Bryan Johnson, Is he the New Poster Child for Rapamycin Use?

My predictions for 2500 are either

  1. everyone gets to live in their luxurious computer simulations directly attached to their brains
  2. AI goes out of control and converts this star system and the nearest stars into giant processors to better compute some graph algorithm
  3. everyone gets dumber and more reliant on technology whille technology itself keeps advancing but ever more slowly → basically Idiocracy
  4. we finally have enough and nuke each other to death and what remains of humanity continues to live with 19XX tech
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  1. everyone gets to live in their luxurious computer simulations directly attached to their brains.

Ummm… the Matrix… after seeing AI relationship programs… you might be right.

Weird! What is real?

Replika site

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Not as fulfilling as a real relationship I suspect (but perhaps better than some relationships :wink:

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Bryan Johnson Says He Doesn’t Want to Run Blueprint

Gee… big surprise! Messed up dude!

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Why does he have to “run” it?

Can’t he afford to bring in a competent management team or partner to do that?

His rational is that he wants to spend more time on his new religion and the business is “tainting” his message and harming his credibility. So a complete divorce is what he see’s as freeing him to be the savior of the world. As he saw in a dream…

Basically another marketing move.

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Bryan Johnson cult.
Hahaha. Something for everyone.

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I am not sure it is a marketing move other than him wanting to sell his olive oil business if anyone wants to buy it.

His problem is that he doesn’t really have any scientific advantage.

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He is concerned about how his “message” for his new religion is getting tainted by selling (supplements) based on what he is preaching. Clearly stated in his interview.

He wants himself as the leader of his new religion to be taken “seriously” as he leads the flock to his next great thing. Said indirectly in his interview.

That is 100% a marketing move. Religion is a business.

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He can make money out of religion without having to ensure that the olive oil is any good.

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His detailed comment: (which seems at the end to be a U turn)

https://www.twitter.com/bryan_johnson/status/1947856316875346250

"Blueprint has been a pain in my ass.

It’s kept me from not focusing on the single thing I’m consumed with: how does the human race survive the rise of super intelligence.

Every minute spent dealing with problems like ‘why a supplier shipped us something out-of-spec’ (now stuck on a boat) is a minute not spent figuring out how to make Don’t Die the fastest-growing ideology in history, increasing our odds of survival and thriving.

At the same time, Blueprint products bring my body and mind great joy. I rely upon them for my well-being. I trust it. So do tens of thousands of happy customers. After years of consuming, I am - at a molecular level - Blueprint.

Blueprint is the best longevity stack in the world. That’s not an exaggeration. It’s meticulously designed. Based upon scientific evidence. Third-party tested. Comprehensive, easy to consume, delicious and priced to be accessible.

There’s nothing else in the world like it.

Initially, I tried combining existing ingredients from third-parties to match what the scientific evidence recommended. That didn’t work. The ingredients were off. They didn’t have third party testing. I had to manage 100+ vendors. There were too many pills. They had varied or non-existent quality controls.

I built Blueprint to solve my own problem. My goal was to achieve the best biomarkers of anyone on planet earth. Nutrition was going to play a very important role.

I was trying to demonstrate - IRL - what Don’t Die means minute to minute and day to day. To practically demonstrate and be the philosophy.

Four years in, my team and I have accomplished that goal. I have the best biomarkers of anyone in the world. I am the healthiest person on earth. I’ve publicly shared my markers and lab work for review.

Throughout this process, I’ve shared everything I’ve learned, with everyone, for free.

Blueprint has played a major role in this. Each day, I consume around one septillion (10²⁴) nutrient molecules, tiny packets of chemical energy that determine how my body runs. Each molecule has fought for its life for inclusion.

After my team and I built a protocol for myself, my friends and family asked if they could get access too. Then their friends and family asked and I said yes again. The circle kept on expanding until we stumbled into Blueprint becoming a company.

My goal was never to sell nutrition. It’s the last thing in the world I ever imagined doing.

I don’t need the money.

