolonging the growth phase. However, further research is needed to establish its long-term efficacy and safety for hair growth. It is essential to consult with a healthcare professional before considering using latanoprost for this purpose.
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I do wish Bryan was more transparent about his pace of aging tests. The average of his 3 best scores looks quite impressive, but I’d be curious what the full distribution looks like.
Anecdotally, my pace of aging worsened despite many biomarkers improving, which is a bit perplexing to me. The TruDiagnostic test is quite opaque, but some of the methylation correlates they reveal were not even close to my measured markers, which makes me a bit skeptical of my results overall.
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The problem is, the guy is putting out this really nice aim of n = 1 experimentation and sharing data. However, he doesn’t actually share all the data, and he isn’t truthful with the recent updates. Instead, he puts out things which are incredibly misleading, and seem to be cherry picked. For example, compiling the best individual results and putting them out together as if that’s his status quo situation.
I don’t think he will flame out exactly, because he is still gaining popularity in the “normie” crowd who have no idea that “anti-aging” is even a thing. But he won’t be credible within our field any more IMO.
The other major problem, IMO, is that the dude is worth 9 figures but refuses to actually fund, or participate, in any proper science. Sure, it’s his money, but for a few million, he could work with the best scientists in the field, sponsor research and get real results very quickly. If he is genuinely interested in never dying, that’s the most likely thing to yield success.
Lastly, the NYTimes story is a nothingburger IMO. It’s pretty standard “rich dude” protocol. And he does make a point that he’s literally measuring night time erections, testing his sperm, going around naked etc. Anybody joining the team should know what they’re getting themselves into.
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If he really wants to help people to Not Die, then he should fund research. An ITP trial would be the very minimum IMHO.
It could also lead to better business if he discovered something that worked. He needs to take one for the team otherwise he’s just a selfish marketeer riding on longevity coattails.
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Bryan’s moat in the longevity space isn’t money, it’s that he is at the forefront of the current longevity zeitgeist, him funding an ITP trial would have near zero effect from his own contribution. It only makes sense from a propaganda perspective IMO and get others who are aligned, interested at some point, but feels kind of early.
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Pace of Aging standing in the rejuvenation olympics is based on last 3 tests within 2 year period. So unless he is paying off Trudiagnostic he is not manipulating this stat
Rankings are determined by the average of the three lowest pace scores achieved by participants within the last two years. This method rewards consistent performance and improvement.
Confirm for yourself here: Rules
What confuses me is that I see Bryan Johnson testing many protocols at the same time, and we all know that what may work for one person may not work for another. So, how can he filter the Blueprint information for daily practice given so many different nuances and complexities among humans? We all know that the basic protocol (sleep, stress, diet and physical activity) helps a lot in general, and he is 100% dedicated to this. However, what is the significance of each supplement and other interventions on top of the basic protocol? In 10-30 years or as long as he sticks to his protocol (that keeps changing), we will know HIS results. But again, the results will come from his body and nothing tells me that the same will work for x, y or z… or thousands of people to maintain good health… and I’m not even thinking on his “don’t die” motto. In conclusion, he is testing a protocol that may fit “his” organism and ideology. Good luck to him and to all others doing something similar but the strong marketing, draconian contracts and so on turns me completely off.
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Part of the article that links to:
Bryan’s call to “Don’t Die” now rings in my ears as “Don’t Lie” every time I hear it. I hope the societal mechanisms for truth will be able to help him make a course correction. I hope he will release the BP5000 data set and apologize to participants. But Bryan Johnson feels to me like an unstoppable marketing force at this point — full A-list influencer status — and sort of untouchable, with no use for those of us interested in the science and data.
To be fair to Bryan I have started the process of setting up “Hemming Biohacking” which will enable me to sell specialised biohacking interventions on Amazon (inter alia). I have found it difficult for people to make up my suggested interventions and so am getting some concentrated gene food made up (mixed citrates). Hence I will be in the supplement selling business and subject to the same conflicts of interest.
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+Candesartan 8 mg daily
+Jardiance 10 mg daily
+Repatha 140 mg Q2W
https://x.com/bryan_johnson/status/1912215163509588305#m
New biomarkers and lab results
https://x.com/bryan_johnson/status/1912215143846723703
More results on X:
Lab Results, pages 1-4: https://x.com/bryan_johnson/status/1912215147818655959
Lab Results, pages 5-8: https://x.com/bryan_johnson/status/1912215150784049207
Lab Results, pages 9-12: https://x.com/bryan_johnson/status/1912215153724236116
Lab Results, pages 13-14: https://x.com/bryan_johnson/status/1912215156681232627
What are people’s thoughts?
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For once good interventions!
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Cross-posting this here for those who are interested in Joseph Everett (What I’ve Learned) videos on BJ. It’s (my) commentary carefully watching, noting the inconsistencies in WIL’s messaging. Any influencer that takes that shit seriously enough to recommend it, discredits themselves IMO as either being inattentive, biased, etc.
I dunno man. ITP runs on a pretty small budget. Bryan could easily help the ITP to 10X their capacity, and it could vastly improve our understanding of longevity interventions. I don’t think that would be near zero effect.
Like, he chases down these “fancy” interventions like HBOT, laser shockwave etc, but the bigger bang-for-buck is going to come from things like molecules, gene therapies etc. Guy flew to some Caribbean island to have gene therapy. If “Don’t Die” is really a truthful mission statement, wouldn’t it make sense to fund some good trials?
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I may have helped me understand my SHBG being high - does below sound right to people
From Brian:
Is this true:
SHBG - is slightly elevated due to high levels of exercise, optimal insulin, low body fat and high metabolic demand. It’s common in high-performance athletes.
(Does seems that 3o ChatGPT concurs)
What do you think about this from
Bryan:
Vitamin B12 level is 1815 pg/mL, high (ref range 200–900 pg/mL). B12 is essential for energy production, brain function, and DNA synthesis. We have targeted a higher B12 level to optimize methylation. High levels are usually harmless. Could also be from enhanced absorption from HBOT. No action being taken.
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