I missed that. Very interesting, and very easy and cheap to do if the import/export channels are open… but if not 
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Thank you. Yes, that’s a very interesting hypothesis. I don’t know that anyone has proven this out, or if anyone has tried it with positive results? Matt K. also suggests a rapa toothpaste for periodontal and other general oral benefits.
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LOL, exactly. He’s just polishing himself for a larger commercial foot print. Near zero new info (IMHO) just polish and promo.
Read his book, tossed it. Too drug-y (statins) too decade old… Nothing new (for me). Today this article; Just buz and promo IMHO nothing new for us. Sure lots new for SAD’ers, sick Americans but thats not us here.
Good luck, curt
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A quote from his recent longevity 101 podcast really struck me how big the shift has been from “life extension” to “let’s just try to slow the damage a little”
“I was thinking about this today in the gym actually, I was like, wow, it is really so obvious to me with each passing day that I am completely past my prime physically and cognitively. And I will never again be as physically strong, fit, flexible, free of pain.
Like pick your metrics that all make up physical health span. I will never again reach the pinnacles that I had reached in my late teens and 20s. And similarly, cognitively, I’m basically a moron compared to the person I used to be, in terms of processing speed, problem solving, just raw intellectual horsepower.
Those things are going to decline even further.”
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Oddly, in my 85th year, I am more pain-free than I was in my 20s and 30s. In my late 20s, I was being treated regularly for pack pain, and I remember often having headaches. In many areas, I am still as physically strong in terms of raw muscle power because I have been going to the gym, running, and playing tennis most of my life. What I have lost is speed, endurance, and reaction time.
I don’t even remember the last time I had a cold or the flu, at least many decades ago.
What do I attribute this to?
Exercise
Poly pharmacy
Rapamycin (Shortly after starting rapamycin in Dec. 2021, at a relatively high weekly dose, I have been pain-free, including headaches and the typical pain that accompanies old age, arthritis, neuropathic pain, and fibromyalgia.)
Genes
Immunization shots. (Because of the military and my employment in foreign countries, I have received too many shots to remember. Starting from childhood to my most recent flu shot. Among them are mumps, measles, tetanus, diphtheria, pertussis, and yellow fever, etc. My most recent vaccines in the last few years are influenza, COVID-19, shingles, RSV, and pneumococcal. The only one that I had a severe reaction to was the Pfizer COVID-19 vaccine.)
Cognitively, the most significant decline has been in processing speed, the ability to do math problems in my head, and the ability to memorize lists, etc., for any substantial amount of time.
Subjectively, my most significant decline is in energy and endurance, though I still seem okay at the gym.
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My story’s a little different, but has in common with @desertshores that my experience of general health and lack of pain is notably better now in my 60s than it was in my 20s.
It’s not a simple equation – some things are better, some are not. For me, it’s likely that I was particularly impaired in early adulthood, with deleterious biochemical inputs (pollution, etc) that cost me health. But also, in those days, estrogen wasn’t bioavailable as it is now, and that had a strong effect on me, too, positive and negative.
Yes, my energy was better then as was my ability to put on muscle mass. (Then there’s elastin which I sure miss having plenty of.) But I was injured a lot, sick a lot, and didn’t have mood stabilization. Significantly better now.
Among the many things to which I attribute my impressive health improvements are 15 years of methylation cycle supplementation (like a reboot), ceasing non-bioidentical estrogen in my 20s, recent bioavail HRT, and two years of rapamycin.
There might be other factors. I eat well, exercise regularly, and prioritize human contact. There are a lot of inputs.
My point: yes, it is possible to feel better in many ways than you did in your twenties, depending on how things were for you in your twenties. I’ve been working this stuff for 40 years, because I had to. My health – and at some points my life – depended on my figuring things out. I’m still figuring things out.
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