Bryan Johnson, Is he the New Poster Child for Rapamycin Use?

@AnUser Bryan has a message for you.

3 Likes

Noo Bryan! Not Ronald McDonald! :sweat_smile:

I’m lucky I’m weaning off it with blueprint type foods.

3 Likes

McDonald’s has this sweet deal… $5 you get a medium fries, 4 chicken nuggets, a McDouble burger and medium drink. My current go to lunch past 2 weeks.

Why? Rapamycin seems to let me eat anything and everything… no weight gain or is dues with blood markers. But yeah, Micky D’s in moderation. Hahaha.

1 Like

That price is insane!!!

This is further proof that genes are everything. I’d be dead by nightfall :slight_smile:

3 Likes

Hahaha… there is genetics and phenotype.
Won’t argue with that…

1 Like

And in today’s news, he posted slides describing his discontinuation of rapa

Link to the post
https://www.instagram.com/p/DDuqFV4zbog/?img_index=5&igsh=MzRlODBiNWFlZA==

I won’t post all of them, but this screen shot of one slide is not fun to see!!

2 Likes

That was a useless study… see the discussion here: The Effect of longevity interventions on epigenetic clocks (BioRxiv)

and his entire decision was evaluated here: Bryan Johnson stops rapamycin

6 Likes

That mostly was indeed.
Trudiagnostics has a well informed video presentation on that study.

For instance:

BTW The presentation slides are here.

2 Likes

I guess his kid’s blood isn’t good enough either… cast off like his rapamycin dosing. I am sure his kid - Talmadge (the name means pouch - wallet, begger’s bag), is pleased to be out of his dad’s youth intervention.

Immortality-Obsessed Tech Guy Trying New Technique That Involves Removing “All Blood From Body”

2 Likes

Given my experience with Plasma Exchange (6 treatments over 3 months, with minimal or non-noticeable improvements) I think he’s wasting his time and money with this new focus on TPE. He’s in good shape, I doubt he will see any benefit. Sometimes I suspect he does things just because they are unusual, expensive and generate good amount press or attention (even if they don’t provide any value).

3 Likes

His team of doctors are probably all yes men optimizing for appeasing Bryan and making the money spent consulting him or whatever worthwhile for him. People are chimps, unless there is a rock solid system in place to prevent this, it will happen. That might be why he put a bunch of weird elixirs in his hair serum that he later removed after one YouTuber commented on it, seemingly.

4 Likes

“… looking as uncannily youthful as ever.” Quote from the article - really?!? Hahaha!

I am with the anorexic assessment.

2 Likes

Doesn’t look a day over 15.

3 Likes

His post on X notes that the anti aging effects were not seen at the end of the study, only the middle, confirming my assessment here.

It’s curious that despite this, he still proceeds with TPE + IVIG. Some thoughts:

  1. I would guess that he will see a reduction in microplastics from the TPE. Hopefully he plans to test this.
  2. Any other benefit is likely due to the IVIG infusion, and will depend on whether or not his immune markers are in a place that would be moved by this intervention. Since he hasn’t publicly disclosed these, hard to say what he expects to have happen.
  3. There are other low hanging fruit with much better evidence for anti-aging or disease prevention like SGLT2-inhibitors. Of course, if he tried an SGLT2-inhibitor he would almost certainly stop it after seeing the transient decrease in eGFR (like he did with GLP-1s and the likely transient increase in RHR). I can’t help but think that he’s doing this because it’s relatively inaccessible and flashy. A photo of a bag of plasma along with a description of the cost of treatment does a lot more for his brand than taking a prescription medication.
3 Likes

I think he’s becoming a media hound instead of actually trying to live longer nowadays. Whatever keeps him in the headlines…

5 Likes

And now this on NPR. I think Matt Kaeberlein was too kind to Bryan… lol

Bryan’s reasons for stopping rapamycin after 5 years… infections and heart rate… could have been too much rapamycin too often. It’s the dose - dummy.

Link: Tech entrepreneur Bryan Johnson discusses his quest to slow aging : NPR

MATT KAEBERLEIN: I think there’s value in these individual N-of-1 experiments where people are testing different things on themselves, but it’s never going to be accepted by the broader medical community or regulatory agencies. We need the more rigorous clinical trials.

MARTÍNEZ: And Johnson himself has admitted that some things he’s tried have not worked. Take rapamycin, for example. The drug has been shown to slow down the aging process in mice, but it is unproven in humans. Johnson took it for five years before stopping. He posted on X that he decided to stop taking the drug because of side effects such as infections and an increased heart rate.

4 Likes

Sadly if Bryan really did dose rapamycin for 5 years… he probably already gained a huge life extension benefit. But, will credit everything but rapamycin.

Not wanting to be conspiratorial… but Bryan could be paid off… in more ways than cash… by big pharma to poo-poo rapamycin. It’s benefits can hurt the bottom line in profits.

As Matt Kaeberlein said in one of his podcast… do you trust him… do you know his motivation?
He is obviously self promoting to the point of satire… and mockery. No such thing as bad press. Lol.

1 Like

I don’t think you need to consider conspiracies… Just him taking rapamycin and doing “well” can easily be ascribed to rapamycin and not all the things he’s selling and taking, so I can see an incentive for him to dump rapamycin.

But ultimately it doesn’t matter. Everyone should make the best decisions for him or herself based on good data.

6 Likes

Exactly.

Works for me… I am definitely getting benefits well past my shelf-life.

Going for top shelf instead. Hahaha!

4 Likes

Hmmm… wasnt he charging twice as much for an expensive body scan?

Bryan talks about over priced supplements. Maybe take the basics D… K2 , Omega 3,
Taurine, Creatine, B12… melatonin and rapamycin…and call it good. :wink:

4 Likes