I would much rather be building in deep tech: the engineering of life and intelligence using biology, physics, materials, software, and computation.

After I sold Braintree Venmo for $800M, I invested in synthetic biology, precision chemistry, genomics, and computational therapeutics, aiming to make biology programmable like software. I believed these fields could enable breakthroughs like a global immune system, life-extending medicines, and cleaner, better materials.

I then founded and funded Kernel, building the world’s first mass-market, non-invasive brain interface. It’s a bike helmet fMRI, to pair the human brain with AI and accelerate our evolution. It took 9 years and pushing the boundaries of physics, but we succeeded. Kernel Flow is now in clinical trials for mild cognitive impairment and depression. I keep a Flow on my desk and measure my brain daily to track my health protocols.

I started Blueprint and people began calling me a grifter. Whatever. They don’t understand.

Then Blueprint and Don’t Die became a global thing. Netflix did a documentary. The grifter blowback got increasingly loud. Somehow making my protocol available at a low cost lessened the trust that some people had in me.

Call me Patrick Bateman, Dorian Grey, Prometheus, a vampire, or elf, I’ll laugh with you. The questioning of my intentions hurts the mission.

My sole purpose in existence is the survival and thriving of the human race.

So earlier this year when WIRED’s Katie Drummond asked me about the tension of Blueprint and being called a grifter - I was like fuck it. Should I shut the company down or sell it? I’d been thinking about how to solve this tension. That sucks because we have tens of thousands of happy customers who also depend upon Blueprint. But it takes me away from Don’t Die. It hurts my credibility.

While this question may seem unique to my situation, it’s really what so many are now grappling with.

With AI advancing so rapidly, what do any of us do right now? What’s worth doing anymore? Everyone in my circle is asking this same question, but in their own way.

The truth is that I need Blueprint.

The world needs Blueprint.

It is the practical manifestation of Don’t Die.

The interview referenced was 3 months ago.

Since then, I’ve explored the options.

We’re going all in. We’re making Blueprint accessible and impactful for everyone. To replicate everything in my protocol - all the measurements, protocols, therapies - and make it easy and accessible for others to do in community. For your family and friends to do this too.

We are marrying Blueprint (daily practical health) and Don’t Die (philosophy and global action), as they really are the same thing.

  • Blueprint Nourish: Premium fuel for your body, covering 50-100% of your daily nutrition, hair care, skin care, oral care, etc.

  • Blueprint Biomarkers: Health as an AI-first, fun, social, and competitive experience. Leaderboards and rewards. Your progress tracked each day.

  • Blueprint Quantified: A global certification standard for food purity. First for pets, then humans. To help everyone know exactly what’s in their food and raise the global standard.

  • Blueprint Clinics: Heal damage inflicted by the world. Get access to cutting edge longevity technologies, protocols, and therapies. Locations around the world. Blueprint centers and licensees.

To do this, we’re raising money and we need hard core builders.

I’m hiring a CEO and CTO who can lead the business day to day while I focus on Don’t Die.

… Red Bull made adventure a universe.
… Duolingo made language-learning fun.
… Blueprint will make longevity a game.

A new era is here.
Death is our only foe.
We are the first generation who won’t die.

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I want to like the guy but what thing here is something new? What does it get him other than more money? You can’t take money with you when you die, he needs to invest in new treatments.

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Exactly!

It is hard to trust or like this dude. Wacko.

His all knowing N=1 arrogence took a major dump on rapamycin, the only current molecule known that might help in health span and life span. In my opinion, he did a lot of damage to the momentum that rapamycin was finally getting in the media. Even Matt Kaeberlein felt obligated to call him out on it in a podcast.

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I am not going to defend the guy. Clearly he has issues - calling himself the healthiest person on earth makes one wonder about his judgment along nany axis, not to mention psychological profile and knowledge base.

That said, some things he said about Blueprint resonated. I too have thought about my own needs and standards and how what’s available commercially is a travesty. I therefore did think about making my own supplements from properly sourced ingredients, in the forms and dosages I think are optimal. And given the huge effort that would involve, inevitably it would make sense to make that available to others, because you can’t accomplish many of these goals without the scale only a wholesale approach allows, so starting a supplement company is the obvious route. But that would immediately cause some to see this as a money making business, and cause people to accuse me of being money motivated, even though my sole motivation was to get optimal supplements for myself. So I completely understand his attitude of “fuck it”, because that certainly was in my mind. Ultimately I didn’t feel I had the time or money to sink into such a venture and my energy is spent better elsewhere. This is hardly a unique thought process. Many others have gone down that path. Brad Stanfield of yt fame also generated a supplement because he couldn’t find what he needed for himself. But we all have our own standards and knowledge base we go off of, so one can’t just rely on someone else (see Blueprint cacao and heavy metal scandal).

Bottom line, just because the guy is a head case doesn’t mean he’s not right about some things.

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I didn’t buy Blueprint before and won’t do it now or in the future after such statement by its creator.

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MicroVitamin is slowly converging towards the kind of multivitamin I want so at least there is that. V8 has lutein, zeaxanthin and astaxanthin in it.

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Yeah, that’s why we all have our own ideas and can’t simply rely on others. Blueprint supps throw things together I don’t want. Microvitamins same thing - I don’t want a lot of stuff in there. I don’t want astaxanthin in the same pill as lutein and zeaxanthin as they interefere with each other (lutein zeaxanthin and meso-zeaxnthin work well together). And so on. I favor single ingredient supps exactly for that reason - I time them and don’t want to take them together. Or the dosages or forms are wrong. And so on endlessly. How does micorvitamin source their ingredients - it seems all to rely on some subcontractors, who knows about the quality. It’s endless. Which is why we all have our own ideas and needs. I loved it when back in the day you could put together a protein mix from individual aminoacids by % - so I could keep mentionine and isoleucine low etc. That option is gone. In many ways we’ve moved backwards in the supplement space as we rely more and more on ingredients sourced from China and costs are all that matters.

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I trust Dr. Stanfield and his micro vitamin 100X more than Bryan Johnson. At least he ponies up the money to do a Rapamycin trial. What has Bryan done to advance longevity??? And Dr. Stanfield is just a regular Joe, not a 500 million dollar tech bro.

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Humble doctor working like 120 hours a week as a practitioner + youtuber + researcher + vitamin salesman + family father of 3 who looks pretty good with a stack that costs about $100 per month vs rich prick who doesn’t even look particularly good for his age despite allegedly spending two million dollars per year on his health.

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According to his discord the newest version of microvitamin won’t have astaxanthin due to insufficient evidence of benefit

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His most recent newsletter… :man_facepalming:

It’s true. Blueprint has been a pain in my ass.

It’s kept me from not focusing on the single thing I’m consumed with: how does the human race survive the rise of super intelligence.

Every minute spent dealing with problems like ‘why a supplier shipped us something out-of-spec’ (now stuck on a boat) is a minute not spent figuring out how to make Don’t Die the fastest-growing ideology in history, increasing our odds of survival and thriving.

At the same time, Blueprint products bring my body and mind great joy. I rely upon them for my well-being. I trust it. So do tens of thousands of happy customers. After years of consuming, I am - at a molecular level - Blueprint.

Blueprint is the best longevity stack in the world. That’s not an exaggeration. It’s meticulously designed. Based upon scientific evidence. Third-party tested. Comprehensive, easy to consume, delicious and priced to be accessible.

There’s nothing else in the world like it.

Initially, I tried combining existing ingredients from third-parties to match what the scientific evidence recommended. That didn’t work. The ingredients were off. They didn’t have third party testing. I had to manage 100+ vendors. There were too many pills. They had varied or non-existent quality controls.

I built Blueprint to solve my own problem. My goal was to achieve the best biomarkers of anyone on planet earth. Nutrition was going to play a very important role.

I was trying to demonstrate - IRL - what Don’t Die means minute to minute and day to day. To practically demonstrate and be the philosophy.

Four years in, my team and I have accomplished that goal. I have the best biomarkers of anyone in the world. I am the healthiest person on earth. I’ve publicly shared my markers and lab work for review.

Throughout this process, I’ve shared everything I’ve learned, with everyone, for free.

Blueprint has played a major role in this. Each day, I consume around one septillion (10²⁴) nutrient molecules, tiny packets of chemical energy that determine how my body runs. Each molecule has fought for its life for inclusion.

After my team and I built a protocol for myself, my friends and family asked if they could get access too. Then their friends and family asked and I said yes again. The circle kept on expanding until we stumbled into Blueprint becoming a company.

My goal was never to sell nutrition. It’s the last thing in the world I ever imagined doing.

I don’t need the money.

I would much rather be building in deep tech: the engineering of life and intelligence using biology, physics, materials, software, and computation.

After I sold Braintree Venmo for $800M, I invested in synthetic biology, precision chemistry, genomics, and computational therapeutics, aiming to make biology programmable like software. I believed these fields could enable breakthroughs like a global immune system, life-extending medicines, and cleaner, better materials.

I then founded and funded Kernel, building the world’s first mass-market, non-invasive brain interface. It’s a bike helmet fMRI, to pair the human brain with AI and accelerate our evolution. It took 9 years and pushing the boundaries of physics, but we succeeded. Kernel Flow is now in clinical trials for mild cognitive impairment and depression. I keep a Flow on my desk and measure my brain daily to track my health protocols.

I started Blueprint and people began calling me a grifter. Whatever. They don’t understand.

Then Blueprint and Don’t Die became a global thing. Netflix did a documentary. The grifter blowback got increasingly loud. Somehow making my protocol available at a low cost lessened the trust that some people had in me.

Call me Patrick Bateman, Dorian Grey, Prometheus, a vampire, or elf, I’ll laugh with you. The questioning of my intentions hurts the mission.

My sole purpose in existence is the survival and thriving of the human race.

So earlier this year when WIRED’s Katie Drummond asked me about the tension of Blueprint and being called a grifter - I was like fuck it. Should I shut the company down or sell it? I’d been thinking about how to solve this tension. That sucks because we have tens of thousands of happy customers who also depend upon Blueprint. But it takes me away from Don’t Die. It hurts my credibility.

While this question may seem unique to my situation, it’s really what so many are now grappling with.

With AI advancing so rapidly, what do any of us do right now? What’s worth doing anymore? Everyone in my circle is asking this same question, but in their own way.

The truth is that I need Blueprint.

The world needs Blueprint.

It is the practical manifestation of Don’t Die.

The interview referenced was 3 months ago.

Since then, I’ve explored the options.

We’re going all in. We’re making Blueprint accessible and impactful for everyone. To replicate everything in my protocol - all the measurements, protocols, therapies - and make it easy and accessible for others to do in community. For your family and friends to do this too.

We are marrying Blueprint (daily practical health) and Don’t Die (philosophy and global action), as they really are the same thing.

  • Blueprint Nourish: Premium fuel for your body, covering 50-100% of your daily nutrition, hair care, skin care, oral care, etc.

  • Blueprint Biomarkers: Health as an AI-first, fun, social, and competitive experience. Leaderboards and rewards. Your progress tracked each day.

  • Blueprint Quantified: A global certification standard for food purity. First for pets, then humans. To help everyone know exactly what’s in their food and raise the global standard.

  • Blueprint Clinics: Heal damage inflicted by the world. Get access to cutting edge longevity technologies, protocols, and therapies. Locations around the world. Blueprint centers and licensees.

To do this, we’re raising money and we need hard core builders.

I’m hiring a CEO and CTO who can lead the business day to day while I focus on Don’t Die.

… Red Bull made adventure a universe.

… Duolingo made language-learning fun.

… Blueprint will make longevity a game.

Yesterday, we received this message:

For those of you that support, buy, and rely on Blueprint, thank you.

I feel you, I love Blueprint products too. I know how hard it is to get access to high quality nutrients.

A new era is here.

Death is our only foe.

We are the first generation who won’t die.

Bryan

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